Ensembl ID ENSG00000185129 Gene ID 5813 Accession 9701
Gene Symbol PURA Alias PUR1;MRD31;NEDRIHF;PURALPHA;PUR-ALPHA Full Name purine rich element binding protein A
Position 5 : 140107777 - 140125619 Length 17843 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]

ENSG00000185129 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000185129 PURA -0.6 1.20e-25 BRCA
ENSG00000185129 PURA -0.8 4.83e-42 LUSC
ENSG00000185129 PURA -1.3 7.75e-12 GBM
ENSG00000185129 PURA -0.7 6.82e-11 KIRP
ENSG00000185129 PURA -0.9 1.60e-17 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000185129 PURA cancer 14580768
ENSG00000185129 PURA cancer 18927497
ENSG00000185129 PURA cancer 27748283
ENSG00000185129 PURA tumor 29502225
ENSG00000185129 PURA GBM 31358880
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000185129 PURA MESO 0.049 low
ENSG00000185129 PURA CHOL 0.017 low
ENSG00000185129 PURA UVM 0.0037 high
ENSG00000185129 PURA ACC 0.0077 low
ENSG00000185129 PURA LUAD 0.024 low
ENSG00000185129 PURA THYM 0.03 high
ENSG00000185129 PURA UCS 0.0056 high
ENSG00000185129 PURA GBM 0.047 low
ENSG00000185129 PURA CESC 0.0089 low
ENSG00000185129 PURA LIHC 0.039 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000185129 PURA LAML Del 6.887040 0.098062 0.800690 0.089005
ENSG00000185129 PURA LGG Del 1.085329 0.043264 0.391376 0.085770
ENSG00000185129 PURA ACC Amp 1.613162 0.375694 1.280781 0.677778
ENSG00000185129 PURA SKCM Del 6.243556 0.135700 0.498943 0.340599
ENSG00000185129 PURA KIRC Amp 51.061677 0.292110 0.543534 0.609848