Ensembl ID ENSG00000185624 Gene ID 5034 Accession 8548
Gene Symbol P4HB Alias DSI;GIT;PDI;PHDB;PDIA1;PO4DB;PO4HB;PROHB;CLCRP1;ERBA2L;P4Hbeta Full Name prolyl 4-hydroxylase subunit beta
Position 17 : 81843159 - 81860856 Length 17698 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]

ENSG00000185624 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000185624 P4HB 1.40 7.58e-57 KIRC
ENSG00000185624 P4HB 0.89 5.12e-12 BLCA
ENSG00000185624 P4HB 0.99 1.74e-44 BRCA
ENSG00000185624 P4HB 0.93 2.01e-27 LUSC
ENSG00000185624 P4HB 0.66 1.09e-15 PRAD
ENSG00000185624 P4HB 1.10 7.57e-28 KIRP
ENSG00000185624 P4HB 1.47 4.89e-40 UCEC
ENSG00000185624 P4HB 1.09 6.56e-37 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000185624 P4HB tumors 10352256
ENSG00000185624 P4HB prostate tumor 11762196
ENSG00000185624 P4HB tumour 12922171
ENSG00000185624 P4HB tumor 12963716
ENSG00000185624 P4HB breast tumor 15935701
ENSG00000185624 P4HB breast tumors 16048908
ENSG00000185624 P4HB tumor 17047051
ENSG00000185624 P4HB breast tumors 17996735
ENSG00000185624 P4HB cancer 18598068
ENSG00000185624 P4HB breast cancer 18621069
ENSG00000185624 P4HB breast cancer 18840527
ENSG00000185624 P4HB tumor 19008459
ENSG00000185624 P4HB lung cancer 19412661
ENSG00000185624 P4HB Prostate Cancer 19826136
ENSG00000185624 P4HB breast cancer 20064251
ENSG00000185624 P4HB colorectal cancer 20408130
ENSG00000185624 P4HB prostate cancer 20423148
ENSG00000185624 P4HB cancer 20625410
ENSG00000185624 P4HB cancer 21305254
ENSG00000185624 P4HB tumors 21503584
ENSG00000185624 P4HB tumor 21617224
ENSG00000185624 P4HB cancer 21682924
ENSG00000185624 P4HB cancer 21845100
ENSG00000185624 P4HB tumour 22013897
ENSG00000185624 P4HB cancer 22025610
ENSG00000185624 P4HB cancer 22073283
ENSG00000185624 P4HB cancer 22142258
ENSG00000185624 P4HB malignant brain tumor 22192797
ENSG00000185624 P4HB cancers 22262715
ENSG00000185624 P4HB tumor 22350012
ENSG00000185624 P4HB breast cancer 22393307
ENSG00000185624 P4HB breast cancer 22654912
ENSG00000185624 P4HB cancer 22715587
ENSG00000185624 P4HB tumor 22750028
ENSG00000185624 P4HB breast cancer 22819674
ENSG00000185624 P4HB tumor 22848702
ENSG00000185624 P4HB ovarian cancer 22988091
ENSG00000185624 P4HB pituitary tumor 23148211
ENSG00000185624 P4HB brain tumor 23192002
ENSG00000185624 P4HB cancer 23376309
ENSG00000185624 P4HB cancer 23400947
ENSG00000185624 P4HB GBM 23444257
ENSG00000185624 P4HB breast cancer 23635006
ENSG00000185624 P4HB cancer 23691448
ENSG00000185624 P4HB tumor 23762860
ENSG00000185624 P4HB tumor 24039668
ENSG00000185624 P4HB cancer 24070012
ENSG00000185624 P4HB tumour 24099319
ENSG00000185624 P4HB cancer 24184531
ENSG00000185624 P4HB liver tumors 24198826
ENSG00000185624 P4HB ovarian cancer 24202339
ENSG00000185624 P4HB lung cancer 24382781
ENSG00000185624 P4HB cancer 24464223
ENSG00000185624 P4HB cancer 24718594
ENSG00000185624 P4HB cancer 24768923
ENSG00000185624 P4HB Lung cancer 24911456
ENSG00000185624 P4HB GBM 24922660
ENSG00000185624 P4HB cancer 24934525
ENSG00000185624 P4HB tumor 25035848
ENSG00000185624 P4HB pancreas cancers 25186196
ENSG00000185624 P4HB tumor 25228833
ENSG00000185624 P4HB cancer 25256790
ENSG00000185624 P4HB neuronal tumor 25279252
ENSG00000185624 P4HB Breast cancer 25351600
ENSG00000185624 P4HB tumor 25386408
ENSG00000185624 P4HB cancer 25418581
ENSG00000185624 P4HB triple-negative breast cancer 25593085
ENSG00000185624 P4HB tumor 25610811
ENSG00000185624 P4HB tumour 25663939
ENSG00000185624 P4HB ovarian cancer 25688334
ENSG00000185624 P4HB lung cancer 25881463
ENSG00000185624 P4HB cancer 25912252
ENSG00000185624 P4HB cancers 25940440
ENSG00000185624 P4HB cancer 26052512
ENSG00000185624 P4HB cancer 26079208
ENSG00000185624 P4HB cancer 26176704
ENSG00000185624 P4HB tumor 26334999
ENSG00000185624 P4HB tumor 26351857
ENSG00000185624 P4HB ovarian cancer 26364260
ENSG00000185624 P4HB cancers 26445321
ENSG00000185624 P4HB tumor 26452217
ENSG00000185624 P4HB cancer 26511099
ENSG00000185624 P4HB cancer 26529064
ENSG00000185624 P4HB cancer 26808530
ENSG00000185624 P4HB tumor 26840563
ENSG00000185624 P4HB tumor 26962415
ENSG00000185624 P4HB tumor 27061029
ENSG00000185624 P4HB cancer 27080849
ENSG00000185624 P4HB breast cancer 27161215
ENSG00000185624 P4HB cancer 27197150
ENSG00000185624 P4HB cancer 27222589
ENSG00000185624 P4HB tumors 27308392
ENSG00000185624 P4HB tumour 27573496
ENSG00000185624 P4HB cancer 27885848
ENSG00000185624 P4HB Cancer 27889881
ENSG00000185624 P4HB tumor 28052026
ENSG00000185624 P4HB cancer 28112374
ENSG00000185624 P4HB cancer 28154250
ENSG00000185624 P4HB tumor 28160557
ENSG00000185624 P4HB breast cancer 28174679
ENSG00000185624 P4HB cancer 28417928
ENSG00000185624 P4HB prostate tumors 28439080
ENSG00000185624 P4HB cancer 28491820
ENSG00000185624 P4HB cancer 28534513
ENSG00000185624 P4HB cancer 28542133
ENSG00000185624 P4HB cancer 28613814
ENSG00000185624 P4HB cancer 28648146
ENSG00000185624 P4HB cancer 28650993
ENSG00000185624 P4HB cancer 28796255
ENSG00000185624 P4HB GBM 28846078
ENSG00000185624 P4HB tumor 28850778
ENSG00000185624 P4HB ovarian cancer 28857608
ENSG00000185624 P4HB cancer 29016698
ENSG00000185624 P4HB tumor 29069756
ENSG00000185624 P4HB tumor 29112124
ENSG00000185624 P4HB cancers 29139271
ENSG00000185624 P4HB tumor 29207176
ENSG00000185624 P4HB brain cancer 29235250
ENSG00000185624 P4HB cancers 29262583
ENSG00000185624 P4HB cancer 29316394
ENSG00000185624 P4HB cancer 29410027
ENSG00000185624 P4HB tumor 29692614
ENSG00000185624 P4HB cancer 29703471
ENSG00000185624 P4HB cancer 29707841
ENSG00000185624 P4HB Tumor 29796176
ENSG00000185624 P4HB gastric cancer 29904245
ENSG00000185624 P4HB cancer 30159384
ENSG00000185624 P4HB cancer 30188928
ENSG00000185624 P4HB tumor 30200125
ENSG00000185624 P4HB cancer 30289464
ENSG00000185624 P4HB tumor 30301907
ENSG00000185624 P4HB cancers 30344729
ENSG00000185624 P4HB colon cancer 30431122
ENSG00000185624 P4HB tumors 30458886
ENSG00000185624 P4HB cancer 30591932
ENSG00000185624 P4HB AMLs 30602683
ENSG00000185624 P4HB tumors 30620686
ENSG00000185624 P4HB cancer 30647455
ENSG00000185624 P4HB cancer 30652973
ENSG00000185624 P4HB cancer 30713500
ENSG00000185624 P4HB gastric cancer 30720117
ENSG00000185624 P4HB cancers 30754624
ENSG00000185624 P4HB cancer 30760703
ENSG00000185624 P4HB cancers 30826359
ENSG00000185624 P4HB cancer 30914420
ENSG00000185624 P4HB tumor 30996048
ENSG00000185624 P4HB thyroid cancer 31019533
ENSG00000185624 P4HB tumors 31029032
ENSG00000185624 P4HB lung cancer 31118562
ENSG00000185624 P4HB tumor 31149044
ENSG00000185624 P4HB cancer 31244948
ENSG00000185624 P4HB cancer 31310131
ENSG00000185624 P4HB cancers 31436131
ENSG00000185624 P4HB cancer 31459000
ENSG00000185624 P4HB tumor 31466436
ENSG00000185624 P4HB Gastric Cancer 31467922
ENSG00000185624 P4HB breast cancer 31497343
ENSG00000185624 P4HB cancer 31509261
ENSG00000185624 P4HB cancers 31526829
ENSG00000185624 P4HB cancers 31614132
ENSG00000185624 P4HB tumor 31632014
ENSG00000185624 P4HB tumor 31640086
ENSG00000185624 P4HB brain tumors 31674265
ENSG00000185624 P4HB Tumors 31779147
ENSG00000185624 P4HB cancer 31787362
ENSG00000185624 P4HB tumor 31794946
ENSG00000185624 P4HB tumor 5729488
ENSG00000185624 P4HB breast tumor 7750794
ENSG00000185624 P4HB liver cancer 7966454
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000185624 P4HB SARC 0.0074 high
ENSG00000185624 P4HB CHOL 0.049 high
ENSG00000185624 P4HB UCEC 0.0038 low
ENSG00000185624 P4HB THCA 0.0063 high
ENSG00000185624 P4HB ACC 0.00096 high
ENSG00000185624 P4HB HNSC 0.012 high
ENSG00000185624 P4HB KICH 0.00061 high
ENSG00000185624 P4HB LUAD 0.02 high
ENSG00000185624 P4HB BRCA 0.0015 low
ENSG00000185624 P4HB COAD 0.02 low
ENSG00000185624 P4HB OV 0.011 low
ENSG00000185624 P4HB DLBC 0.013 low
ENSG00000185624 P4HB TGCT 0.0019 high
ENSG00000185624 P4HB BLCA 0.00043 high
ENSG00000185624 P4HB LAML 0.0027 low
ENSG00000185624 P4HB GBM 0.0044 high
ENSG00000185624 P4HB CESC 0.0026 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000185624 P4HB LGG Amp 2.303541 0.067370 0.491950 0.091618
ENSG00000185624 P4HB CESC Del 1.839225 0.088447 0.461774 0.149153
ENSG00000185624 P4HB LIHC Amp 11.915172 0.315412 0.711330 0.381081
ENSG00000185624 P4HB BLCA Amp 2.265064 0.217753 0.469934 0.470588
ENSG00000185624 P4HB BRCA Amp 18.323414 0.336335 0.612094 0.357407
ENSG00000185624 P4HB UCEC Amp 6.128691 0.198298 0.593660 0.185529
ENSG00000185624 P4HB OV Amp 3.344093 0.412080 0.564364 0.360967