Ensembl ID ENSG00000196367 Gene ID 8295 Accession 12347
Gene Symbol TRRAP Alias Tra1;TR-AP;DEDDFA;DFNA75;PAF400;STAF40;PAF350/400 Full Name transformation/transcription domain associated protein
Position 7 : 98877933 - 99036477 Length 158545 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

ENSG00000196367 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000196367 0.83 5.75e-14 KICH
ENSG00000196367 0.63 1.95e-12 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000196367 breast cancer 11931763
ENSG00000196367 cancer 17694078
ENSG00000196367 cancer 19787264
ENSG00000196367 tumours 20051959
ENSG00000196367 brain tumor 20085741
ENSG00000196367 prostate cancer 23056370
ENSG00000196367 tumour 23612572
ENSG00000196367 thyroid cancer 24137342
ENSG00000196367 cancer 25469243
ENSG00000196367 cancer 25887147
ENSG00000196367 cancer 26415226
ENSG00000196367 Breast Cancer 27066097
ENSG00000196367 cancer 27382434
ENSG00000196367 cancer 27602502
ENSG00000196367 cancer 27664947
ENSG00000196367 cancer 28596815
ENSG00000196367 cancers 29559617
ENSG00000196367 colon cancer 29653964
ENSG00000196367 tumor 29936929
ENSG00000196367 tumor 31034097
ENSG00000196367 Liver Cancer 31188495
ENSG00000196367 AML 31575892
ENSG00000196367 cancer 31790487
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000196367 esophageal adenocarcinoma missense_variant 8.447% (37/438) 1 entry
ENSG00000196367 breast ductal adenocarcinoma sequence_alteration 10.85% (65/599) 1 entry
ENSG00000196367 colorectal adenocarcinoma missense_variant 9.841% (149/1514) 4 entries
ENSG00000196367 melanoma frameshift_variant 18.81% (19/101) 1 entry
ENSG00000196367 colorectal adenocarcinoma stop_gained 9.841% (149/1514) 2 entries
ENSG00000196367 skin melanoma sequence_alteration 7.512% (77/1025) 3 entries
ENSG00000196367 skin melanoma stop_gained 7.512% (77/1025) 1 entry
ENSG00000196367 esophageal adenocarcinoma sequence_alteration 8.447% (37/438) 1 entry
ENSG00000196367 skin melanoma missense_variant 7.512% (77/1025) 8 entries
ENSG00000196367 colorectal adenocarcinoma sequence_alteration 9.841% (149/1514) 1 entry
ENSG00000196367 colorectal adenocarcinoma frameshift_variant 9.841% (149/1514) 2 entries
ENSG00000196367 melanoma missense_variant 18.81% (19/101) 2 entries
ENSG00000196367 basal cell carcinoma sequence_alteration 22.41% (13/58) 1 entry
ENSG00000196367 basal cell carcinoma missense_variant 22.41% (13/58) 1 entry
ENSG00000196367 bronchoalveolar adenocarcinoma missense_variant 8.696% (2/23) 1 entry
ENSG00000196367 gastric adenocarcinoma missense_variant 6.152% (43/699) 1 entry
ENSG00000196367 colon carcinoma missense_variant 25.0% (2/8) 1 entry
ENSG00000196367 bladder transitional cell carcinoma missense_variant 4.38% (6/137) 1 entry
ENSG00000196367 prostate carcinoma missense_variant 4.225% (18/426) 2 entries
ENSG00000196367 bile duct adenocarcinoma missense_variant 1.058% (2/189) 1 entry
ENSG00000196367 Merkel cell skin cancer missense_variant 10.0% (3/30) 2 entries
ENSG00000196367 clear cell renal carcinoma missense_variant 1.37% (17/1241) 3 entries
ENSG00000196367 gastric carcinoma missense_variant 13.25% (11/83) 1 entry
ENSG00000196367 head and neck squamous cell carcinoma missense_variant 0.9383% (7/746) 2 entries
ENSG00000196367 melanoma stop_gained 18.81% (19/101) 1 entry
ENSG00000196367 oral squamous cell carcinoma missense_variant 1.942% (4/206) 4 entries
ENSG00000196367 brain glioblastoma missense_variant 0.7559% (7/926) 2 entries
ENSG00000196367 papillary thyroid carcinoma missense_variant 0.5063% (2/395) 2 entries
ENSG00000196367 female breast carcinoma missense_variant 1.873% (5/267) 1 entry
ENSG00000196367 prostate carcinoma sequence_alteration 4.225% (18/426) 1 entry
ENSG00000196367 central nervous system primitive neuroectodermal neoplasm missense_variant 1.126% (5/444) 1 entry
ENSG00000196367 cecum adenocarcinoma frameshift_variant 7.634% (10/131) 1 entry
ENSG00000196367 follicular thyroid carcinoma missense_variant 7.812% (5/64) 1 entry
ENSG00000196367 melanoma sequence_alteration 18.81% (19/101) 1 entry
ENSG00000196367 pancreatic ductal adenocarcinoma missense_variant 4.051% (51/1259) 2 entries
ENSG00000196367 skin melanoma frameshift_variant 7.512% (77/1025) 1 entry
ENSG00000196367 lung adenocarcinoma sequence_alteration 4.092% (48/1173) 3 entries
ENSG00000196367 colon adenocarcinoma stop_gained 6.16% (47/763) 2 entries
ENSG00000196367 pharyngeal squamous cell carcinoma missense_variant 6.452% (2/31) 2 entries
ENSG00000196367 cecum adenocarcinoma missense_variant 7.634% (10/131) 2 entries
ENSG00000196367 squamous cell lung carcinoma missense_variant 2.471% (19/769) 2 entries
ENSG00000196367 basal cell carcinoma stop_gained 22.41% (13/58) 1 entry
ENSG00000196367 non-small cell lung carcinoma missense_variant 3.774% (2/53) 2 entries
ENSG00000196367 lung adenocarcinoma stop_gained 4.092% (48/1173) 2 entries
ENSG00000196367 small cell lung carcinoma missense_variant 2.812% (9/320) 3 entries
ENSG00000196367 Thyroid Gland Undifferentiated (Anaplastic) Carcinoma missense_variant 1.17% (2/171) 1 entry
ENSG00000196367 central nervous system primitive neuroectodermal neoplasm sequence_alteration 1.126% (5/444) 1 entry
ENSG00000196367 diffuse large B-cell lymphoma missense_variant 2.31% (7/303) 2 entries
ENSG00000196367 acute myeloid leukemia missense_variant 1.542% (14/908) 1 entry
ENSG00000196367 colon adenocarcinoma frameshift_variant 6.16% (47/763) 1 entry
ENSG00000196367 mucosal melanoma missense_variant 14.29% (2/14) 1 entry
ENSG00000196367 clear cell renal carcinoma sequence_alteration 1.37% (17/1241) 1 entry
ENSG00000196367 endometrial carcinoma missense_variant 8.696% (2/23) 1 entry
ENSG00000196367 diffuse gastric adenocarcinoma missense_variant 2.532% (2/79) 2 entries
ENSG00000196367 gastric adenocarcinoma sequence_alteration 6.152% (43/699) 1 entry
ENSG00000196367 prostate adenocarcinoma sequence_alteration 4.399% (64/1455) 2 entries
ENSG00000196367 esophageal squamous cell carcinoma missense_variant 2.667% (18/675) 5 entries
ENSG00000196367 hepatocellular carcinoma missense_variant 2.323% (21/904) 1 entry
ENSG00000196367 hairy cell leukemia missense_variant 9.524% (2/21) 1 entry
ENSG00000196367 colon adenocarcinoma missense_variant 6.16% (47/763) 6 entries
ENSG00000196367 colon adenocarcinoma sequence_alteration 6.16% (47/763) 3 entries
ENSG00000196367 nasopharyngeal squamous cell carcinoma missense_variant 2.395% (4/167) 1 entry
ENSG00000196367 breast carcinoma missense_variant 1.488% (21/1411) 2 entries
ENSG00000196367 gastric intestinal type adenocarcinoma missense_variant 8.235% (7/85) 2 entries
ENSG00000196367 ovarian serous adenocarcinoma missense_variant 1.297% (9/694) 3 entries
ENSG00000196367 prostate adenocarcinoma missense_variant 4.399% (64/1455) 2 entries
ENSG00000196367 Ampulla of Vater Carcinoma missense_variant 2.03% (4/197) 1 entry
ENSG00000196367 rectal adenocarcinoma missense_variant 2.715% (6/221) 3 entries
ENSG00000196367 HER2 Positive Breast Carcinoma missense_variant 12.96% (14/108) 3 entries
ENSG00000196367 lung adenocarcinoma missense_variant 4.092% (48/1173) 7 entries
ENSG00000196367 Central Nervous System Lymphoma missense_variant 11.11% (1/9) 1 entry
ENSG00000196367 diffuse gastric adenocarcinoma sequence_alteration 2.532% (2/79) 1 entry
ENSG00000196367 osteosarcoma missense_variant 1.724% (2/116) 1 entry
ENSG00000196367 Adamantinomatous Craniopharyngioma stop_gained 8.333% (1/12) 1 entry
ENSG00000196367 breast carcinoma conservative_inframe_deletion 1.488% (21/1411) 1 entry
ENSG00000196367 marginal zone B-cell lymphoma missense_variant 13.33% (2/15) 1 entry
ENSG00000196367 colonic neoplasm missense_variant 6.667% (1/15) 1 entry
ENSG00000196367 pseudomyxoma peritonei missense_variant 10.0% (1/10) 1 entry
ENSG00000196367 Gallbladder Adenocarcinoma missense_variant 1.149% (1/87) 1 entry
ENSG00000196367 Thymic Squamous Cell Carcinoma missense_variant 25.0% (1/4) 1 entry
ENSG00000196367 B-cell acute lymphoblastic leukemia missense_variant 1.852% (1/54) 1 entry
ENSG00000196367 neoplasm missense_variant 3.571% (1/28) 1 entry
ENSG00000196367 medulloblastoma missense_variant 4.167% (1/24) 1 entry
ENSG00000196367 acute lymphoblastic leukemia stop_gained 0.6079% (2/329) 1 entry
ENSG00000196367 rectal adenocarcinoma stop_gained 2.715% (6/221) 1 entry
ENSG00000196367 Brain Stem Glioblastoma sequence_alteration 1.786% (1/56) 1 entry
ENSG00000196367 clear cell renal carcinoma stop_gained 1.37% (17/1241) 1 entry
ENSG00000196367 synovial sarcoma missense_variant 12.5% (1/8) 1 entry
ENSG00000196367 marginal zone B-cell lymphoma sequence_alteration 13.33% (2/15) 1 entry
ENSG00000196367 bladder transitional cell carcinoma sequence_alteration 4.38% (6/137) 1 entry
ENSG00000196367 large cell lung carcinoma missense_variant 4.167% (1/24) 1 entry
ENSG00000196367 adenosquamous lung carcinoma missense_variant 9.091% (1/11) 1 entry
ENSG00000196367 acute lymphoblastic leukemia missense_variant 0.6079% (2/329) 1 entry
ENSG00000196367 rectum adenoma missense_variant 33.33% (1/3) 1 entry
ENSG00000196367 bone osteosarcoma sequence_alteration 33.33% (1/3) 1 entry
ENSG00000196367 metaplastic breast carcinoma missense_variant 3.922% (2/51) 1 entry
ENSG00000196367 Cortisol-Producing Adrenal Cortex Adenoma missense_variant 0.8065% (1/124) 1 entry
ENSG00000196367 Malignant Germ Cell Tumor missense_variant 100.0% (1/1) 1 entry
ENSG00000196367 adrenal cortex carcinoma missense_variant 0.6098% (1/164) 1 entry
ENSG00000196367 head and neck squamous cell carcinoma sequence_alteration 0.9383% (7/746) 1 entry
ENSG00000196367 salivary gland adenoid cystic carcinoma missense_variant 1.961% (1/51) 1 entry
ENSG00000196367 ovarian serous adenocarcinoma sequence_alteration 1.297% (9/694) 1 entry
ENSG00000196367 papillary renal cell carcinoma missense_variant 0.2801% (1/357) 1 entry
ENSG00000196367 osteosarcoma sequence_alteration 1.724% (2/116) 1 entry
ENSG00000196367 angiosarcoma missense_variant 7.692% (1/13) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000196367 MESO 0.0025 high
ENSG00000196367 SARC 0.034 high
ENSG00000196367 CHOL 0.041 low
ENSG00000196367 UVM 0.011 high
ENSG00000196367 UCEC 0.018 high
ENSG00000196367 LGG 0.00025 high
ENSG00000196367 LUSC 0.04 low
ENSG00000196367 READ 0.029 low
ENSG00000196367 LUAD 0.044 low
ENSG00000196367 PCPG 0.016 low
ENSG00000196367 THYM 0.0098 low
ENSG00000196367 COAD 0.033 high
ENSG00000196367 ESCA 0.02 low
ENSG00000196367 OV 0.0025 high
ENSG00000196367 KIRC 0.00075 low
ENSG00000196367 LAML 0.0021 low
ENSG00000196367 CESC 0.028 high
ENSG00000196367 LIHC 0.00066 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000196367 LUSC Amp 2.586359 0.251227 0.563567 0.510978
ENSG00000196367 LUAD Amp 0.687418 0.116329 0.459352 0.430233
ENSG00000196367 LGG Amp 1.410245 0.054623 0.660236 0.317739
ENSG00000196367 PAAD Amp 3.606782 0.172190 0.529086 0.304348
ENSG00000196367 ESCA Amp 9.348472 0.643639 0.814771 0.576087
ENSG00000196367 HNSC Amp 8.222562 0.252982 0.616604 0.329502
ENSG00000196367 STAD Amp 14.653849 0.399477 0.691548 0.453515
ENSG00000196367 PRAD Amp 1.895893 0.062399 0.534467 0.205285