Ensembl ID ENSG00000186871 Gene ID 54821 Accession 20794
Gene Symbol ERCC6L Alias PICH;RAD26L Full Name ERCC excision repair 6 like, spindle assembly checkpoint helicase
Position X : 72204657 - 72239027 Length 34371 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF2) family of proteins, and contains a SNF2-like ATPase domain and a PICH family domain. One distinguishing feature of this SWI/SNF protein family member is that during interphase, the protein is excluded from the nucleus, and only associates with chromatin after the nuclear envelope has broken down. This protein is a DNA translocase that is thought to bind double-stranded DNA that is exposed to stretching forces, such as those exerted by the mitotic spindle. This protein associates with ribosomal DNA and ultra-fine DNA bridges (UFBs), fine structures that connect sister chromatids during anaphase at some sites such as fragile sites, telomeres and centromeres. This gene is required for the faithful segregation of sister chromatids during mitosis, and the ATPase activity of this protein required for the resolution of UFBs before cytokinesis. [provided by RefSeq, May 2017]

ENSG00000186871 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000186871 1.79 1.30e-35 KIRC
ENSG00000186871 1.18 9.67e-22 HNSC
ENSG00000186871 1.96 4.94e-16 BLCA
ENSG00000186871 2.85 1.50e-161 BRCA
ENSG00000186871 1.75 2.23e-44 COAD
ENSG00000186871 2.01 4.56e-11 KICH
ENSG00000186871 3.99 9.31e-197 LUSC
ENSG00000186871 1.15 1.56e-15 PRAD
ENSG00000186871 3.82 5.72e-17 GBM
ENSG00000186871 1.99 7.48e-18 KIRP
ENSG00000186871 3.19 2.91e-55 LIHC
ENSG00000186871 1.68 1.09e-22 STAD
ENSG00000186871 3.17 1.00e-81 UCEC
ENSG00000186871 1.79 2.60e-11 ESCA
ENSG00000186871 2.97 3.02e-14 CHOL
ENSG00000186871 5.01 1.17e-22 CESC
ENSG00000186871 3.29 1.36e-100 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000186871 kidney cancers 28178669
ENSG00000186871 ovarian epithelial tumors 29552194
ENSG00000186871 breast cancer 30066865
ENSG00000186871 cancer 30232008
ENSG00000186871 tumor 30459398
ENSG00000186871 tumors 31160555
ENSG00000186871 colorectal cancer 31289493
ENSG00000186871 breast cancer 31506496
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000186871 SARC 0.0061 high
ENSG00000186871 STAD 0.0039 low
ENSG00000186871 UVM 0.00053 high
ENSG00000186871 PAAD 0.00011 high
ENSG00000186871 UCEC 0.0044 high
ENSG00000186871 LUSC 0.031 low
ENSG00000186871 READ 0.0043 low
ENSG00000186871 LUAD 0.002 high
ENSG00000186871 PCPG 0.00045 high
ENSG00000186871 THYM 0.006 low
ENSG00000186871 BRCA 0.00017 high
ENSG00000186871 ESCA 0.034 high
ENSG00000186871 OV 0.0047 high
ENSG00000186871 PRAD 0.04 high
ENSG00000186871 SKCM 0.03 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency