Ensembl ID ENSG00000185624 Gene ID 5034 Accession 8548
Gene Symbol P4HB Alias DSI;GIT;PDI;PHDB;PDIA1;PO4DB;PO4HB;PROHB;CLCRP1;ERBA2L;P4Hbeta Full Name prolyl 4-hydroxylase subunit beta
Position 17 : 81843159 - 81860856 Length 17698 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]

ENSG00000185624 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000185624 1.40 7.58e-57 KIRC
ENSG00000185624 0.89 5.12e-12 BLCA
ENSG00000185624 0.99 1.74e-44 BRCA
ENSG00000185624 0.93 2.01e-27 LUSC
ENSG00000185624 0.66 1.09e-15 PRAD
ENSG00000185624 1.10 7.57e-28 KIRP
ENSG00000185624 1.47 4.89e-40 UCEC
ENSG00000185624 1.09 6.56e-37 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000185624 tumors 10352256
ENSG00000185624 prostate tumor 11762196
ENSG00000185624 tumour 12922171
ENSG00000185624 tumor 12963716
ENSG00000185624 breast tumor 15935701
ENSG00000185624 breast tumors 16048908
ENSG00000185624 tumor 17047051
ENSG00000185624 breast tumors 17996735
ENSG00000185624 cancer 18598068
ENSG00000185624 breast cancer 18621069
ENSG00000185624 breast cancer 18840527
ENSG00000185624 tumor 19008459
ENSG00000185624 lung cancer 19412661
ENSG00000185624 Prostate Cancer 19826136
ENSG00000185624 breast cancer 20064251
ENSG00000185624 colorectal cancer 20408130
ENSG00000185624 prostate cancer 20423148
ENSG00000185624 cancer 20625410
ENSG00000185624 cancer 21305254
ENSG00000185624 tumors 21503584
ENSG00000185624 tumor 21617224
ENSG00000185624 cancer 21682924
ENSG00000185624 cancer 21845100
ENSG00000185624 tumour 22013897
ENSG00000185624 cancer 22025610
ENSG00000185624 cancer 22073283
ENSG00000185624 cancer 22142258
ENSG00000185624 malignant brain tumor 22192797
ENSG00000185624 cancers 22262715
ENSG00000185624 tumor 22350012
ENSG00000185624 breast cancer 22393307
ENSG00000185624 breast cancer 22654912
ENSG00000185624 cancer 22715587
ENSG00000185624 tumor 22750028
ENSG00000185624 breast cancer 22819674
ENSG00000185624 tumor 22848702
ENSG00000185624 ovarian cancer 22988091
ENSG00000185624 pituitary tumor 23148211
ENSG00000185624 brain tumor 23192002
ENSG00000185624 cancer 23376309
ENSG00000185624 cancer 23400947
ENSG00000185624 GBM 23444257
ENSG00000185624 breast cancer 23635006
ENSG00000185624 cancer 23691448
ENSG00000185624 tumor 23762860
ENSG00000185624 tumor 24039668
ENSG00000185624 cancer 24070012
ENSG00000185624 tumour 24099319
ENSG00000185624 cancer 24184531
ENSG00000185624 liver tumors 24198826
ENSG00000185624 ovarian cancer 24202339
ENSG00000185624 lung cancer 24382781
ENSG00000185624 cancer 24464223
ENSG00000185624 cancer 24718594
ENSG00000185624 cancer 24768923
ENSG00000185624 Lung cancer 24911456
ENSG00000185624 GBM 24922660
ENSG00000185624 cancer 24934525
ENSG00000185624 tumor 25035848
ENSG00000185624 pancreas cancers 25186196
ENSG00000185624 tumor 25228833
ENSG00000185624 cancer 25256790
ENSG00000185624 neuronal tumor 25279252
ENSG00000185624 Breast cancer 25351600
ENSG00000185624 tumor 25386408
ENSG00000185624 cancer 25418581
ENSG00000185624 triple-negative breast cancer 25593085
ENSG00000185624 tumor 25610811
ENSG00000185624 tumour 25663939
ENSG00000185624 ovarian cancer 25688334
ENSG00000185624 lung cancer 25881463
ENSG00000185624 cancer 25912252
ENSG00000185624 cancers 25940440
ENSG00000185624 cancer 26052512
ENSG00000185624 cancer 26079208
ENSG00000185624 cancer 26176704
ENSG00000185624 tumor 26334999
ENSG00000185624 tumor 26351857
ENSG00000185624 ovarian cancer 26364260
ENSG00000185624 cancers 26445321
ENSG00000185624 tumor 26452217
ENSG00000185624 cancer 26511099
ENSG00000185624 cancer 26529064
ENSG00000185624 cancer 26808530
ENSG00000185624 tumor 26840563
ENSG00000185624 tumor 26962415
ENSG00000185624 tumor 27061029
ENSG00000185624 cancer 27080849
ENSG00000185624 breast cancer 27161215
ENSG00000185624 cancer 27197150
ENSG00000185624 cancer 27222589
ENSG00000185624 tumors 27308392
ENSG00000185624 tumour 27573496
ENSG00000185624 cancer 27885848
ENSG00000185624 Cancer 27889881
ENSG00000185624 tumor 28052026
ENSG00000185624 cancer 28112374
ENSG00000185624 cancer 28154250
ENSG00000185624 tumor 28160557
ENSG00000185624 breast cancer 28174679
ENSG00000185624 cancer 28417928
ENSG00000185624 prostate tumors 28439080
ENSG00000185624 cancer 28491820
ENSG00000185624 cancer 28534513
ENSG00000185624 cancer 28542133
ENSG00000185624 cancer 28613814
ENSG00000185624 cancer 28648146
ENSG00000185624 cancer 28650993
ENSG00000185624 cancer 28796255
ENSG00000185624 GBM 28846078
ENSG00000185624 tumor 28850778
ENSG00000185624 ovarian cancer 28857608
ENSG00000185624 cancer 29016698
ENSG00000185624 tumor 29069756
ENSG00000185624 tumor 29112124
ENSG00000185624 cancers 29139271
ENSG00000185624 tumor 29207176
ENSG00000185624 brain cancer 29235250
ENSG00000185624 cancers 29262583
ENSG00000185624 cancer 29316394
ENSG00000185624 cancer 29410027
ENSG00000185624 tumor 29692614
ENSG00000185624 cancer 29703471
ENSG00000185624 cancer 29707841
ENSG00000185624 Tumor 29796176
ENSG00000185624 gastric cancer 29904245
ENSG00000185624 cancer 30159384
ENSG00000185624 cancer 30188928
ENSG00000185624 tumor 30200125
ENSG00000185624 cancer 30289464
ENSG00000185624 tumor 30301907
ENSG00000185624 cancers 30344729
ENSG00000185624 colon cancer 30431122
ENSG00000185624 tumors 30458886
ENSG00000185624 cancer 30591932
ENSG00000185624 AMLs 30602683
ENSG00000185624 tumors 30620686
ENSG00000185624 cancer 30647455
ENSG00000185624 cancer 30652973
ENSG00000185624 cancer 30713500
ENSG00000185624 gastric cancer 30720117
ENSG00000185624 cancers 30754624
ENSG00000185624 cancer 30760703
ENSG00000185624 cancers 30826359
ENSG00000185624 cancer 30914420
ENSG00000185624 tumor 30996048
ENSG00000185624 thyroid cancer 31019533
ENSG00000185624 tumors 31029032
ENSG00000185624 lung cancer 31118562
ENSG00000185624 tumor 31149044
ENSG00000185624 cancer 31244948
ENSG00000185624 cancer 31310131
ENSG00000185624 cancers 31436131
ENSG00000185624 cancer 31459000
ENSG00000185624 tumor 31466436
ENSG00000185624 Gastric Cancer 31467922
ENSG00000185624 breast cancer 31497343
ENSG00000185624 cancer 31509261
ENSG00000185624 cancers 31526829
ENSG00000185624 cancers 31614132
ENSG00000185624 tumor 31632014
ENSG00000185624 tumor 31640086
ENSG00000185624 brain tumors 31674265
ENSG00000185624 Tumors 31779147
ENSG00000185624 cancer 31787362
ENSG00000185624 tumor 31794946
ENSG00000185624 tumor 5729488
ENSG00000185624 breast tumor 7750794
ENSG00000185624 liver cancer 7966454
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000185624 SARC 0.0074 high
ENSG00000185624 CHOL 0.049 high
ENSG00000185624 UCEC 0.0038 low
ENSG00000185624 THCA 0.0063 high
ENSG00000185624 ACC 0.00096 high
ENSG00000185624 HNSC 0.012 high
ENSG00000185624 KICH 0.00061 high
ENSG00000185624 LUAD 0.02 high
ENSG00000185624 BRCA 0.0015 low
ENSG00000185624 COAD 0.02 low
ENSG00000185624 OV 0.011 low
ENSG00000185624 DLBC 0.013 low
ENSG00000185624 TGCT 0.0019 high
ENSG00000185624 BLCA 0.00043 high
ENSG00000185624 LAML 0.0027 low
ENSG00000185624 GBM 0.0044 high
ENSG00000185624 CESC 0.0026 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000185624 LGG Amp 2.303541 0.067370 0.491950 0.091618
ENSG00000185624 CESC Del 1.839225 0.088447 0.461774 0.149153
ENSG00000185624 LIHC Amp 11.915172 0.315412 0.711330 0.381081
ENSG00000185624 BLCA Amp 2.265064 0.217753 0.469934 0.470588
ENSG00000185624 BRCA Amp 18.323414 0.336335 0.612094 0.357407
ENSG00000185624 UCEC Amp 6.128691 0.198298 0.593660 0.185529
ENSG00000185624 OV Amp 3.344093 0.412080 0.564364 0.360967