Ensembl ID ENSG00000181026 Gene ID 64782 Accession 25722
Gene Symbol AEN Alias ISG20L1;pp12744 Full Name apoptosis enhancing nuclease
Position 15 : 88621340 - 88632281 Length 10942 bases Strand Plus strand
Status Confidence Main interacting RNAsdiverseRBP type Canonical_RBPs
Summary Enables exonuclease activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and response to ionizing radiation. Located in nuclear membrane; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ENSG00000181026 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000181026 AEN 1.38 1.60e-86 KIRC
ENSG00000181026 AEN 0.42 4.61e-13 BRCA
ENSG00000181026 AEN 1.37 5.36e-44 COAD
ENSG00000181026 AEN 1.62 5.08e-21 KICH
ENSG00000181026 AEN 1.22 1.73e-44 KIRP
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000181026 AEN tumour 19382019
ENSG00000181026 AEN cancer 20429933
ENSG00000181026 AEN tumor 24748736
ENSG00000181026 AEN breast cancer 26921029
ENSG00000181026 AEN cancer 27158268
ENSG00000181026 AEN tumour 29463228
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000181026 AEN MESO 0.0016 high
ENSG00000181026 AEN STAD 0.0051 low
ENSG00000181026 AEN UVM 0.00057 high
ENSG00000181026 AEN THCA 0.016 high
ENSG00000181026 AEN HNSC 0.041 high
ENSG00000181026 AEN KIRP 0.0042 low
ENSG00000181026 AEN LUAD 0.049 high
ENSG00000181026 AEN THYM 0.0013 low
ENSG00000181026 AEN COAD 0.012 high
ENSG00000181026 AEN UCS 0.024 high
ENSG00000181026 AEN OV 0.023 low
ENSG00000181026 AEN KIRC 0.0023 low
ENSG00000181026 AEN PRAD 0.035 high
ENSG00000181026 AEN BLCA 0.0047 high
ENSG00000181026 AEN GBM 0.033 high
ENSG00000181026 AEN SKCM 0.002 high
ENSG00000181026 AEN CESC 0.035 low
ENSG00000181026 AEN LIHC 0.033 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000181026 AEN CESC Amp 1.595064 0.163303 0.545523 0.250847
ENSG00000181026 AEN SKCM Amp 3.549693 0.204249 0.542140 0.318801
ENSG00000181026 AEN BRCA Amp 1.269855 0.157156 0.565901 0.162963
ENSG00000181026 AEN STAD Amp 4.209120 0.221085 0.566590 0.213152