Ensembl ID ENSG00000178105 Gene ID 1662 Accession 2735
Gene Symbol DDX10 Alias Dbp4;HRH-J8 Full Name DEAD-box helicase 10
Position 11 : 108665067 - 108940999 Length 275933 bases Strand Plus strand
Status Confidence Main interacting RNAsrRNARBP type Canonical_RBPs
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. [provided by RefSeq, Jul 2008]

ENSG00000178105 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000178105 DDX10 1.06 1.70e-40 COAD
ENSG00000178105 DDX10 1.00 1.05e-28 LUSC
ENSG00000178105 DDX10 0.71 6.94e-14 STAD
ENSG00000178105 DDX10 0.57 8.24e-14 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000178105 DDX10 AML 10397741
ENSG00000178105 DDX10 AML 10502319
ENSG00000178105 DDX10 breast cancer 23496902
ENSG00000178105 DDX10 ovarian cancer 26713367
ENSG00000178105 DDX10 cancer 31675377
ENSG00000178105 DDX10 AML 9766650
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000178105 DDX10 prostate adenocarcinoma frameshift_variant 7.497% (109/1454) 1 entry
ENSG00000178105 DDX10 esophageal adenocarcinoma missense_variant 12.56% (55/438) 2 entries
ENSG00000178105 DDX10 breast ductal adenocarcinoma sequence_alteration 15.88% (98/617) 1 entry
ENSG00000178105 DDX10 prostate carcinoma missense_variant 4.545% (22/484) 2 entries
ENSG00000178105 DDX10 breast ductal adenocarcinoma missense_variant 15.88% (98/617) 1 entry
ENSG00000178105 DDX10 clear cell renal carcinoma sequence_alteration 0.6531% (9/1378) 1 entry
ENSG00000178105 DDX10 prostate carcinoma sequence_alteration 4.545% (22/484) 1 entry
ENSG00000178105 DDX10 colorectal adenocarcinoma missense_variant 3.515% (40/1138) 2 entries
ENSG00000178105 DDX10 oral squamous cell carcinoma missense_variant 1.951% (4/205) 1 entry
ENSG00000178105 DDX10 oral squamous cell carcinoma amino_acid_insertion 1.951% (4/205) 1 entry
ENSG00000178105 DDX10 esophageal squamous cell carcinoma missense_variant 1.185% (8/675) 4 entries
ENSG00000178105 DDX10 basal cell carcinoma missense_variant 5.172% (3/58) 1 entry
ENSG00000178105 DDX10 lung adenocarcinoma missense_variant 0.8197% (10/1220) 4 entries
ENSG00000178105 DDX10 squamous cell lung carcinoma sequence_alteration 0.8485% (7/825) 2 entries
ENSG00000178105 DDX10 colon adenocarcinoma stop_gained 2.571% (19/739) 1 entry
ENSG00000178105 DDX10 colon adenocarcinoma frameshift_variant 2.571% (19/739) 2 entries
ENSG00000178105 DDX10 melanoma missense_variant 6.931% (7/101) 2 entries
ENSG00000178105 DDX10 skin melanoma sequence_alteration 1.138% (11/967) 2 entries
ENSG00000178105 DDX10 central nervous system primitive neuroectodermal neoplasm sequence_alteration 1.126% (5/444) 1 entry
ENSG00000178105 DDX10 Brain Stem Glioblastoma sequence_alteration 5.357% (3/56) 1 entry
ENSG00000178105 DDX10 colorectal adenocarcinoma sequence_alteration 3.515% (40/1138) 2 entries
ENSG00000178105 DDX10 prostate adenocarcinoma stop_gained 7.497% (109/1454) 1 entry
ENSG00000178105 DDX10 melanoma conservative_inframe_deletion 6.931% (7/101) 2 entries
ENSG00000178105 DDX10 diffuse large B-cell lymphoma frameshift_variant 0.9901% (3/303) 1 entry
ENSG00000178105 DDX10 breast ductal adenocarcinoma stop_gained 15.88% (98/617) 1 entry
ENSG00000178105 DDX10 squamous cell lung carcinoma missense_variant 0.8485% (7/825) 2 entries
ENSG00000178105 DDX10 HER2 Positive Breast Carcinoma missense_variant 11.39% (18/158) 1 entry
ENSG00000178105 DDX10 chronic lymphocytic leukemia sequence_alteration 2.252% (20/888) 1 entry
ENSG00000178105 DDX10 myelodysplastic syndrome sequence_alteration 2.703% (2/74) 1 entry
ENSG00000178105 DDX10 skin melanoma missense_variant 1.138% (11/967) 1 entry
ENSG00000178105 DDX10 female breast carcinoma missense_variant 0.7673% (3/391) 1 entry
ENSG00000178105 DDX10 small cell lung carcinoma missense_variant 1.231% (4/325) 2 entries
ENSG00000178105 DDX10 colon adenocarcinoma missense_variant 2.571% (19/739) 5 entries
ENSG00000178105 DDX10 colorectal adenocarcinoma frameshift_variant 3.515% (40/1138) 2 entries
ENSG00000178105 DDX10 rectal adenocarcinoma stop_gained 1.31% (3/229) 1 entry
ENSG00000178105 DDX10 nasopharyngeal squamous cell carcinoma missense_variant 0.5988% (1/167) 1 entry
ENSG00000178105 DDX10 medulloblastoma sequence_alteration 4.167% (1/24) 1 entry
ENSG00000178105 DDX10 small cell lung carcinoma frameshift_variant 1.231% (4/325) 1 entry
ENSG00000178105 DDX10 Ovarian Endometrioid Adenocarcinoma frameshift_variant 100.0% (1/1) 1 entry
ENSG00000178105 DDX10 osteosarcoma missense_variant 0.8621% (1/116) 1 entry
ENSG00000178105 DDX10 gastric intestinal type adenocarcinoma amino_acid_insertion 2.353% (2/85) 1 entry
ENSG00000178105 DDX10 hemangioblastoma frameshift_variant 10.0% (1/10) 1 entry
ENSG00000178105 DDX10 small cell lung carcinoma sequence_alteration 1.231% (4/325) 1 entry
ENSG00000178105 DDX10 bile duct adenocarcinoma missense_variant 0.5291% (1/189) 1 entry
ENSG00000178105 DDX10 Mixed Lobular and Ductal Breast Carcinoma conservative_inframe_deletion 25.0% (1/4) 1 entry
ENSG00000178105 DDX10 angiosarcoma sequence_alteration 7.692% (1/13) 1 entry
ENSG00000178105 DDX10 head and neck squamous cell carcinoma amino_acid_insertion 0.1597% (1/626) 1 entry
ENSG00000178105 DDX10 basal cell carcinoma sequence_alteration 5.172% (3/58) 1 entry
ENSG00000178105 DDX10 melanoma sequence_alteration 6.931% (7/101) 1 entry
ENSG00000178105 DDX10 Mantle cell lymphoma amino_acid_insertion 2.439% (1/41) 1 entry
ENSG00000178105 DDX10 gastric intestinal type adenocarcinoma missense_variant 2.353% (2/85) 1 entry
ENSG00000178105 DDX10 colon adenocarcinoma sequence_alteration 2.571% (19/739) 1 entry
ENSG00000178105 DDX10 Endometrial Endometrioid Adenocarcinoma frameshift_variant 2.178% (12/551) 1 entry
ENSG00000178105 DDX10 colorectal adenocarcinoma stop_gained 3.515% (40/1138) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000178105 DDX10 MESO 0.049 high
ENSG00000178105 DDX10 STAD 0.02 low
ENSG00000178105 DDX10 CHOL 0.0041 low
ENSG00000178105 DDX10 PAAD 0.00046 high
ENSG00000178105 DDX10 ACC 0.00022 high
ENSG00000178105 DDX10 LUSC 0.048 low
ENSG00000178105 DDX10 HNSC 0.004 high
ENSG00000178105 DDX10 READ 0.024 low
ENSG00000178105 DDX10 KIRP 0.0025 low
ENSG00000178105 DDX10 KICH 0.0022 high
ENSG00000178105 DDX10 LUAD 0.03 high
ENSG00000178105 DDX10 BRCA 0.049 low
ENSG00000178105 DDX10 DLBC 0.0092 low
ENSG00000178105 DDX10 KIRC 0.00023 low
ENSG00000178105 DDX10 PRAD 0.0097 low
ENSG00000178105 DDX10 BLCA 0.0059 high
ENSG00000178105 DDX10 SKCM 0.0026 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000178105 DDX10 LUSC Del 1.840954 0.081253 0.344057 0.337325
ENSG00000178105 DDX10 LUAD Del 3.777257 0.083507 0.337165 0.230620
ENSG00000178105 DDX10 CESC Del 19.623633 0.251028 0.559528 0.522034
ENSG00000178105 DDX10 KIRP Del 5.964384 0.072177 0.591714 0.107639
ENSG00000178105 DDX10 SARC Del 5.049337 0.217373 0.555178 0.443580
ENSG00000178105 DDX10 ESCA Del 1.869325 0.129447 0.443731 0.407609
ENSG00000178105 DDX10 SKCM Del 21.910772 0.251340 0.550686 0.550409
ENSG00000178105 DDX10 HNSC Del 13.550507 0.140205 0.436539 0.455939
ENSG00000178105 DDX10 LIHC Del 1.496320 0.078712 0.477968 0.243243
ENSG00000178105 DDX10 TGCT Del 3.189163 0.108265 0.466318 0.800000
ENSG00000178105 DDX10 BLCA Del 2.548392 0.105877 0.408800 0.372549
ENSG00000178105 DDX10 BRCA Del 45.480781 0.215728 0.528509 0.487037
ENSG00000178105 DDX10 STAD Del 1.470071 0.071686 0.354132 0.199546
ENSG00000178105 DDX10 PRAD Del 2.008084 0.088240 0.497478 0.087398
ENSG00000178105 DDX10 UCEC Del 1.794089 0.061263 0.519105 0.161410
ENSG00000178105 DDX10 OV Del 0.774666 0.175954 0.534657 0.300518