Ensembl ID
ENSG00000189091
Gene ID
23450
Accession
10770
Gene Symbol
SF3B3
Alias
RSE1;SAP130;SF3b130;STAF130
Full Name
splicing factor 3b subunit 3
Position
16 : 70523791 - 70577668
Length
53878 bases
Strand
Plus strand
Status
Confidence
Main interacting RNAs mRNA RBP type
Canonical_RBPs
Summary
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]
ENSG00000189091 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000189091
SF3B3
0.89
1.56e-45
COAD
ENSG00000189091
SF3B3
1.01
1.53e-13
READ
ENSG00000189091
SF3B3
0.76
1.08e-28
LUSC
ENSG00000189091
SF3B3
0.48
7.08e-15
LUAD
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000189091
SF3B3
colorectal cancer
22496461
ENSG00000189091
SF3B3
cancer
24241165
ENSG00000189091
SF3B3
breast cancer
25424858
ENSG00000189091
SF3B3
breast cancer
25431237
ENSG00000189091
SF3B3
oral cancer
25651737
ENSG00000189091
SF3B3
breast cancer
26805938
ENSG00000189091
SF3B3
tumor
27049944
ENSG00000189091
SF3B3
Renal Cancer
27879367
ENSG00000189091
SF3B3
liver cancer
28038442
ENSG00000189091
SF3B3
cancer
28198434
ENSG00000189091
SF3B3
cancer
29497419
ENSG00000189091
SF3B3
tumours
31892336
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000189091
SF3B3
MESO
0.029
high
show
ENSG00000189091
SF3B3
SARC
0.0027
high
show
ENSG00000189091
SF3B3
CHOL
0.0077
low
show
ENSG00000189091
SF3B3
UVM
0.00065
low
show
ENSG00000189091
SF3B3
LUSC
0.043
high
show
ENSG00000189091
SF3B3
HNSC
0.0051
high
show
ENSG00000189091
SF3B3
KIRP
0.019
high
show
ENSG00000189091
SF3B3
THYM
0.014
low
show
ENSG00000189091
SF3B3
COAD
0.03
high
show
ENSG00000189091
SF3B3
UCS
0.012
low
show
ENSG00000189091
SF3B3
BLCA
0.00089
high
show
ENSG00000189091
SF3B3
LAML
0.04
high
show
ENSG00000189091
SF3B3
GBM
0.016
low
show
ENSG00000189091
SF3B3
LIHC
0.00015
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000189091
SF3B3
LAML
Del
2.136052
0.049881
0.608754
0.036649
ENSG00000189091
SF3B3
TGCT
Amp
0.748581
0.119204
0.578998
0.140000
ENSG00000189091
SF3B3
BLCA
Amp
0.771550
0.166422
0.488593
0.259804
ENSG00000189091
SF3B3
PRAD
Del
9.265444
0.144573
0.519035
0.327236
ENSG00000189091
SF3B3
UCEC
Del
3.522859
0.077131
0.624601
0.263451
ENSG00000189091
SF3B3
OV
Del
9.296978
0.293194
0.656128
0.768566
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