Ensembl ID
ENSG00000196365
Gene ID
9361
Accession
9479
Gene Symbol
LONP1
Alias
LON;LONP;PIM1;hLON;LonHS;CODASS;PRSS15
Full Name
lon peptidase 1, mitochondrial
Position
19 : 5691834 - 5720572
Length
28739 bases
Strand
Minus strand
Status
Confidence
Main interacting RNAs diverse RBP type
Non-canonical_RBPs
Summary
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]
ENSG00000196365 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000196365
LONP1
0.63
6.77e-22
BRCA
ENSG00000196365
LONP1
0.85
1.70e-12
COAD
ENSG00000196365
LONP1
1.40
1.53e-43
KICH
ENSG00000196365
LONP1
0.66
3.54e-14
LUSC
ENSG00000196365
LONP1
-2.2
6.08e-11
PCPG
ENSG00000196365
LONP1
1.06
1.41e-16
UCEC
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000196365
LONP1
tumor
25017063
ENSG00000196365
LONP1
cancer
27308364
ENSG00000196365
LONP1
GBM
27764809
ENSG00000196365
LONP1
cancer
30120231
ENSG00000196365
LONP1
Pancreatic Cancer
31091208
ENSG00000196365
LONP1
cancer
31387295
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000196365
LONP1
MESO
0.025
high
show
ENSG00000196365
LONP1
STAD
0.011
low
show
ENSG00000196365
LONP1
CHOL
0.033
high
show
ENSG00000196365
LONP1
PAAD
0.0081
low
show
ENSG00000196365
LONP1
ACC
0.028
high
show
ENSG00000196365
LONP1
LUSC
0.0016
low
show
ENSG00000196365
LONP1
BRCA
0.0015
high
show
ENSG00000196365
LONP1
COAD
0.047
low
show
ENSG00000196365
LONP1
DLBC
0.032
low
show
ENSG00000196365
LONP1
KIRC
0.033
high
show
ENSG00000196365
LONP1
BLCA
0.048
high
show
ENSG00000196365
LONP1
SKCM
0.0014
high
show
ENSG00000196365
LONP1
LIHC
0.0026
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000196365
LONP1
LUSC
Del
2.752573
0.091625
0.341155
0.405190
ENSG00000196365
LONP1
LUAD
Del
1.838450
0.065672
0.345319
0.538760
ENSG00000196365
LONP1
CESC
Del
10.003789
0.176160
0.463930
0.345763
ENSG00000196365
LONP1
UCS
Del
6.788839
0.556791
0.602432
0.696429
ENSG00000196365
LONP1
PAAD
Del
1.993935
0.071196
0.350948
0.179348
ENSG00000196365
LONP1
ESCA
Del
1.170607
0.110030
0.329148
0.472826
ENSG00000196365
LONP1
HNSC
Del
5.643518
0.096443
0.332222
0.285441
ENSG00000196365
LONP1
LIHC
Del
4.675987
0.117921
0.461135
0.232432
ENSG00000196365
LONP1
BLCA
Del
2.250772
0.101896
0.324664
0.345588
ENSG00000196365
LONP1
BRCA
Del
2.859965
0.080497
0.358436
0.261111
ENSG00000196365
LONP1
STAD
Del
2.027184
0.078805
0.352746
0.349206
ENSG00000196365
LONP1
UCEC
Del
33.135911
0.221552
0.587595
0.256030
ENSG00000196365
LONP1
OV
Del
67.562949
0.651834
0.635937
0.706390
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