Ensembl ID ENSG00000182481 Gene ID 3838 Accession 6395
Gene Symbol KPNA2 Alias QIP2;RCH1;IPOA1;PTAC58;SRP1alpha;SRP1-alpha Full Name karyopherin subunit alpha 2
Position 17 : 68035636 - 68046854 Length 11219 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

ENSG00000182481 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000182481 KPNA2 1.14 3.20e-35 HNSC
ENSG00000182481 KPNA2 1.48 4.54e-14 BLCA
ENSG00000182481 KPNA2 2.15 4.05e-112 BRCA
ENSG00000182481 KPNA2 1.23 3.22e-43 COAD
ENSG00000182481 KPNA2 2.52 4.43e-141 LUSC
ENSG00000182481 KPNA2 0.70 1.68e-12 PRAD
ENSG00000182481 KPNA2 1.41 3.73e-30 LIHC
ENSG00000182481 KPNA2 1.37 3.64e-23 STAD
ENSG00000182481 KPNA2 2.58 5.89e-76 UCEC
ENSG00000182481 KPNA2 1.65 4.15e-13 ESCA
ENSG00000182481 KPNA2 2.77 4.53e-18 CESC
ENSG00000182481 KPNA2 1.95 5.98e-53 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000182481 KPNA2 tumor 16188882
ENSG00000182481 KPNA2 pituitary tumor 16487489
ENSG00000182481 KPNA2 tumor 16818692
ENSG00000182481 KPNA2 tumor 17899179
ENSG00000182481 KPNA2 breast cancer 18561322
ENSG00000182481 KPNA2 tumor 20393006
ENSG00000182481 KPNA2 lung cancer 20658535
ENSG00000182481 KPNA2 epithelial ovarian cancer 20859152
ENSG00000182481 KPNA2 Breast-Cancer 21034433
ENSG00000182481 KPNA2 prostate cancer 21220479
ENSG00000182481 KPNA2 tumor 21909132
ENSG00000182481 KPNA2 nonsmall cell lung cancer 22843992
ENSG00000182481 KPNA2 tumors 22962582
ENSG00000182481 KPNA2 cancer 23268335
ENSG00000182481 KPNA2 tumor 23283818
ENSG00000182481 KPNA2 cancer 23536776
ENSG00000182481 KPNA2 tumor 23749771
ENSG00000182481 KPNA2 prostate cancers 23887301
ENSG00000182481 KPNA2 cancers 23907459
ENSG00000182481 KPNA2 non-small-cell lung cancer 24070213
ENSG00000182481 KPNA2 tumor 24098495
ENSG00000182481 KPNA2 prostate cancers 24510842
ENSG00000182481 KPNA2 breast cancer 24735615
ENSG00000182481 KPNA2 breast cancer 24747666
ENSG00000182481 KPNA2 cancer 24748173
ENSG00000182481 KPNA2 tumor 24757335
ENSG00000182481 KPNA2 endometrial cancers 24930886
ENSG00000182481 KPNA2 tumor 25031071
ENSG00000182481 KPNA2 tumor 25060425
ENSG00000182481 KPNA2 tumors 25109899
ENSG00000182481 KPNA2 cancer 25728791
ENSG00000182481 KPNA2 tumor 25956057
ENSG00000182481 KPNA2 tumour 25989275
ENSG00000182481 KPNA2 cancers 26204489
ENSG00000182481 KPNA2 colon cancer 26626145
ENSG00000182481 KPNA2 colorectal cancer 26663089
ENSG00000182481 KPNA2 squamous cell cancer 26884852
ENSG00000182481 KPNA2 cancer 26887791
ENSG00000182481 KPNA2 cancer 27009856
ENSG00000182481 KPNA2 bladder cancer 27034531
ENSG00000182481 KPNA2 tumor 27078844
ENSG00000182481 KPNA2 colorectal tumor 27107455
ENSG00000182481 KPNA2 cancer 27121919
ENSG00000182481 KPNA2 cancer 27154959
ENSG00000182481 KPNA2 cancer 27338241
ENSG00000182481 KPNA2 bladder cancer 27611951
ENSG00000182481 KPNA2 cancer 27849024
ENSG00000182481 KPNA2 tumors 27974678
ENSG00000182481 KPNA2 cancer 28178675
ENSG00000182481 KPNA2 tumor 28422734
ENSG00000182481 KPNA2 tumors 28422979
ENSG00000182481 KPNA2 cancer 28454233
ENSG00000182481 KPNA2 cancer 28476582
ENSG00000182481 KPNA2 epithelial ovarian cancer 28651492
ENSG00000182481 KPNA2 cancers 28875407
ENSG00000182481 KPNA2 liver cancer 29100313
ENSG00000182481 KPNA2 epithelial ovarian cancer 29290781
ENSG00000182481 KPNA2 tumor 29435009
ENSG00000182481 KPNA2 cancer 29580221
ENSG00000182481 KPNA2 breast cancer 29699511
ENSG00000182481 KPNA2 cancer 29781035
ENSG00000182481 KPNA2 tumor 30115078
ENSG00000182481 KPNA2 gallbladder cancer 30254209
ENSG00000182481 KPNA2 GBM 30323892
ENSG00000182481 KPNA2 tumors 30397353
ENSG00000182481 KPNA2 tumors 30448104
ENSG00000182481 KPNA2 breast cancer 30531833
ENSG00000182481 KPNA2 lung cancer 30542454
ENSG00000182481 KPNA2 invasive breast cancer 30588106
ENSG00000182481 KPNA2 GBM 30671385
ENSG00000182481 KPNA2 breast cancer 30732163
ENSG00000182481 KPNA2 cancer 30883648
ENSG00000182481 KPNA2 cancer 31046781
ENSG00000182481 KPNA2 colorectal cancer 31127650
ENSG00000182481 KPNA2 cancers 31179341
ENSG00000182481 KPNA2 cancer 31212646
ENSG00000182481 KPNA2 cancer 31240215
ENSG00000182481 KPNA2 colorectal cancer 31581454
ENSG00000182481 KPNA2 cancer 31612029
ENSG00000182481 KPNA2 tumor 31695414
ENSG00000182481 KPNA2 tumor 31695969
ENSG00000182481 KPNA2 liver cancer 31783876
ENSG00000182481 KPNA2 Prostate Cancers 31809312
ENSG00000182481 KPNA2 cancer 31812670
ENSG00000182481 KPNA2 Lung Cancer 31920336
ENSG00000182481 KPNA2 tumor 7790349
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000182481 KPNA2 SARC 0.004 high
ENSG00000182481 KPNA2 STAD 0.034 low
ENSG00000182481 KPNA2 PAAD 0.0054 high
ENSG00000182481 KPNA2 UCEC 0.011 high
ENSG00000182481 KPNA2 HNSC 0.0035 high
ENSG00000182481 KPNA2 READ 0.009 low
ENSG00000182481 KPNA2 KICH 0.00014 high
ENSG00000182481 KPNA2 LUAD 0.00014 high
ENSG00000182481 KPNA2 PCPG 0.0025 low
ENSG00000182481 KPNA2 THYM 0.0056 low
ENSG00000182481 KPNA2 COAD 0.0036 low
ENSG00000182481 KPNA2 DLBC 0.001 low
ENSG00000182481 KPNA2 BLCA 0.00028 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000182481 KPNA2 LUSC Amp 1.331639 0.215527 0.443381 0.467066
ENSG00000182481 KPNA2 LUAD Amp 2.497459 0.159764 0.410414 0.486434
ENSG00000182481 KPNA2 LGG Amp 2.267891 0.066740 0.586028 0.074074
ENSG00000182481 KPNA2 CESC Amp 1.277813 0.151512 0.557218 0.244068
ENSG00000182481 KPNA2 COAD Amp 1.180150 0.077565 0.518238 0.230599
ENSG00000182481 KPNA2 UCS Amp 0.699772 0.492451 0.775503 0.500000
ENSG00000182481 KPNA2 PAAD Del 3.748419 0.099439 0.369696 0.217391
ENSG00000182481 KPNA2 SKCM Amp 5.033719 0.243536 0.562177 0.335150
ENSG00000182481 KPNA2 LIHC Amp 5.255398 0.211620 0.645818 0.362162
ENSG00000182481 KPNA2 BLCA Amp 1.682818 0.199631 0.470265 0.468137
ENSG00000182481 KPNA2 BRCA Amp 49.463036 0.545487 0.814525 0.404630
ENSG00000182481 KPNA2 UCEC Amp 2.604956 0.144212 0.609320 0.150278
ENSG00000182481 KPNA2 UVM Amp 0.739547 0.167801 0.821270 0.162500