Ensembl ID ENSG00000196262 Gene ID 5478 Accession 9253
Gene Symbol PPIA Alias CYPA;CYPH;HEL-S-69p Full Name peptidylprolyl isomerase A
Position 7 : 44796680 - 44824564 Length 27885 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

ENSG00000196262 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000196262 PPIA 0.69 1.32e-35 BRCA
ENSG00000196262 PPIA 0.80 3.91e-20 COAD
ENSG00000196262 PPIA 0.61 2.20e-12 KICH
ENSG00000196262 PPIA 0.70 5.21e-15 LUSC
ENSG00000196262 PPIA 0.49 3.98e-13 PRAD
ENSG00000196262 PPIA 0.86 1.63e-22 KIRP
ENSG00000196262 PPIA 0.66 6.42e-15 LIHC
ENSG00000196262 PPIA 0.88 7.25e-28 UCEC
ENSG00000196262 PPIA 0.54 5.41e-11 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000196262 PPIA breast cancer 11807954
ENSG00000196262 PPIA lung tumor 12670919
ENSG00000196262 PPIA prostate cancer 12706369
ENSG00000196262 PPIA tumor 14526201
ENSG00000196262 PPIA lung tumor 15283571
ENSG00000196262 PPIA non-small cell lung cancer 15541816
ENSG00000196262 PPIA tumors 15604267
ENSG00000196262 PPIA lung tumor 16204056
ENSG00000196262 PPIA pancreatic cancer 16226951
ENSG00000196262 PPIA breast cancer 16280054
ENSG00000196262 PPIA pancreatic cancer 16604531
ENSG00000196262 PPIA tumors 16645950
ENSG00000196262 PPIA tumors 16773180
ENSG00000196262 PPIA tumor 16885564
ENSG00000196262 PPIA tumor 17051643
ENSG00000196262 PPIA cancer 17094902
ENSG00000196262 PPIA tumor 17150412
ENSG00000196262 PPIA cancer 17440077
ENSG00000196262 PPIA tumor 17520256
ENSG00000196262 PPIA small cell lung cancer 17678621
ENSG00000196262 PPIA cancer 17867987
ENSG00000196262 PPIA tumors 17925854
ENSG00000196262 PPIA cancers 17991918
ENSG00000196262 PPIA tumour 18042273
ENSG00000196262 PPIA tumor 18421009
ENSG00000196262 PPIA lung cancer 18653356
ENSG00000196262 PPIA breast cancer 18829531
ENSG00000196262 PPIA tumors 19014639
ENSG00000196262 PPIA tumour 19433215
ENSG00000196262 PPIA breast tumors 19544972
ENSG00000196262 PPIA breast cancer 19582718
ENSG00000196262 PPIA breast cancer 19584157
ENSG00000196262 PPIA ovarian cancer 19622337
ENSG00000196262 PPIA breast cancer 19837153
ENSG00000196262 PPIA cancer 19848416
ENSG00000196262 PPIA cancer 19865066
ENSG00000196262 PPIA tumor 20107538
ENSG00000196262 PPIA tumour 20122155
ENSG00000196262 PPIA tumors 20138823
ENSG00000196262 PPIA tumors 20454998
ENSG00000196262 PPIA cancers 20637127
ENSG00000196262 PPIA tumors 20855564
ENSG00000196262 PPIA cancer 20962430
ENSG00000196262 PPIA colon cancer 21059236
ENSG00000196262 PPIA cancers 21309470
ENSG00000196262 PPIA cancer 21565278
ENSG00000196262 PPIA tumor 21871105
ENSG00000196262 PPIA tumor 21924258
ENSG00000196262 PPIA cancer 21956400
ENSG00000196262 PPIA tumor 22089348
ENSG00000196262 PPIA tumor 22506042
ENSG00000196262 PPIA cancer 22555451
ENSG00000196262 PPIA breast cancer 22623065
ENSG00000196262 PPIA cancers 22631225
ENSG00000196262 PPIA tumor 22855186
ENSG00000196262 PPIA cancer 22906739
ENSG00000196262 PPIA non-small cell lung cancer 23031673
ENSG00000196262 PPIA lung cancer 23042266
ENSG00000196262 PPIA ovarian cancer 23554992
ENSG00000196262 PPIA tumor 23589362
ENSG00000196262 PPIA endometrial cancer 23899654
ENSG00000196262 PPIA tumours 24001041
ENSG00000196262 PPIA endometrial cancer 24036847
ENSG00000196262 PPIA tumor 24069422
ENSG00000196262 PPIA tumor 24200080
ENSG00000196262 PPIA intestinal tumor 24272759
ENSG00000196262 PPIA oral cancer 24386210
ENSG00000196262 PPIA tumor 24386293
ENSG00000196262 PPIA tumor 24392813
ENSG00000196262 PPIA cancer 24657971
ENSG00000196262 PPIA cancer 24662981
ENSG00000196262 PPIA ovarian cancer 24776823
ENSG00000196262 PPIA colorectal cancer 24859296
ENSG00000196262 PPIA tumor 24885929
ENSG00000196262 PPIA breast cancer 24957886
ENSG00000196262 PPIA cancer 25119989
ENSG00000196262 PPIA Kidney cancers 25344860
ENSG00000196262 PPIA breast cancer 25454514
ENSG00000196262 PPIA tumors 25473950
ENSG00000196262 PPIA lung cancer 25573171
ENSG00000196262 PPIA tumor 25760073
ENSG00000196262 PPIA tumor 25858032
ENSG00000196262 PPIA tumor 25881111
ENSG00000196262 PPIA tumors 25974208
ENSG00000196262 PPIA Tumor 26008617
ENSG00000196262 PPIA non-small cell lung cancer 26020957
ENSG00000196262 PPIA breast cancer 26044366
ENSG00000196262 PPIA cancer 26246468
ENSG00000196262 PPIA cancers 26384826
ENSG00000196262 PPIA cancer 26656091
ENSG00000196262 PPIA DLBCL 26752561
ENSG00000196262 PPIA tumor 26894994
ENSG00000196262 PPIA cancers 27397650
ENSG00000196262 PPIA cancer 27468721
ENSG00000196262 PPIA gastric cancer 27479192
ENSG00000196262 PPIA GBM 27565396
ENSG00000196262 PPIA cancer 27822214
ENSG00000196262 PPIA laryngeal cancer 27957397
ENSG00000196262 PPIA tumor 28299282
ENSG00000196262 PPIA tumor 28394340
ENSG00000196262 PPIA non-small cell lung cancer 28454299
ENSG00000196262 PPIA skin cancer 28789363
ENSG00000196262 PPIA malignant tumors 29027312
ENSG00000196262 PPIA non-small cell lung cancer 29110442
ENSG00000196262 PPIA cancer 29203663
ENSG00000196262 PPIA cancer 29852734
ENSG00000196262 PPIA breast cancer 29959151
ENSG00000196262 PPIA colon cancer 30384873
ENSG00000196262 PPIA Tumor 30386245
ENSG00000196262 PPIA breast cancer 30546434
ENSG00000196262 PPIA breast tumor 30844143
ENSG00000196262 PPIA cancer 31063269
ENSG00000196262 PPIA GBM 31517118
ENSG00000196262 PPIA cancer 31611978
ENSG00000196262 PPIA cancer 31783195
ENSG00000196262 PPIA ovarian cancer 31783885
ENSG00000196262 PPIA oral cancer 9989835
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000196262 PPIA MESO 0.016 high
ENSG00000196262 PPIA PAAD 0.014 high
ENSG00000196262 PPIA HNSC 0.029 high
ENSG00000196262 PPIA KIRP 0.037 high
ENSG00000196262 PPIA KICH 0.0012 high
ENSG00000196262 PPIA LUAD 0.00013 high
ENSG00000196262 PPIA PCPG 0.0016 high
ENSG00000196262 PPIA THYM 0.021 low
ENSG00000196262 PPIA ESCA 0.019 high
ENSG00000196262 PPIA OV 0.038 low
ENSG00000196262 PPIA KIRC 0.00092 high
ENSG00000196262 PPIA LAML 0.044 high
ENSG00000196262 PPIA GBM 0.023 high
ENSG00000196262 PPIA SKCM 0.0033 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency