Ensembl ID ENSG00000180370 Gene ID 5062 Accession 8591
Gene Symbol PAK2 Alias KNO2;PAK65;PAKgamma Full Name p21 (RAC1) activated kinase 2
Position 3 : 196739857 - 196832647 Length 92791 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]

ENSG00000180370 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000180370 PAK2 0.67 7.23e-16 HNSC
ENSG00000180370 PAK2 0.76 3.82e-20 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000180370 PAK2 cancer 15072767
ENSG00000180370 PAK2 prostate cancer 15908432
ENSG00000180370 PAK2 tumor 16718496
ENSG00000180370 PAK2 breast cancer 19242610
ENSG00000180370 PAK2 tumor 19289088
ENSG00000180370 PAK2 cancer 21423607
ENSG00000180370 PAK2 cancer 21499899
ENSG00000180370 PAK2 tumor 22362252
ENSG00000180370 PAK2 cancer 22364609
ENSG00000180370 PAK2 tumor 22863318
ENSG00000180370 PAK2 breast cancer 22886747
ENSG00000180370 PAK2 cervical cancer 23052694
ENSG00000180370 PAK2 tumor 23425030
ENSG00000180370 PAK2 breast cancer 23580553
ENSG00000180370 PAK2 tumors 23960073
ENSG00000180370 PAK2 ovarian cancer 24434518
ENSG00000180370 PAK2 gastric cancer 24621074
ENSG00000180370 PAK2 HNSCC 24634274
ENSG00000180370 PAK2 breast cancer 24957886
ENSG00000180370 PAK2 ovarian cancer 25050916
ENSG00000180370 PAK2 tumor 25065596
ENSG00000180370 PAK2 breast cancer 25902869
ENSG00000180370 PAK2 tumor 25985904
ENSG00000180370 PAK2 cancers 27648129
ENSG00000180370 PAK2 Tumour 28432311
ENSG00000180370 PAK2 DLBCL 28707321
ENSG00000180370 PAK2 luminal breast cancer 29353882
ENSG00000180370 PAK2 tumor 29362401
ENSG00000180370 PAK2 cancers 29510700
ENSG00000180370 PAK2 tumors 29596304
ENSG00000180370 PAK2 tumors 29714078
ENSG00000180370 PAK2 ER+ breast cancer 29987050
ENSG00000180370 PAK2 cancer 30068946
ENSG00000180370 PAK2 breast cancer 30243723
ENSG00000180370 PAK2 tumor 30361447
ENSG00000180370 PAK2 pancreatic cancer 30520694
ENSG00000180370 PAK2 breast cancer 30754684
ENSG00000180370 PAK2 tumor 30930982
ENSG00000180370 PAK2 breast cancer 30964173
ENSG00000180370 PAK2 cancer 30988666
ENSG00000180370 PAK2 cancer 31051214
ENSG00000180370 PAK2 cancers 31310629
ENSG00000180370 PAK2 tumor 31391918
ENSG00000180370 PAK2 non-small cell lung cancer 31587474
ENSG00000180370 PAK2 cancer 31828845
ENSG00000180370 PAK2 colorectal cancer 31902050
ENSG00000180370 PAK2 tumor 31969394
ENSG00000180370 PAK2 breast cancer 31987914
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000180370 PAK2 MESO 0.00029 high
ENSG00000180370 PAK2 STAD 0.048 high
ENSG00000180370 PAK2 CHOL 0.014 low
ENSG00000180370 PAK2 UVM 0.0079 low
ENSG00000180370 PAK2 PAAD 0.00038 high
ENSG00000180370 PAK2 UCEC 0.019 high
ENSG00000180370 PAK2 THCA 0.013 high
ENSG00000180370 PAK2 ACC 0.035 high
ENSG00000180370 PAK2 LGG 0.0014 high
ENSG00000180370 PAK2 READ 0.021 high
ENSG00000180370 PAK2 KICH 0.0042 high
ENSG00000180370 PAK2 LUAD 0.002 high
ENSG00000180370 PAK2 THYM 0.00053 low
ENSG00000180370 PAK2 BRCA 0.0034 high
ENSG00000180370 PAK2 OV 0.018 high
ENSG00000180370 PAK2 KIRC 0.0024 low
ENSG00000180370 PAK2 PRAD 0.00092 high
ENSG00000180370 PAK2 TGCT 0.01 high
ENSG00000180370 PAK2 GBM 0.042 low
ENSG00000180370 PAK2 SKCM 0.0012 low
ENSG00000180370 PAK2 LIHC 0.00042 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000180370 PAK2 LUAD Del 1.910623 0.066302 0.330840 0.263566
ENSG00000180370 PAK2 LGG Del 4.325299 0.070488 0.520490 0.093567
ENSG00000180370 PAK2 CESC Amp 27.921881 0.675335 1.073535 0.752542
ENSG00000180370 PAK2 SARC Del 0.809880 0.123852 0.494044 0.202335
ENSG00000180370 PAK2 GBM Amp 0.934333 0.071930 0.434429 0.138648
ENSG00000180370 PAK2 GBM Del 3.006199 0.076742 0.480420 0.100520
ENSG00000180370 PAK2 HNSC Amp 41.177978 0.615860 0.779481 0.716475
ENSG00000180370 PAK2 PCPG Del 3.076290 0.103587 0.635101 0.586420
ENSG00000180370 PAK2 TGCT Amp 0.658729 0.114148 0.427058 0.293333
ENSG00000180370 PAK2 DLBC Amp 2.314444 0.360896 0.811921 0.312500
ENSG00000180370 PAK2 STAD Amp 4.719108 0.231600 0.489955 0.340136
ENSG00000180370 PAK2 PRAD Del 0.751084 0.072617 0.456371 0.069106
ENSG00000180370 PAK2 KIRC Amp 1.802912 0.045776 0.389691 0.159091