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| Ensembl ID | ENSG00000196396 | Gene ID | 5770 | Accession | 9642 |
| Gene Symbol | PTPN1 | Alias | PTP1B | Full Name | protein tyrosine phosphatase non-receptor type 1 |
| Position | 20 : 50510321 - 50585241 | Length | 74921 bases | Strand | Plus strand |
| Status | Confidence | Main interacting RNAs | N.A. | RBP type | Non-canonical_RBPs |
| Summary | The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013] | ||||
ENSG00000196396 Expression In 33 Tumors
| Ensembl ID | Gene symbol | Log2 Foldchange | Pvaue | Cancer |
|---|---|---|---|---|
| ENSG00000196396 | 0.50 | 2.20e-12 | KIRC | |
| ENSG00000196396 | 0.90 | 1.55e-25 | BRCA | |
| ENSG00000196396 | -0.7 | 7.38e-29 | LUSC | |
| ENSG00000196396 | 0.91 | 2.34e-15 | KIRP | |
| ENSG00000196396 | -1.0 | 2.03e-43 | LUAD |
| Ensembl ID | Gene symbol | Cancer types | Pubmed ID |
|---|---|---|---|
| ENSG00000196396 | tumor | 10023672 | |
| ENSG00000196396 | tumors | 10815905 | |
| ENSG00000196396 | cancer | 10816386 | |
| ENSG00000196396 | breast cancer | 11007774 | |
| ENSG00000196396 | cancer | 12028501 | |
| ENSG00000196396 | tumors | 12417041 | |
| ENSG00000196396 | cancer | 12554649 | |
| ENSG00000196396 | tumors | 12883693 | |
| ENSG00000196396 | stomach cancer | 12907755 | |
| ENSG00000196396 | tumor | 14766979 | |
| ENSG00000196396 | tumors | 15044856 | |
| ENSG00000196396 | gastric cancer | 15701848 | |
| ENSG00000196396 | ovarian cancers | 15880741 | |
| ENSG00000196396 | cancer | 16198645 | |
| ENSG00000196396 | cancer | 16209522 | |
| ENSG00000196396 | tumors | 16267035 | |
| ENSG00000196396 | prostate cancer | 16652382 | |
| ENSG00000196396 | cancer | 16919785 | |
| ENSG00000196396 | Cancer | 17035054 | |
| ENSG00000196396 | cancer | 17039461 | |
| ENSG00000196396 | tumors | 17143621 | |
| ENSG00000196396 | breast cancer | 17259984 | |
| ENSG00000196396 | cancer | 17279797 | |
| ENSG00000196396 | breast cancer | 17347513 | |
| ENSG00000196396 | breast cancer | 17349579 | |
| ENSG00000196396 | cancer | 17563729 | |
| ENSG00000196396 | colon cancer | 17974954 | |
| ENSG00000196396 | cancer | 18067579 | |
| ENSG00000196396 | breast cancer | 18183590 | |
| ENSG00000196396 | cancer | 18236007 | |
| ENSG00000196396 | tumor | 18259840 | |
| ENSG00000196396 | breast cancer | 18317580 | |
| ENSG00000196396 | breast cancer | 18332219 | |
| ENSG00000196396 | cancer | 18387954 | |
| ENSG00000196396 | cancer | 19012396 | |
| ENSG00000196396 | cancer | 19091943 | |
| ENSG00000196396 | cancer | 19288492 | |
| ENSG00000196396 | tumor | 19370169 | |
| ENSG00000196396 | HNSCC | 19430297 | |
| ENSG00000196396 | breast cancer | 19435911 | |
| ENSG00000196396 | tumor | 19609293 | |
| ENSG00000196396 | tumors | 19635455 | |
| ENSG00000196396 | cancer | 19782770 | |
| ENSG00000196396 | breast cancer | 19836230 | |
| ENSG00000196396 | tumor | 19936768 | |
| ENSG00000196396 | cancer | 20000419 | |
| ENSG00000196396 | cancer | 20011591 | |
| ENSG00000196396 | breast cancer | 20059965 | |
| ENSG00000196396 | breast cancer | 20381358 | |
| ENSG00000196396 | gastric cancer | 20388125 | |
| ENSG00000196396 | tumor | 20428235 | |
| ENSG00000196396 | tumor | 20504764 | |
| ENSG00000196396 | breast cancer | 20572251 | |
| ENSG00000196396 | tumor | 20707194 | |
| ENSG00000196396 | tumors | 20842227 | |
| ENSG00000196396 | breast cancer | 20952588 | |
| ENSG00000196396 | tumor | 21119599 | |
| ENSG00000196396 | tumor | 21135139 | |
| ENSG00000196396 | cancer | 21426149 | |
| ENSG00000196396 | gastric cancer | 21442314 | |
| ENSG00000196396 | breast cancer | 21630024 | |
| ENSG00000196396 | tumor | 21849469 | |
| ENSG00000196396 | cancer | 22133022 | |
| ENSG00000196396 | cancer | 22203966 | |
| ENSG00000196396 | prostate cancer | 22282656 | |
| ENSG00000196396 | cancer | 22308688 | |
| ENSG00000196396 | tumor | 22450318 | |
| ENSG00000196396 | cancer | 22477519 | |
| ENSG00000196396 | ovarian cancer | 22582758 | |
| ENSG00000196396 | cancer | 22741586 | |
| ENSG00000196396 | tumor | 22789536 | |
| ENSG00000196396 | colon tumor | 22822354 | |
| ENSG00000196396 | breast cancer | 22962253 | |
| ENSG00000196396 | tumor | 22962263 | |
| ENSG00000196396 | breast cancer | 23022281 | |
| ENSG00000196396 | breast cancer | 23036105 | |
| ENSG00000196396 | cancer | 23085163 | |
| ENSG00000196396 | cancer | 23121648 | |
| ENSG00000196396 | cancer | 23126191 | |
| ENSG00000196396 | cancer | 23139594 | |
| ENSG00000196396 | breast cancer | 23242616 | |
| ENSG00000196396 | cancer | 23274914 | |
| ENSG00000196396 | Breast Cancer | 23275709 | |
| ENSG00000196396 | colorectal cancer | 23280316 | |
| ENSG00000196396 | tumour | 23348582 | |
| ENSG00000196396 | breast cancer | 23358729 | |
| ENSG00000196396 | tumors | 23580575 | |
| ENSG00000196396 | tumor | 23814025 | |
| ENSG00000196396 | ovarian cancer | 23814047 | |
| ENSG00000196396 | cancer | 23879520 | |
| ENSG00000196396 | colorectal cancer | 23990346 | |
| ENSG00000196396 | cancer | 23994026 | |
| ENSG00000196396 | cancer | 24047800 | |
| ENSG00000196396 | Pancreatic cancer | 24123012 | |
| ENSG00000196396 | cancer | 24366088 | |
| ENSG00000196396 | cancer | 24387659 | |
| ENSG00000196396 | cancer | 24391355 | |
| ENSG00000196396 | non-small-cell lung cancer | 24417921 | |
| ENSG00000196396 | colon cancer | 24465712 | |
| ENSG00000196396 | lymphoid cancers | 24706663 | |
| ENSG00000196396 | tumor | 24715221 | |
| ENSG00000196396 | cancer | 24719298 | |
| ENSG00000196396 | tumor | 24809452 | |
| ENSG00000196396 | breast cancer | 24815008 | |
| ENSG00000196396 | tumor | 24845231 | |
| ENSG00000196396 | breast cancer | 24913037 | |
| ENSG00000196396 | tumour | 25130259 | |
| ENSG00000196396 | cancer | 25137153 | |
| ENSG00000196396 | breast cancer | 25220640 | |
| ENSG00000196396 | tumor | 25263441 | |
| ENSG00000196396 | cancer | 25364621 | |
| ENSG00000196396 | gastric cancer | 25590580 | |
| ENSG00000196396 | non-small cell lung cancer | 25617799 | |
| ENSG00000196396 | cancer | 25805211 | |
| ENSG00000196396 | cancers | 25894283 | |
| ENSG00000196396 | cancer | 26075871 | |
| ENSG00000196396 | cancer | 26091075 | |
| ENSG00000196396 | tumor | 26260902 | |
| ENSG00000196396 | tumor | 26337385 | |
| ENSG00000196396 | breast cancer | 26388336 | |
| ENSG00000196396 | cancer | 26396684 | |
| ENSG00000196396 | cancer | 26461422 | |
| ENSG00000196396 | DLBCL | 26654227 | |
| ENSG00000196396 | cancer | 26711144 | |
| ENSG00000196396 | tumor | 26755347 | |
| ENSG00000196396 | tumor | 26840794 | |
| ENSG00000196396 | cancer | 26841168 | |
| ENSG00000196396 | ovarian cancer | 26861122 | |
| ENSG00000196396 | cancers | 26865097 | |
| ENSG00000196396 | colorectal cancer | 26942883 | |
| ENSG00000196396 | tumor | 27013923 | |
| ENSG00000196396 | Prostate Cancers | 27020859 | |
| ENSG00000196396 | colon cancer | 27095436 | |
| ENSG00000196396 | tumor | 27308433 | |
| ENSG00000196396 | tumour | 27323329 | |
| ENSG00000196396 | breast cancer | 27465552 | |
| ENSG00000196396 | breast cancer | 27548130 | |
| ENSG00000196396 | DLBCL | 27600067 | |
| ENSG00000196396 | tumor | 27752061 | |
| ENSG00000196396 | tumor | 27824079 | |
| ENSG00000196396 | Breast Cancer | 27840578 | |
| ENSG00000196396 | Thyroid Tumors | 27855221 | |
| ENSG00000196396 | cancer | 27890939 | |
| ENSG00000196396 | tumor | 28038441 | |
| ENSG00000196396 | tumor | 28082443 | |
| ENSG00000196396 | cancer | 28140583 | |
| ENSG00000196396 | cancer | 28212750 | |
| ENSG00000196396 | cancer | 28318895 | |
| ENSG00000196396 | breast cancer | 28378571 | |
| ENSG00000196396 | cancer | 28492548 | |
| ENSG00000196396 | Breast Cancer | 28551626 | |
| ENSG00000196396 | cancer | 28569147 | |
| ENSG00000196396 | cancers | 28656243 | |
| ENSG00000196396 | breast cancer | 28662582 | |
| ENSG00000196396 | tumor | 28680757 | |
| ENSG00000196396 | tumor | 28807715 | |
| ENSG00000196396 | cancer | 28834433 | |
| ENSG00000196396 | Breast Cancer | 28870898 | |
| ENSG00000196396 | breast cancer | 28933366 | |
| ENSG00000196396 | tumor | 28994534 | |
| ENSG00000196396 | tumor | 29122767 | |
| ENSG00000196396 | cancer | 29186763 | |
| ENSG00000196396 | cancer | 29196128 | |
| ENSG00000196396 | cancer | 29216799 | |
| ENSG00000196396 | cancers | 29235148 | |
| ENSG00000196396 | cancer | 29257069 | |
| ENSG00000196396 | tumor | 29385181 | |
| ENSG00000196396 | cancer | 29441120 | |
| ENSG00000196396 | cancer | 29525218 | |
| ENSG00000196396 | cancer | 29533213 | |
| ENSG00000196396 | tumor | 29558404 | |
| ENSG00000196396 | cancer | 29608303 | |
| ENSG00000196396 | tumor | 29652789 | |
| ENSG00000196396 | cancer | 29705509 | |
| ENSG00000196396 | tumor | 29743567 | |
| ENSG00000196396 | colon cancer | 29743988 | |
| ENSG00000196396 | ovarian cancer | 29920310 | |
| ENSG00000196396 | ovarian cancer | 29928877 | |
| ENSG00000196396 | benign tumors | 30001383 | |
| ENSG00000196396 | cancer | 30160205 | |
| ENSG00000196396 | tumour | 30223019 | |
| ENSG00000196396 | breast cancer | 30247891 | |
| ENSG00000196396 | breast cancer | 30258080 | |
| ENSG00000196396 | breast cancer | 30360441 | |
| ENSG00000196396 | breast cancer | 30548198 | |
| ENSG00000196396 | breast cancers | 30558204 | |
| ENSG00000196396 | breast cancer | 30584278 | |
| ENSG00000196396 | cancer | 30704618 | |
| ENSG00000196396 | cancer | 30711953 | |
| ENSG00000196396 | breast cancer | 30805963 | |
| ENSG00000196396 | cancer | 31041978 | |
| ENSG00000196396 | tumor | 31048362 | |
| ENSG00000196396 | cancer | 31173266 | |
| ENSG00000196396 | cancer | 31261776 | |
| ENSG00000196396 | lung cancer | 31262859 | |
| ENSG00000196396 | DLBCL | 31331250 | |
| ENSG00000196396 | cancer, liver | 31339082 | |
| ENSG00000196396 | breast cancer | 31419504 | |
| ENSG00000196396 | cancer | 31438997 | |
| ENSG00000196396 | Gastric Cancer | 31441000 | |
| ENSG00000196396 | Cancer | 31446553 | |
| ENSG00000196396 | Cancer | 31484460 | |
| ENSG00000196396 | cancer | 31491569 | |
| ENSG00000196396 | cancer | 31494471 | |
| ENSG00000196396 | tumor | 31527306 | |
| ENSG00000196396 | Breast Cancer | 31652764 | |
| ENSG00000196396 | tumor | 31695578 | |
| ENSG00000196396 | pancreatic cancer | 31745071 | |
| ENSG00000196396 | tumor | 31803360 | |
| ENSG00000196396 | cancer | 31808495 | |
| ENSG00000196396 | tumor | 31837707 | |
| ENSG00000196396 | breast cancer | 31960729 | |
| ENSG00000196396 | breast cancer | 7905928 | |
| ENSG00000196396 | tumor | 7949181 | |
| ENSG00000196396 | tumors | 8097963 | |
| ENSG00000196396 | tumors | 8166206 | |
| ENSG00000196396 | ovarian cancer | 8626139 | |
| ENSG00000196396 | tumors | 8640675 | |
| ENSG00000196396 | tumors | 8758909 | |
| ENSG00000196396 | tumors | 9404849 | |
| ENSG00000196396 | tumors | 9826659 |
| Ensembl ID | Gene symbol | Disease/phenotype | Mutation type | Mutated / Total samples | Literature |
|---|
| Ensembl ID | Gene symbol | Cancer | P-value | Which worse | show |
|---|---|---|---|---|---|
| ENSG00000196396 | MESO | 0.0075 | high | ||
| ENSG00000196396 | SARC | 0.023 | high | ||
| ENSG00000196396 | UCEC | 0.0068 | high | ||
| ENSG00000196396 | THCA | 0.0064 | high | ||
| ENSG00000196396 | LUSC | 0.015 | high | ||
| ENSG00000196396 | HNSC | 0.038 | high | ||
| ENSG00000196396 | THYM | 0.0031 | high | ||
| ENSG00000196396 | ESCA | 0.033 | low | ||
| ENSG00000196396 | OV | 0.006 | high | ||
| ENSG00000196396 | KIRC | 0.00024 | high | ||
| ENSG00000196396 | TGCT | 0.0036 | low | ||
| ENSG00000196396 | BLCA | 0.022 | high | ||
| ENSG00000196396 | SKCM | 0.0057 | low | ||
| ENSG00000196396 | CESC | 0.05 | low | ||
| ENSG00000196396 | LIHC | 0.0047 | high |
| Ensembl ID | Gene symbol | Cancer | CNV type | -log10(q-value) | G-score | average amplitude | frequency |
|---|---|---|---|---|---|---|---|
| ENSG00000196396 | LAML | Del | 0.831320 | 0.032876 | 0.745788 | 0.020942 | |
| ENSG00000196396 | LUAD | Amp | 0.609174 | 0.113938 | 0.431748 | 0.432171 | |
| ENSG00000196396 | READ | Amp | 1.357261 | 0.158982 | 1.295250 | 0.890909 | |
| ENSG00000196396 | COAD | Amp | 5.362373 | 0.146421 | 1.198023 | 0.725055 | |
| ENSG00000196396 | BRCA | Amp | 15.654363 | 0.314792 | 0.684627 | 0.484259 | |
| ENSG00000196396 | STAD | Amp | 4.100836 | 0.218921 | 0.724184 | 0.659864 | |
| ENSG00000196396 | PRAD | Amp | 0.696352 | 0.045379 | 0.389016 | 0.079268 | |
| ENSG00000196396 | UCEC | Amp | 1.221251 | 0.116303 | 0.639862 | 0.272727 | |
| ENSG00000196396 | OV | Amp | 0.928341 | 0.336745 | 0.825943 | 0.652850 |