Ensembl ID ENSG00000178035 Gene ID 3615 Accession 6053
Gene Symbol IMPDH2 Alias IMPD2;IMPDH-II Full Name inosine monophosphate dehydrogenase 2
Position 3 : 49024325 - 49029426 Length 5102 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]

ENSG00000178035 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000178035 IMPDH2 0.84 5.92e-18 COAD
ENSG00000178035 IMPDH2 0.89 7.66e-20 PRAD
ENSG00000178035 IMPDH2 0.87 4.23e-13 LIHC
ENSG00000178035 IMPDH2 0.60 2.73e-11 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000178035 IMPDH2 colon cancer 15670151
ENSG00000178035 IMPDH2 gastric cancer 16609701
ENSG00000178035 IMPDH2 tumor 18976158
ENSG00000178035 IMPDH2 cancer 19583440
ENSG00000178035 IMPDH2 colorectal cancer 19597826
ENSG00000178035 IMPDH2 malignant brain tumor 22192797
ENSG00000178035 IMPDH2 tumor 22215415
ENSG00000178035 IMPDH2 cancer 22220215
ENSG00000178035 IMPDH2 tumors 23322277
ENSG00000178035 IMPDH2 cervical cancer 24231526
ENSG00000178035 IMPDH2 cancer 24429698
ENSG00000178035 IMPDH2 cancer 24477477
ENSG00000178035 IMPDH2 tumor 24659377
ENSG00000178035 IMPDH2 cancer 25347121
ENSG00000178035 IMPDH2 bladder cancer 25465060
ENSG00000178035 IMPDH2 prostate cancer 25869206
ENSG00000178035 IMPDH2 cancer 26467706
ENSG00000178035 IMPDH2 cancer 26918043
ENSG00000178035 IMPDH2 cancer 26977297
ENSG00000178035 IMPDH2 cancer 28152521
ENSG00000178035 IMPDH2 tumors 28389646
ENSG00000178035 IMPDH2 tumor 28536624
ENSG00000178035 IMPDH2 breast cancer 29962242
ENSG00000178035 IMPDH2 tumor 29966326
ENSG00000178035 IMPDH2 tumors 30043754
ENSG00000178035 IMPDH2 cancer 30158500
ENSG00000178035 IMPDH2 tumor 30210928
ENSG00000178035 IMPDH2 colorectal cancer 30518405
ENSG00000178035 IMPDH2 tumors 30680233
ENSG00000178035 IMPDH2 brain cancer 31371825
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000178035 IMPDH2 SARC 0.0064 high
ENSG00000178035 IMPDH2 CHOL 0.05 low
ENSG00000178035 IMPDH2 UVM 0.0012 low
ENSG00000178035 IMPDH2 ACC 0.0083 high
ENSG00000178035 IMPDH2 LUSC 0.025 low
ENSG00000178035 IMPDH2 READ 0.041 low
ENSG00000178035 IMPDH2 LUAD 0.03 low
ENSG00000178035 IMPDH2 PCPG 0.0034 low
ENSG00000178035 IMPDH2 BRCA 0.013 high
ENSG00000178035 IMPDH2 DLBC 0.032 low
ENSG00000178035 IMPDH2 KIRC 0.0019 high
ENSG00000178035 IMPDH2 PRAD 0.024 high
ENSG00000178035 IMPDH2 BLCA 0.0094 high
ENSG00000178035 IMPDH2 GBM 0.018 low
ENSG00000178035 IMPDH2 SKCM 0.0014 high
ENSG00000178035 IMPDH2 LIHC 0.00078 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000178035 IMPDH2 CHOL Del 1.097134 0.240589 0.628335 0.833333
ENSG00000178035 IMPDH2 LUSC Del 3.406080 0.098325 0.411432 0.864271
ENSG00000178035 IMPDH2 LUAD Del 1.547033 0.062525 0.324393 0.480620
ENSG00000178035 IMPDH2 LGG Del 1.995845 0.052339 0.515147 0.091618
ENSG00000178035 IMPDH2 READ Del 0.949380 0.079394 0.426265 0.157576
ENSG00000178035 IMPDH2 COAD Del 1.231392 0.048491 0.427069 0.155211
ENSG00000178035 IMPDH2 UCS Del 2.534686 0.340261 0.531862 0.607143
ENSG00000178035 IMPDH2 SARC Del 2.062141 0.158817 0.516737 0.252918
ENSG00000178035 IMPDH2 ESCA Del 1.407837 0.117091 0.444812 0.657609
ENSG00000178035 IMPDH2 HNSC Del 0.958465 0.057451 0.434930 0.720307
ENSG00000178035 IMPDH2 DLBC Del 0.853539 0.133076 0.459885 0.166667
ENSG00000178035 IMPDH2 BLCA Del 6.230564 0.145945 0.414961 0.294118
ENSG00000178035 IMPDH2 BRCA Del 28.250280 0.172121 0.460200 0.315741
ENSG00000178035 IMPDH2 STAD Del 5.999521 0.116857 0.348310 0.340136
ENSG00000178035 IMPDH2 UCEC Del 1.235835 0.055036 0.490413 0.124304
ENSG00000178035 IMPDH2 MESO Del 17.375115 0.551280 0.569638 0.517241
ENSG00000178035 IMPDH2 KIRC Del 50.872801 0.179827 0.515750 0.880682
ENSG00000178035 IMPDH2 OV Del 2.083158 0.204002 0.486102 0.336788