Ensembl ID ENSG00000189091 Gene ID 23450 Accession 10770
Gene Symbol SF3B3 Alias RSE1;SAP130;SF3b130;STAF130 Full Name splicing factor 3b subunit 3
Position 16 : 70523791 - 70577668 Length 53878 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]

ENSG00000189091 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000189091 SF3B3 0.89 1.56e-45 COAD
ENSG00000189091 SF3B3 1.01 1.53e-13 READ
ENSG00000189091 SF3B3 0.76 1.08e-28 LUSC
ENSG00000189091 SF3B3 0.48 7.08e-15 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000189091 SF3B3 colorectal cancer 22496461
ENSG00000189091 SF3B3 cancer 24241165
ENSG00000189091 SF3B3 breast cancer 25424858
ENSG00000189091 SF3B3 breast cancer 25431237
ENSG00000189091 SF3B3 oral cancer 25651737
ENSG00000189091 SF3B3 breast cancer 26805938
ENSG00000189091 SF3B3 tumor 27049944
ENSG00000189091 SF3B3 Renal Cancer 27879367
ENSG00000189091 SF3B3 liver cancer 28038442
ENSG00000189091 SF3B3 cancer 28198434
ENSG00000189091 SF3B3 cancer 29497419
ENSG00000189091 SF3B3 tumours 31892336
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000189091 SF3B3 MESO 0.029 high
ENSG00000189091 SF3B3 SARC 0.0027 high
ENSG00000189091 SF3B3 CHOL 0.0077 low
ENSG00000189091 SF3B3 UVM 0.00065 low
ENSG00000189091 SF3B3 LUSC 0.043 high
ENSG00000189091 SF3B3 HNSC 0.0051 high
ENSG00000189091 SF3B3 KIRP 0.019 high
ENSG00000189091 SF3B3 THYM 0.014 low
ENSG00000189091 SF3B3 COAD 0.03 high
ENSG00000189091 SF3B3 UCS 0.012 low
ENSG00000189091 SF3B3 BLCA 0.00089 high
ENSG00000189091 SF3B3 LAML 0.04 high
ENSG00000189091 SF3B3 GBM 0.016 low
ENSG00000189091 SF3B3 LIHC 0.00015 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000189091 SF3B3 LAML Del 2.136052 0.049881 0.608754 0.036649
ENSG00000189091 SF3B3 TGCT Amp 0.748581 0.119204 0.578998 0.140000
ENSG00000189091 SF3B3 BLCA Amp 0.771550 0.166422 0.488593 0.259804
ENSG00000189091 SF3B3 PRAD Del 9.265444 0.144573 0.519035 0.327236
ENSG00000189091 SF3B3 UCEC Del 3.522859 0.077131 0.624601 0.263451
ENSG00000189091 SF3B3 OV Del 9.296978 0.293194 0.656128 0.768566