Ensembl ID ENSG00000196305 Gene ID 3376 Accession 5330
Gene Symbol IARS1 Alias IRS;IARS;ILRS;ILERS;GRIDHH;PRO0785 Full Name isoleucyl-tRNA synthetase 1
Position 9 : 92210207 - 92293854 Length 83648 bases Strand Minus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]

ENSG00000196305 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000196305 IARS1 0.49 1.00e-18 BRCA
ENSG00000196305 IARS1 1.10 8.56e-50 COAD
ENSG00000196305 IARS1 0.99 1.91e-11 READ
ENSG00000196305 IARS1 0.91 7.63e-27 LUSC
ENSG00000196305 IARS1 0.60 6.79e-12 LIHC
ENSG00000196305 IARS1 0.74 1.89e-25 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000196305 IARS1 breast cancer 10543935
ENSG00000196305 IARS1 tumor 10873042
ENSG00000196305 IARS1 colorectal cancer 10916943
ENSG00000196305 IARS1 tumor 11071655
ENSG00000196305 IARS1 cancer 11120395
ENSG00000196305 IARS1 tumor 11150371
ENSG00000196305 IARS1 tumors 11413538
ENSG00000196305 IARS1 tumors 11481652
ENSG00000196305 IARS1 breast cancer 12082548
ENSG00000196305 IARS1 tumour 12466032
ENSG00000196305 IARS1 pancreatic cancer 14604996
ENSG00000196305 IARS1 breast cancer 14669790
ENSG00000196305 IARS1 tumours 14970859
ENSG00000196305 IARS1 cancer 15234036
ENSG00000196305 IARS1 mammary cancer 15242314
ENSG00000196305 IARS1 tumor 15249583
ENSG00000196305 IARS1 tumor 15312349
ENSG00000196305 IARS1 breast cancer 15509777
ENSG00000196305 IARS1 tumor 16000571
ENSG00000196305 IARS1 tumor 16029816
ENSG00000196305 IARS1 cancer 16030120
ENSG00000196305 IARS1 pancreatic cancer 16230374
ENSG00000196305 IARS1 tumours 16404430
ENSG00000196305 IARS1 tumor 16438724
ENSG00000196305 IARS1 breast cancer 16450000
ENSG00000196305 IARS1 cancer 16625210
ENSG00000196305 IARS1 cancer 17030631
ENSG00000196305 IARS1 breast cancer 17043687
ENSG00000196305 IARS1 breast cancer 17051426
ENSG00000196305 IARS1 tumor 17084557
ENSG00000196305 IARS1 cancer 17334390
ENSG00000196305 IARS1 tumors 17361103
ENSG00000196305 IARS1 cancer 17428006
ENSG00000196305 IARS1 breast cancer 17848740
ENSG00000196305 IARS1 tumours 18195709
ENSG00000196305 IARS1 tumors 18231572
ENSG00000196305 IARS1 pancreatic cancer 18316392
ENSG00000196305 IARS1 invasive breast cancer 18513385
ENSG00000196305 IARS1 tumour 18627608
ENSG00000196305 IARS1 breast cancer 18819936
ENSG00000196305 IARS1 cancer 19140314
ENSG00000196305 IARS1 invasive breast cancer 19527488
ENSG00000196305 IARS1 cancer 19534786
ENSG00000196305 IARS1 tumour 19602265
ENSG00000196305 IARS1 tumour 19664236
ENSG00000196305 IARS1 tumour 19706168
ENSG00000196305 IARS1 cancer 19737943
ENSG00000196305 IARS1 tumor 19920186
ENSG00000196305 IARS1 cancer 20179300
ENSG00000196305 IARS1 tumor 20181247
ENSG00000196305 IARS1 tumor 20401916
ENSG00000196305 IARS1 breast cancer 20461080
ENSG00000196305 IARS1 prostate cancer 20534149
ENSG00000196305 IARS1 liver tumors 20569442
ENSG00000196305 IARS1 tumours 20648017
ENSG00000196305 IARS1 pancreatic cancer 20663861
ENSG00000196305 IARS1 tumour 2086335
ENSG00000196305 IARS1 cancers 20966354
ENSG00000196305 IARS1 tumor 21034938
ENSG00000196305 IARS1 pancreatic cancer 21183737
ENSG00000196305 IARS1 prostate cancer 21387109
ENSG00000196305 IARS1 cancer 21597332
ENSG00000196305 IARS1 tumour 21639893
ENSG00000196305 IARS1 tumour 21857648
ENSG00000196305 IARS1 cancer 21975032
ENSG00000196305 IARS1 tumor 22028198
ENSG00000196305 IARS1 vulvar cancer 22029821
ENSG00000196305 IARS1 tumor 22313682
ENSG00000196305 IARS1 cervical cancer 22475274
ENSG00000196305 IARS1 gastroenteropancreatic neuroendocrine tumors 22558472
ENSG00000196305 IARS1 tumors 22645475
ENSG00000196305 IARS1 tumor 22658715
ENSG00000196305 IARS1 tumor 22675642
ENSG00000196305 IARS1 cancer 22704344
ENSG00000196305 IARS1 colon cancer 22745574
ENSG00000196305 IARS1 cancers 22788551
ENSG00000196305 IARS1 breast cancer 22920283
ENSG00000196305 IARS1 tumors 23053896
ENSG00000196305 IARS1 breast cancer 23199901
ENSG00000196305 IARS1 cancers 23251408
ENSG00000196305 IARS1 Tumor 23273263
ENSG00000196305 IARS1 tumor 23358800
ENSG00000196305 IARS1 cancer 23365645
ENSG00000196305 IARS1 tumor 23393326
ENSG00000196305 IARS1 tumour 23403819
ENSG00000196305 IARS1 breast cancer 23420497
ENSG00000196305 IARS1 tumor 23454747
ENSG00000196305 IARS1 cancer 23562473
ENSG00000196305 IARS1 tumor 23627572
ENSG00000196305 IARS1 tumors 23651636
ENSG00000196305 IARS1 tumor 23717101
ENSG00000196305 IARS1 Colon cancer 23762846
ENSG00000196305 IARS1 tumor 23807662
ENSG00000196305 IARS1 tumor 2380887
ENSG00000196305 IARS1 pancreatic cancer 23834149
ENSG00000196305 IARS1 tumour 23857870
ENSG00000196305 IARS1 breast cancer 23877285
ENSG00000196305 IARS1 benign tumors 23907947
ENSG00000196305 IARS1 tumor 2391558
ENSG00000196305 IARS1 tumor 24045440
ENSG00000196305 IARS1 tumor 24085552
ENSG00000196305 IARS1 tumor 24209510
ENSG00000196305 IARS1 tumor 24349057
ENSG00000196305 IARS1 tumours 24632604
ENSG00000196305 IARS1 Tumors 24637962
ENSG00000196305 IARS1 tumors 24952873
ENSG00000196305 IARS1 tumour 24990399
ENSG00000196305 IARS1 breast cancer 25061488
ENSG00000196305 IARS1 tumours 25153719
ENSG00000196305 IARS1 tumor 25168354
ENSG00000196305 IARS1 cancer 25240521
ENSG00000196305 IARS1 tumor 25255861
ENSG00000196305 IARS1 prostate cancer 25267499
ENSG00000196305 IARS1 cancer 25329702
ENSG00000196305 IARS1 tumors 25355716
ENSG00000196305 IARS1 cancer 25356869
ENSG00000196305 IARS1 cancer 25371063
ENSG00000196305 IARS1 tumors 25465919
ENSG00000196305 IARS1 tumor 2548177
ENSG00000196305 IARS1 lung cancer 25820822
ENSG00000196305 IARS1 cancers 25888634
ENSG00000196305 IARS1 tumor 25927440
ENSG00000196305 IARS1 tumor 25986346
ENSG00000196305 IARS1 prostate cancer 26029165
ENSG00000196305 IARS1 cancer 26074875
ENSG00000196305 IARS1 cancer 26134500
ENSG00000196305 IARS1 breast cancer 26219409
ENSG00000196305 IARS1 cancer 26222696
ENSG00000196305 IARS1 tumors 26259237
ENSG00000196305 IARS1 cancer 26364612
ENSG00000196305 IARS1 cancer 26445041
ENSG00000196305 IARS1 tumour 26461054
ENSG00000196305 IARS1 cancer 26557909
ENSG00000196305 IARS1 tumours 26579243
ENSG00000196305 IARS1 secondary cancer 26646016
ENSG00000196305 IARS1 tumor 26652716
ENSG00000196305 IARS1 tumor 26774699
ENSG00000196305 IARS1 tumor 26809958
ENSG00000196305 IARS1 tumor 26843617
ENSG00000196305 IARS1 tumour 26882066
ENSG00000196305 IARS1 tumor 26933815
ENSG00000196305 IARS1 metastatic tumors 26948660
ENSG00000196305 IARS1 prostate cancer 26956053
ENSG00000196305 IARS1 cancers 26959890
ENSG00000196305 IARS1 breast cancer 26991655
ENSG00000196305 IARS1 tumor 27009855
ENSG00000196305 IARS1 breast cancers 27048245
ENSG00000196305 IARS1 cancer 27058425
ENSG00000196305 IARS1 cancers 27304907
ENSG00000196305 IARS1 tumors 27421134
ENSG00000196305 IARS1 tumors 27467270
ENSG00000196305 IARS1 tumor 27473057
ENSG00000196305 IARS1 cancer 27475906
ENSG00000196305 IARS1 Cancer 2747593
ENSG00000196305 IARS1 cancer 27485939
ENSG00000196305 IARS1 tumor 27556502
ENSG00000196305 IARS1 cervical cancer 27698799
ENSG00000196305 IARS1 breast cancer 27765041
ENSG00000196305 IARS1 metastatic tumors 27842508
ENSG00000196305 IARS1 breast cancer 27876799
ENSG00000196305 IARS1 tumor 28081183
ENSG00000196305 IARS1 tumor 28104913
ENSG00000196305 IARS1 tumor 28143530
ENSG00000196305 IARS1 cancer 28234626
ENSG00000196305 IARS1 cervical cancer 28241481
ENSG00000196305 IARS1 metastatic colorectal cancer 28369940
ENSG00000196305 IARS1 cancer 28400705
ENSG00000196305 IARS1 cancer 28416766
ENSG00000196305 IARS1 breast cancer 28427429
ENSG00000196305 IARS1 tumor 28454227
ENSG00000196305 IARS1 cancer 28472109
ENSG00000196305 IARS1 tumor 28600491
ENSG00000196305 IARS1 Cancer 28632777
ENSG00000196305 IARS1 cervical cancer 28753926
ENSG00000196305 IARS1 tumors 28952025
ENSG00000196305 IARS1 tumors 29069791
ENSG00000196305 IARS1 tumors 29163802
ENSG00000196305 IARS1 tumour 29212283
ENSG00000196305 IARS1 tumor 29221157
ENSG00000196305 IARS1 tumors 29282035
ENSG00000196305 IARS1 cervical cancer 29285256
ENSG00000196305 IARS1 cancer 29292367
ENSG00000196305 IARS1 tumor 29349598
ENSG00000196305 IARS1 tumors 29416719
ENSG00000196305 IARS1 bladder tumors 29445424
ENSG00000196305 IARS1 tumors 29466768
ENSG00000196305 IARS1 tumor 29492204
ENSG00000196305 IARS1 Cancer 29533008
ENSG00000196305 IARS1 breast cancer 29685905
ENSG00000196305 IARS1 lung cancer 29794965
ENSG00000196305 IARS1 breast cancer 29868002
ENSG00000196305 IARS1 tumour 29873743
ENSG00000196305 IARS1 tumors 29921891
ENSG00000196305 IARS1 prostate cancer 29952681
ENSG00000196305 IARS1 tumour 29955134
ENSG00000196305 IARS1 breast cancer 29990315
ENSG00000196305 IARS1 tumor 30007204
ENSG00000196305 IARS1 tumor 30064461
ENSG00000196305 IARS1 tumors 30103710
ENSG00000196305 IARS1 cancer 30168483
ENSG00000196305 IARS1 tumor 30170989
ENSG00000196305 IARS1 tumor 30193580
ENSG00000196305 IARS1 tumor 30214685
ENSG00000196305 IARS1 breast cancer 30229539
ENSG00000196305 IARS1 tumor 30256047
ENSG00000196305 IARS1 tumors 30326857
ENSG00000196305 IARS1 tumor 30328953
ENSG00000196305 IARS1 prostate cancer 30456317
ENSG00000196305 IARS1 tumour 30468298
ENSG00000196305 IARS1 ovarian cancer 30522488
ENSG00000196305 IARS1 Tumor 30523270
ENSG00000196305 IARS1 tumors 30669416
ENSG00000196305 IARS1 tumor 30675236
ENSG00000196305 IARS1 tumors 30737300
ENSG00000196305 IARS1 tumors 30741998
ENSG00000196305 IARS1 Tumors 30747329
ENSG00000196305 IARS1 tumor 30755598
ENSG00000196305 IARS1 tumors 30799684
ENSG00000196305 IARS1 bladder cancer 30799990
ENSG00000196305 IARS1 tumors 30813617
ENSG00000196305 IARS1 tumors 30850589
ENSG00000196305 IARS1 breast cancer 30858725
ENSG00000196305 IARS1 Tumors 30867449
ENSG00000196305 IARS1 tumor 30883338
ENSG00000196305 IARS1 tumor 30975102
ENSG00000196305 IARS1 tumor 31027243
ENSG00000196305 IARS1 cancers 31115969
ENSG00000196305 IARS1 tumor 31137694
ENSG00000196305 IARS1 tumor 31186637
ENSG00000196305 IARS1 tumors 31200683
ENSG00000196305 IARS1 tumor 31215116
ENSG00000196305 IARS1 tumor 31245296
ENSG00000196305 IARS1 pancreatic cancer 31277663
ENSG00000196305 IARS1 tumor 31395078
ENSG00000196305 IARS1 prostate cancers 31406527
ENSG00000196305 IARS1 tumor 31475113
ENSG00000196305 IARS1 pancreatic cancer 31526370
ENSG00000196305 IARS1 tumors 31531802
ENSG00000196305 IARS1 tumor 31632918
ENSG00000196305 IARS1 tumours 31656321
ENSG00000196305 IARS1 Cancer 3323176
ENSG00000196305 IARS1 meningeal tumors 3530377
ENSG00000196305 IARS1 tumour 6133317
ENSG00000196305 IARS1 Cancer 7074579
ENSG00000196305 IARS1 ovarian cancers 8135488
ENSG00000196305 IARS1 tumour 8433684
ENSG00000196305 IARS1 tumor 8600340
ENSG00000196305 IARS1 tumors 8863239
ENSG00000196305 IARS1 ovarian cancer 9009165
ENSG00000196305 IARS1 tumors 9142207
ENSG00000196305 IARS1 tumor 9240649
ENSG00000196305 IARS1 breast cancer 9545345
ENSG00000196305 IARS1 tumor 9857218
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000196305 IARS1 MESO 0.0055 high
ENSG00000196305 IARS1 SARC 0.0014 high
ENSG00000196305 IARS1 STAD 0.036 low
ENSG00000196305 IARS1 PAAD 0.043 high
ENSG00000196305 IARS1 ACC 0.00029 high
ENSG00000196305 IARS1 HNSC 0.0085 high
ENSG00000196305 IARS1 READ 0.019 low
ENSG00000196305 IARS1 KICH 0.0025 high
ENSG00000196305 IARS1 LUAD 0.01 high
ENSG00000196305 IARS1 BRCA 0.0031 high
ENSG00000196305 IARS1 KIRC 0.0016 low
ENSG00000196305 IARS1 PRAD 0.022 high
ENSG00000196305 IARS1 TGCT 0.041 high
ENSG00000196305 IARS1 BLCA 0.012 high
ENSG00000196305 IARS1 SKCM 0.042 high
ENSG00000196305 IARS1 CESC 0.035 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency