Ensembl ID ENSG00000178607 Gene ID 2081 Accession 3449
Gene Symbol ERN1 Alias IRE1;IRE1P;IRE1a;hIRE1p Full Name endoplasmic reticulum to nucleus signaling 1
Position 17 : 64039080 - 64130819 Length 91740 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017]

ENSG00000178607 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000178607 ERN1 0.42 6.68e-11 KIRC
ENSG00000178607 ERN1 -0.9 3.47e-25 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000178607 ERN1 tumor 16472113
ENSG00000178607 ERN1 tumor 16861911
ENSG00000178607 ERN1 tumor 17638880
ENSG00000178607 ERN1 tumour 18410446
ENSG00000178607 ERN1 cancer 1962622
ENSG00000178607 ERN1 prostate cancer 20013084
ENSG00000178607 ERN1 cancer 20221394
ENSG00000178607 ERN1 tumors 20702765
ENSG00000178607 ERN1 cancer 21407177
ENSG00000178607 ERN1 cancer 21663964
ENSG00000178607 ERN1 tumour 21693538
ENSG00000178607 ERN1 tumor 21746806
ENSG00000178607 ERN1 cancers 21757700
ENSG00000178607 ERN1 tumor 22014571
ENSG00000178607 ERN1 cancer 22314839
ENSG00000178607 ERN1 prostate cancer 22470469
ENSG00000178607 ERN1 ovarian cancer 22564965
ENSG00000178607 ERN1 breast cancer 22681620
ENSG00000178607 ERN1 tumor 22718352
ENSG00000178607 ERN1 tumor 22733998
ENSG00000178607 ERN1 tumors 22852048
ENSG00000178607 ERN1 liver cancer 23041544
ENSG00000178607 ERN1 cancer 23050960
ENSG00000178607 ERN1 breast cancer 23110043
ENSG00000178607 ERN1 breast cancer 23196055
ENSG00000178607 ERN1 tumor 23363253
ENSG00000178607 ERN1 prostate cancer 23448667
ENSG00000178607 ERN1 tumor 23572207
ENSG00000178607 ERN1 tumor 23752693
ENSG00000178607 ERN1 tumour 23942232
ENSG00000178607 ERN1 tumor 24039668
ENSG00000178607 ERN1 prostate cancer 24042854
ENSG00000178607 ERN1 tumors 24043762
ENSG00000178607 ERN1 tumour 24089213
ENSG00000178607 ERN1 tumor 24175483
ENSG00000178607 ERN1 tumor 24330607
ENSG00000178607 ERN1 tumors 24339898
ENSG00000178607 ERN1 cancer 24362465
ENSG00000178607 ERN1 tumors 24367269
ENSG00000178607 ERN1 colon cancer 24378333
ENSG00000178607 ERN1 malignant tumor 24479318
ENSG00000178607 ERN1 cancers 24524643
ENSG00000178607 ERN1 colon cancer 24565834
ENSG00000178607 ERN1 tumors 24705207
ENSG00000178607 ERN1 breast cancer 24745346
ENSG00000178607 ERN1 pancreatic cancers 24952679
ENSG00000178607 ERN1 breast cancer 24970676
ENSG00000178607 ERN1 GBM 25252179
ENSG00000178607 ERN1 tumor 25337575
ENSG00000178607 ERN1 breast cancer 25339305
ENSG00000178607 ERN1 breast cancer 25347741
ENSG00000178607 ERN1 cancers 25385277
ENSG00000178607 ERN1 pancreatic cancer 25481044
ENSG00000178607 ERN1 cancer 25493075
ENSG00000178607 ERN1 malignant tumors 25509187
ENSG00000178607 ERN1 Cancer 25522186
ENSG00000178607 ERN1 tumor 25533479
ENSG00000178607 ERN1 cancer 25548511
ENSG00000178607 ERN1 Tumor 25589933
ENSG00000178607 ERN1 tumors 25594042
ENSG00000178607 ERN1 tumors 25598862
ENSG00000178607 ERN1 pancreatic cancer 25657029
ENSG00000178607 ERN1 cancer 25692126
ENSG00000178607 ERN1 Cancer 25789991
ENSG00000178607 ERN1 cancer 25794824
ENSG00000178607 ERN1 cancer 25804756
ENSG00000178607 ERN1 tumor 25816608
ENSG00000178607 ERN1 tumor 25849745
ENSG00000178607 ERN1 prostate cancer 25864123
ENSG00000178607 ERN1 cancer 25870107
ENSG00000178607 ERN1 colon cancer 25901510
ENSG00000178607 ERN1 tumor 25901709
ENSG00000178607 ERN1 cancer 25927911
ENSG00000178607 ERN1 tumor 25941664
ENSG00000178607 ERN1 tumor 25960008
ENSG00000178607 ERN1 triple-negative breast cancer 25968568
ENSG00000178607 ERN1 breast cancers 26012635
ENSG00000178607 ERN1 Cancer 26069288
ENSG00000178607 ERN1 cervical cancer 26134873
ENSG00000178607 ERN1 cancer 26254280
ENSG00000178607 ERN1 tumor 26255341
ENSG00000178607 ERN1 ovarian cancer 26261528
ENSG00000178607 ERN1 breast cancer 26268696
ENSG00000178607 ERN1 tumors 26325176
ENSG00000178607 ERN1 gallbladder cancer 26361144
ENSG00000178607 ERN1 cancer 26491226
ENSG00000178607 ERN1 tumor 26494037
ENSG00000178607 ERN1 breast cancer 26517687
ENSG00000178607 ERN1 non-small cell lung cancer 26549806
ENSG00000178607 ERN1 cancer 26584019
ENSG00000178607 ERN1 cancer 26622781
ENSG00000178607 ERN1 cancer 26627053
ENSG00000178607 ERN1 tumor 26646564
ENSG00000178607 ERN1 tumor 26742428
ENSG00000178607 ERN1 cancer 26910807
ENSG00000178607 ERN1 GBM 26923166
ENSG00000178607 ERN1 tumour 26927180
ENSG00000178607 ERN1 cancers 26934650
ENSG00000178607 ERN1 Tumor 26979393
ENSG00000178607 ERN1 tumor 27025058
ENSG00000178607 ERN1 tumor 27025059
ENSG00000178607 ERN1 cancer 27059255
ENSG00000178607 ERN1 GBM 27106078
ENSG00000178607 ERN1 breast cancer 27109102
ENSG00000178607 ERN1 cancer 27141359
ENSG00000178607 ERN1 tumour 27270308
ENSG00000178607 ERN1 cancers 27303918
ENSG00000178607 ERN1 cancer 27322083
ENSG00000178607 ERN1 cancer 27452337
ENSG00000178607 ERN1 non-small cell lung cancer 27470364
ENSG00000178607 ERN1 tumor 27560636
ENSG00000178607 ERN1 cancer 27626662
ENSG00000178607 ERN1 cancers 27634301
ENSG00000178607 ERN1 breast cancer 27829216
ENSG00000178607 ERN1 gallbladder cancer 27847321
ENSG00000178607 ERN1 tumors 28070992
ENSG00000178607 ERN1 tumor 28105371
ENSG00000178607 ERN1 tumor 28134767
ENSG00000178607 ERN1 tumors 28148690
ENSG00000178607 ERN1 DLBCL 28167662
ENSG00000178607 ERN1 cancers 28222747
ENSG00000178607 ERN1 tumor 28319895
ENSG00000178607 ERN1 prostate cancer 28338058
ENSG00000178607 ERN1 tumors 28339041
ENSG00000178607 ERN1 cervical cancer 28358375
ENSG00000178607 ERN1 Tumour 28379196
ENSG00000178607 ERN1 cancer 28380378
ENSG00000178607 ERN1 GBM 28428258
ENSG00000178607 ERN1 tumor 28454221
ENSG00000178607 ERN1 cancer 28491820
ENSG00000178607 ERN1 cancer 28540288
ENSG00000178607 ERN1 tumors 28550308
ENSG00000178607 ERN1 pancreatic cancer 28618969
ENSG00000178607 ERN1 tumor 28672279
ENSG00000178607 ERN1 cancer 28710693
ENSG00000178607 ERN1 non-small Cell Lung Cancer 28730963
ENSG00000178607 ERN1 tumor 28741511
ENSG00000178607 ERN1 tumor 28749466
ENSG00000178607 ERN1 colon cancer 28825721
ENSG00000178607 ERN1 tumor 28846078
ENSG00000178607 ERN1 tumor 28847931
ENSG00000178607 ERN1 cancer 28971800
ENSG00000178607 ERN1 cancer 29024602
ENSG00000178607 ERN1 tumor 29066771
ENSG00000178607 ERN1 breast cancer 29113324
ENSG00000178607 ERN1 tumor 29209327
ENSG00000178607 ERN1 tumor 29227074
ENSG00000178607 ERN1 tumor 29227599
ENSG00000178607 ERN1 tumor 29235326
ENSG00000178607 ERN1 tumor 29235796
ENSG00000178607 ERN1 tumor 29236388
ENSG00000178607 ERN1 cancer 29263275
ENSG00000178607 ERN1 prostate cancer 29308051
ENSG00000178607 ERN1 tumor 29311133
ENSG00000178607 ERN1 liver cancer 29355527
ENSG00000178607 ERN1 breast cancer 29367761
ENSG00000178607 ERN1 cancers 29381485
ENSG00000178607 ERN1 tumour 29415493
ENSG00000178607 ERN1 tumor 29430279
ENSG00000178607 ERN1 tumor 29440447
ENSG00000178607 ERN1 breast cancer 29480818
ENSG00000178607 ERN1 tumor 29506314
ENSG00000178607 ERN1 tumor 29531800
ENSG00000178607 ERN1 tumor 29537195
ENSG00000178607 ERN1 tumor 29551590
ENSG00000178607 ERN1 tumor 29581854
ENSG00000178607 ERN1 tumor 29663887
ENSG00000178607 ERN1 lung cancer 29719463
ENSG00000178607 ERN1 cancer 29783691
ENSG00000178607 ERN1 Tumor 29804923
ENSG00000178607 ERN1 breast cancer 29888341
ENSG00000178607 ERN1 tumor 29986726
ENSG00000178607 ERN1 tumor 30062064
ENSG00000178607 ERN1 cancer 30081573
ENSG00000178607 ERN1 breast cancer 30111846
ENSG00000178607 ERN1 tumour 30134550
ENSG00000178607 ERN1 gastric cancer 30158521
ENSG00000178607 ERN1 cancer 30159133
ENSG00000178607 ERN1 GBM 30233358
ENSG00000178607 ERN1 tumour 30248920
ENSG00000178607 ERN1 tumor 30282948
ENSG00000178607 ERN1 pancreatic cancer 30294322
ENSG00000178607 ERN1 ovarian cancer 30305738
ENSG00000178607 ERN1 tumor 30355343
ENSG00000178607 ERN1 tumor 30405792
ENSG00000178607 ERN1 tumor 30411035
ENSG00000178607 ERN1 colon cancers 30482246
ENSG00000178607 ERN1 lung cancer 30504895
ENSG00000178607 ERN1 ovarian cancers 30517892
ENSG00000178607 ERN1 cancer 30529847
ENSG00000178607 ERN1 cancer 30565689
ENSG00000178607 ERN1 tumor 30607156
ENSG00000178607 ERN1 prostate cancer 30679434
ENSG00000178607 ERN1 tumor 30687308
ENSG00000178607 ERN1 tumor 30713500
ENSG00000178607 ERN1 tumor 30717537
ENSG00000178607 ERN1 tumor 30754624
ENSG00000178607 ERN1 cancer 30779566
ENSG00000178607 ERN1 lung cancer 30813301
ENSG00000178607 ERN1 colon cancer 30824833
ENSG00000178607 ERN1 cancer 30857233
ENSG00000178607 ERN1 tumor 30863482
ENSG00000178607 ERN1 GBM 30930246
ENSG00000178607 ERN1 tumor 30936991
ENSG00000178607 ERN1 breast cancer 31022492
ENSG00000178607 ERN1 cancer 31041814
ENSG00000178607 ERN1 tumors 31052524
ENSG00000178607 ERN1 tumor 31062076
ENSG00000178607 ERN1 tumor 31064137
ENSG00000178607 ERN1 tumours 31071975
ENSG00000178607 ERN1 cancer 31080802
ENSG00000178607 ERN1 cancer 31086333
ENSG00000178607 ERN1 tumor 31138662
ENSG00000178607 ERN1 tumor 31151143
ENSG00000178607 ERN1 tumors 31180176
ENSG00000178607 ERN1 tumors 31187548
ENSG00000178607 ERN1 cancer 31205564
ENSG00000178607 ERN1 colorectal cancer 31243264
ENSG00000178607 ERN1 tumor 31281809
ENSG00000178607 ERN1 cancer 31285958
ENSG00000178607 ERN1 tumor 31320625
ENSG00000178607 ERN1 stomach cancer 31325684
ENSG00000178607 ERN1 colon cancer 31326465
ENSG00000178607 ERN1 cancer 31371506
ENSG00000178607 ERN1 tumor 31387940
ENSG00000178607 ERN1 cancers 31410019
ENSG00000178607 ERN1 bone cancer 31452457
ENSG00000178607 ERN1 tumor 31453810
ENSG00000178607 ERN1 Tumor 31491919
ENSG00000178607 ERN1 tumors 31496655
ENSG00000178607 ERN1 ovarian cancer 31535086
ENSG00000178607 ERN1 tumour 31572192
ENSG00000178607 ERN1 tumors 31597321
ENSG00000178607 ERN1 liver cancer 31598149
ENSG00000178607 ERN1 tumors 31666439
ENSG00000178607 ERN1 Pancreatic Neuroendocrine Tumor 31672843
ENSG00000178607 ERN1 ovarian cancer 31719837
ENSG00000178607 ERN1 cancer 31767828
ENSG00000178607 ERN1 tumor 31819768
ENSG00000178607 ERN1 colon cancer 31865182
ENSG00000178607 ERN1 cancer 31866782
ENSG00000178607 ERN1 Colorectal Cancer 31930117
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000178607 ERN1 MESO 0.006 low
ENSG00000178607 ERN1 SARC 0.049 low
ENSG00000178607 ERN1 UCEC 0.0052 low
ENSG00000178607 ERN1 THCA 0.012 low
ENSG00000178607 ERN1 ACC 0.00066 high
ENSG00000178607 ERN1 LUSC 0.0016 high
ENSG00000178607 ERN1 HNSC 0.037 low
ENSG00000178607 ERN1 KIRP 0.00079 high
ENSG00000178607 ERN1 KICH 0.01 high
ENSG00000178607 ERN1 LUAD 0.0056 low
ENSG00000178607 ERN1 ESCA 0.036 low
ENSG00000178607 ERN1 KIRC 0.018 high
ENSG00000178607 ERN1 SKCM 0.026 low
ENSG00000178607 ERN1 CESC 0.014 high
ENSG00000178607 ERN1 LIHC 0.05 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000178607 ERN1 LUAD Amp 1.356091 0.134592 0.391730 0.484496
ENSG00000178607 ERN1 KIRP Amp 0.627742 0.050882 0.716444 0.690972
ENSG00000178607 ERN1 COAD Amp 0.702296 0.067275 0.505137 0.228381
ENSG00000178607 ERN1 PAAD Del 4.022713 0.104735 0.373082 0.222826
ENSG00000178607 ERN1 SKCM Amp 5.186471 0.247406 0.566160 0.335150
ENSG00000178607 ERN1 LIHC Amp 5.415940 0.214682 0.663597 0.354054
ENSG00000178607 ERN1 BLCA Amp 3.364282 0.249555 0.508288 0.473039
ENSG00000178607 ERN1 BRCA Amp 54.087520 0.573156 0.863487 0.395370
ENSG00000178607 ERN1 UCEC Amp 0.846069 0.106784 0.577624 0.124304
ENSG00000178607 ERN1 UVM Amp 0.721460 0.165534 0.811066 0.162500