Ensembl ID ENSG00000179750 Gene ID 9582 Accession 17352
Gene Symbol APOBEC3B Alias A3B;ARP4;ARCD3;PHRBNL;APOBEC1L;bK150C2.2;DJ742C19.2 Full Name apolipoprotein B mRNA editing enzyme catalytic subunit 3B
Position 22 : 38982347 - 38992804 Length 10458 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

ENSG00000179750 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000179750 0.99 1.45e-13 KIRC
ENSG00000179750 1.64 7.60e-17 HNSC
ENSG00000179750 2.58 1.42e-62 BRCA
ENSG00000179750 -1.7 6.23e-25 COAD
ENSG00000179750 3.44 1.80e-85 LUSC
ENSG00000179750 5.11 4.23e-20 GBM
ENSG00000179750 1.87 1.55e-13 LIHC
ENSG00000179750 2.85 3.21e-35 UCEC
ENSG00000179750 2.19 2.28e-27 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000179750 tumor 17847074
ENSG00000179750 liver cancer 18448976
ENSG00000179750 cancer 18636146
ENSG00000179750 tumors 22825724
ENSG00000179750 tumor 23150777
ENSG00000179750 cancers 23388464
ENSG00000179750 breast cancer 23389445
ENSG00000179750 breast cancer 23598277
ENSG00000179750 breast cancer 23599896
ENSG00000179750 breast cancer 23715497
ENSG00000179750 cancers 23852168
ENSG00000179750 cancer 24073723
ENSG00000179750 cancer 24705290
ENSG00000179750 breast cancer 24728294
ENSG00000179750 non-small-cell lung cancer 24748981
ENSG00000179750 cancers 24843013
ENSG00000179750 cancer 24843014
ENSG00000179750 cancers 24858917
ENSG00000179750 cancer 24910434
ENSG00000179750 cancers 25071824
ENSG00000179750 tumor 25085003
ENSG00000179750 tumor 25123150
ENSG00000179750 cancer 25176183
ENSG00000179750 breast cancer 25296601
ENSG00000179750 cancer 25298230
ENSG00000179750 Tumor 25401976
ENSG00000179750 pancreatic cancer 25502777
ENSG00000179750 Cancer 25538195
ENSG00000179750 cancer 25566802
ENSG00000179750 breast cancer 25730878
ENSG00000179750 tumor 25750306
ENSG00000179750 cervical cancer 25800874
ENSG00000179750 breast cancer 25807502
ENSG00000179750 breast cancer 25848704
ENSG00000179750 cancer 26051357
ENSG00000179750 cancers 26083936
ENSG00000179750 tumor 26091828
ENSG00000179750 breast cancer 26097867
ENSG00000179750 metastatic tumors 26159519
ENSG00000179750 gastric cancer 26191203
ENSG00000179750 cancer 26195824
ENSG00000179750 tumor 26221327
ENSG00000179750 cancers 26258849
ENSG00000179750 breast cancer 26320772
ENSG00000179750 cancers 26398702
ENSG00000179750 Breast Cancer 26411678
ENSG00000179750 cancer 26416889
ENSG00000179750 cancers 26420215
ENSG00000179750 breast cancers 26476745
ENSG00000179750 cancer 26544511
ENSG00000179750 breast cancers 26682542
ENSG00000179750 breast cancers 26691275
ENSG00000179750 cancers 26755635
ENSG00000179750 tumor 26760979
ENSG00000179750 cancer 26832400
ENSG00000179750 cancer 26880326
ENSG00000179750 cancer 26881778
ENSG00000179750 breast cancer 26920143
ENSG00000179750 invasive breast cancer 26926109
ENSG00000179750 ovarian tumors 26936395
ENSG00000179750 tumours 26965286
ENSG00000179750 cancers 27042257
ENSG00000179750 breast cancer 27044816
ENSG00000179750 breast cancers 27053248
ENSG00000179750 Lung Cancer 27076842
ENSG00000179750 cancer 27155849
ENSG00000179750 cancer 27163364
ENSG00000179750 cancers 27163633
ENSG00000179750 breast cancer 27233495
ENSG00000179750 cancers 27485054
ENSG00000179750 ovarian cancer 27527602
ENSG00000179750 Breast Cancer 27552096
ENSG00000179750 cancer 27577680
ENSG00000179750 breast cancer 27600231
ENSG00000179750 breast cancers 27634334
ENSG00000179750 bladder cancer 27643540
ENSG00000179750 tumours 27650891
ENSG00000179750 breast cancer 27716362
ENSG00000179750 tumor 27730215
ENSG00000179750 breast cancer 27747193
ENSG00000179750 cancer 27818121
ENSG00000179750 Breast Cancer 27977754
ENSG00000179750 cancer 27991903
ENSG00000179750 breast cancer 28062980
ENSG00000179750 cancers 28077648
ENSG00000179750 cancer 28100701
ENSG00000179750 cancer 28117753
ENSG00000179750 tumor 28141868
ENSG00000179750 cancer 28232385
ENSG00000179750 Cancers 28276478
ENSG00000179750 cancer 28334887
ENSG00000179750 cancer 28439266
ENSG00000179750 tumours 28535155
ENSG00000179750 cancers 28572915
ENSG00000179750 cancer 28575276
ENSG00000179750 cancer 28655787
ENSG00000179750 Cancer 28698210
ENSG00000179750 cancers 28825669
ENSG00000179750 cancer 28878238
ENSG00000179750 cancers 28952713
ENSG00000179750 tumour 28977491
ENSG00000179750 cancer 28981865
ENSG00000179750 ovarian cancer 29100317
ENSG00000179750 cervical cancer 29103025
ENSG00000179750 Breast cancer 29116104
ENSG00000179750 cancer 29153851
ENSG00000179750 cancer 29234087
ENSG00000179750 cancers 29254236
ENSG00000179750 breast cancer 29324969
ENSG00000179750 breast cancer 29404275
ENSG00000179750 bladder cancer 29435122
ENSG00000179750 tumor 29618650
ENSG00000179750 cancers 29624320
ENSG00000179750 tumor 29642934
ENSG00000179750 cancer 29693745
ENSG00000179750 cancers 29695832
ENSG00000179750 cancers 29787764
ENSG00000179750 ovarian cancer 29853799
ENSG00000179750 tumors 29856501
ENSG00000179750 oropharyngeal cancers 29950685
ENSG00000179750 cancers 29963239
ENSG00000179750 breast cancer 30093965
ENSG00000179750 tumors 30095460
ENSG00000179750 cancers 30130104
ENSG00000179750 lung cancer 30154666
ENSG00000179750 breast cancer 30226610
ENSG00000179750 Cancer 30233553
ENSG00000179750 cancer 30242938
ENSG00000179750 tumor 30294666
ENSG00000179750 Tumor 30348839
ENSG00000179750 cancers 30417129
ENSG00000179750 breast cancer 30425937
ENSG00000179750 cancer 30457868
ENSG00000179750 gastric cancers 30514953
ENSG00000179750 tumours 30515368
ENSG00000179750 cancers 30575099
ENSG00000179750 cancers 30591678
ENSG00000179750 cancer 30624727
ENSG00000179750 cervical cancer 30631898
ENSG00000179750 cancers 30647454
ENSG00000179750 cancer 30679716
ENSG00000179750 cancer 30723127
ENSG00000179750 cancer 30759888
ENSG00000179750 tumors 30840888
ENSG00000179750 cancer 30849372
ENSG00000179750 tumor 30940643
ENSG00000179750 tumors 30980272
ENSG00000179750 tumor virus infections 30988755
ENSG00000179750 tumour 31073151
ENSG00000179750 tumours 31154396
ENSG00000179750 tumor 31165764
ENSG00000179750 tumor 31217276
ENSG00000179750 cancer 31277598
ENSG00000179750 tumor 31322199
ENSG00000179750 Invasive Breast Cancer 31357602
ENSG00000179750 Cancer 31392335
ENSG00000179750 kidney cancers 31533728
ENSG00000179750 tumor 31544853
ENSG00000179750 gastric cancer 31571995
ENSG00000179750 cancer 31603457
ENSG00000179750 cancers 31611371
ENSG00000179750 cancer 31726973
ENSG00000179750 breast cancer 31728407
ENSG00000179750 breast cancer 31841499
ENSG00000179750 breast tumors 31856876
ENSG00000179750 breast cancer 31904337
ENSG00000179750 cancers 31914134
ENSG00000179750 breast cancer 31930332
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000179750 colon adenocarcinoma missense_variant 2.493% (18/722) 3 entries
ENSG00000179750 colon adenocarcinoma sequence_alteration 2.493% (18/722) 2 entries
ENSG00000179750 lung adenocarcinoma missense_variant 0.172% (2/1163) 1 entry
ENSG00000179750 skin melanoma missense_variant 0.3102% (3/967) 1 entry
ENSG00000179750 gastric adenocarcinoma missense_variant 0.5376% (3/558) 1 entry
ENSG00000179750 squamous cell lung carcinoma sequence_alteration 0.2625% (2/762) 1 entry
ENSG00000179750 colorectal adenocarcinoma missense_variant 0.3515% (4/1138) 1 entry
ENSG00000179750 prostate adenocarcinoma missense_variant 0.2751% (4/1454) 1 entry
ENSG00000179750 nasopharyngeal squamous cell carcinoma missense_variant 1.255% (3/239) 1 entry
ENSG00000179750 clear cell renal carcinoma missense_variant 0.155% (2/1290) 1 entry
ENSG00000179750 nasopharyngeal squamous cell carcinoma frameshift_variant 1.255% (3/239) 1 entry
ENSG00000179750 Brain Stem Glioblastoma sequence_alteration 1.786% (1/56) 1 entry
ENSG00000179750 Unclassified Renal Cell Carcinoma frameshift_variant 6.667% (1/15) 1 entry
ENSG00000179750 gastric intestinal type adenocarcinoma missense_variant 1.176% (1/85) 1 entry
ENSG00000179750 female breast carcinoma missense_variant 0.3745% (1/267) 1 entry
ENSG00000179750 melanoma sequence_alteration 0.9901% (1/101) 1 entry
ENSG00000179750 clear cell renal carcinoma frameshift_variant 0.155% (2/1290) 1 entry
ENSG00000179750 nasopharyngeal squamous cell carcinoma sequence_alteration 1.255% (3/239) 1 entry
ENSG00000179750 basal cell carcinoma missense_variant 1.724% (1/58) 1 entry
ENSG00000179750 cecum adenocarcinoma sequence_alteration 0.8% (1/125) 1 entry
ENSG00000179750 osteosarcoma sequence_alteration 0.8621% (1/116) 1 entry
ENSG00000179750 prostate carcinoma sequence_alteration 0.2347% (1/426) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000179750 SARC 0.048 high
ENSG00000179750 UVM 0.00015 high
ENSG00000179750 PAAD 3e-04 high
ENSG00000179750 LUSC 0.015 low
ENSG00000179750 HNSC 0.0096 low
ENSG00000179750 KICH 0.0017 high
ENSG00000179750 PCPG 0.00052 high
ENSG00000179750 THYM 0.0022 high
ENSG00000179750 BRCA 0.037 high
ENSG00000179750 UCS 0.023 high
ENSG00000179750 OV 0.042 low
ENSG00000179750 TGCT 0.025 low
ENSG00000179750 LAML 0.03 high
ENSG00000179750 SKCM 0.02 high
ENSG00000179750 LIHC 0.013 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000179750 THYM Del 1.199597 0.051052 0.435240 0.138211
ENSG00000179750 SKCM Amp 2.409128 0.173180 0.598678 0.384196