Ensembl ID ENSG00000187837 Gene ID 3006 Accession 4716
Gene Symbol H1-2 Alias H1C;H1.2;H1F2;H1s-1;HIST1H1C Full Name H1.2 linker histone, cluster member
Position 6 : 26055740 - 26056470 Length 731 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

ENSG00000187837 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000187837 HIST1H1C 2.46 1.12e-13 BLCA
ENSG00000187837 HIST1H1C 2.26 1.79e-52 BRCA
ENSG00000187837 HIST1H1C 1.47 6.29e-14 LUSC
ENSG00000187837 HIST1H1C 1.44 1.20e-11 LIHC
ENSG00000187837 HIST1H1C 2.49 9.90e-21 UCEC
ENSG00000187837 HIST1H1C 1.57 6.03e-20 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000187837 HIST1H1C testicular germ cell cancer 12543810
ENSG00000187837 HIST1H1C tumors 1269855
ENSG00000187837 HIST1H1C breast cancer 16839218
ENSG00000187837 HIST1H1C testicular germ cell tumor 17223197
ENSG00000187837 HIST1H1C germ cell tumor 17328536
ENSG00000187837 HIST1H1C tumour 17537454
ENSG00000187837 HIST1H1C tumor 18852131
ENSG00000187837 HIST1H1C germ cell tumour 22071088
ENSG00000187837 HIST1H1C tumor 22749394
ENSG00000187837 HIST1H1C tumors 23060558
ENSG00000187837 HIST1H1C tumor 23112873
ENSG00000187837 HIST1H1C breast cancer 23151675
ENSG00000187837 HIST1H1C germ cell tumor 24215546
ENSG00000187837 HIST1H1C DLBCL 26473533
ENSG00000187837 HIST1H1C tumors 2691957
ENSG00000187837 HIST1H1C tumor 27765905
ENSG00000187837 HIST1H1C TGCT 28081228
ENSG00000187837 HIST1H1C prostate cancer 28832499
ENSG00000187837 HIST1H1C tumor 29029420
ENSG00000187837 HIST1H1C breast cancer 29050075
ENSG00000187837 HIST1H1C tumors 2964753
ENSG00000187837 HIST1H1C breast cancer 29915250
ENSG00000187837 HIST1H1C breast cancer 29946439
ENSG00000187837 HIST1H1C tumor 29963023
ENSG00000187837 HIST1H1C tumor 30718359
ENSG00000187837 HIST1H1C Cancer 30833417
ENSG00000187837 HIST1H1C AML 31577790
ENSG00000187837 HIST1H1C tumor 8033621
ENSG00000187837 HIST1H1C germ-cell cancer 8609154
ENSG00000187837 HIST1H1C tumor 9159349
ENSG00000187837 HIST1H1C tumour 9750020
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000187837 HIST1H1C MESO 0.00032 low
ENSG00000187837 HIST1H1C UVM 0.0053 low
ENSG00000187837 HIST1H1C UCEC 0.033 low
ENSG00000187837 HIST1H1C ACC 0.00037 high
ENSG00000187837 HIST1H1C READ 0.024 high
ENSG00000187837 HIST1H1C KIRP 0.033 high
ENSG00000187837 HIST1H1C KICH 0.027 low
ENSG00000187837 HIST1H1C PCPG 0.0063 low
ENSG00000187837 HIST1H1C THYM 0.0015 low
ENSG00000187837 HIST1H1C BRCA 0.046 low
ENSG00000187837 HIST1H1C COAD 0.012 high
ENSG00000187837 HIST1H1C UCS 0.0015 high
ENSG00000187837 HIST1H1C OV 0.0084 low
ENSG00000187837 HIST1H1C DLBC 0.00034 low
ENSG00000187837 HIST1H1C KIRC 0.035 high
ENSG00000187837 HIST1H1C BLCA 0.00026 low
ENSG00000187837 HIST1H1C LAML 0.01 high
ENSG00000187837 HIST1H1C SKCM 0.026 high
ENSG00000187837 HIST1H1C CESC 0.0014 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000187837 HIST1H1C ESCA Del 1.139697 0.109442 0.381779 0.260870
ENSG00000187837 HIST1H1C BLCA Amp 3.087502 0.241656 0.573650 0.294118