Ensembl ID
ENSG00000187837
Gene ID
3006
Accession
4716
Gene Symbol
H1-2
Alias
H1C;H1.2;H1F2;H1s-1;HIST1H1C
Full Name
H1.2 linker histone, cluster member
Position
6 : 26055740 - 26056470
Length
731 bases
Strand
Minus strand
Status
Confidence
Main interacting RNAs N.A. RBP type
Non-canonical_RBPs
Summary
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
ENSG00000187837 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000187837
HIST1H1C
2.46
1.12e-13
BLCA
ENSG00000187837
HIST1H1C
2.26
1.79e-52
BRCA
ENSG00000187837
HIST1H1C
1.47
6.29e-14
LUSC
ENSG00000187837
HIST1H1C
1.44
1.20e-11
LIHC
ENSG00000187837
HIST1H1C
2.49
9.90e-21
UCEC
ENSG00000187837
HIST1H1C
1.57
6.03e-20
LUAD
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000187837
HIST1H1C
testicular germ cell cancer
12543810
ENSG00000187837
HIST1H1C
tumors
1269855
ENSG00000187837
HIST1H1C
breast cancer
16839218
ENSG00000187837
HIST1H1C
testicular germ cell tumor
17223197
ENSG00000187837
HIST1H1C
germ cell tumor
17328536
ENSG00000187837
HIST1H1C
tumour
17537454
ENSG00000187837
HIST1H1C
tumor
18852131
ENSG00000187837
HIST1H1C
germ cell tumour
22071088
ENSG00000187837
HIST1H1C
tumor
22749394
ENSG00000187837
HIST1H1C
tumors
23060558
ENSG00000187837
HIST1H1C
tumor
23112873
ENSG00000187837
HIST1H1C
breast cancer
23151675
ENSG00000187837
HIST1H1C
germ cell tumor
24215546
ENSG00000187837
HIST1H1C
DLBCL
26473533
ENSG00000187837
HIST1H1C
tumors
2691957
ENSG00000187837
HIST1H1C
tumor
27765905
ENSG00000187837
HIST1H1C
TGCT
28081228
ENSG00000187837
HIST1H1C
prostate cancer
28832499
ENSG00000187837
HIST1H1C
tumor
29029420
ENSG00000187837
HIST1H1C
breast cancer
29050075
ENSG00000187837
HIST1H1C
tumors
2964753
ENSG00000187837
HIST1H1C
breast cancer
29915250
ENSG00000187837
HIST1H1C
breast cancer
29946439
ENSG00000187837
HIST1H1C
tumor
29963023
ENSG00000187837
HIST1H1C
tumor
30718359
ENSG00000187837
HIST1H1C
Cancer
30833417
ENSG00000187837
HIST1H1C
AML
31577790
ENSG00000187837
HIST1H1C
tumor
8033621
ENSG00000187837
HIST1H1C
germ-cell cancer
8609154
ENSG00000187837
HIST1H1C
tumor
9159349
ENSG00000187837
HIST1H1C
tumour
9750020
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000187837
HIST1H1C
MESO
0.00032
low
show
ENSG00000187837
HIST1H1C
UVM
0.0053
low
show
ENSG00000187837
HIST1H1C
UCEC
0.033
low
show
ENSG00000187837
HIST1H1C
ACC
0.00037
high
show
ENSG00000187837
HIST1H1C
READ
0.024
high
show
ENSG00000187837
HIST1H1C
KIRP
0.033
high
show
ENSG00000187837
HIST1H1C
KICH
0.027
low
show
ENSG00000187837
HIST1H1C
PCPG
0.0063
low
show
ENSG00000187837
HIST1H1C
THYM
0.0015
low
show
ENSG00000187837
HIST1H1C
BRCA
0.046
low
show
ENSG00000187837
HIST1H1C
COAD
0.012
high
show
ENSG00000187837
HIST1H1C
UCS
0.0015
high
show
ENSG00000187837
HIST1H1C
OV
0.0084
low
show
ENSG00000187837
HIST1H1C
DLBC
0.00034
low
show
ENSG00000187837
HIST1H1C
KIRC
0.035
high
show
ENSG00000187837
HIST1H1C
BLCA
0.00026
low
show
ENSG00000187837
HIST1H1C
LAML
0.01
high
show
ENSG00000187837
HIST1H1C
SKCM
0.026
high
show
ENSG00000187837
HIST1H1C
CESC
0.0014
low
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000187837
HIST1H1C
ESCA
Del
1.139697
0.109442
0.381779
0.260870
ENSG00000187837
HIST1H1C
BLCA
Amp
3.087502
0.241656
0.573650
0.294118
Copyright © 2023, Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.