Ensembl ID ENSG00000177885 Gene ID 2885 Accession 4566
Gene Symbol GRB2 Alias ASH;Grb3-3;MST084;NCKAP2;MSTP084;EGFRBP-GRB2 Full Name growth factor receptor bound protein 2
Position 17 : 75318076 - 75405709 Length 87634 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ENSG00000177885 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000177885 GRB2 0.73 1.15e-33 BRCA
ENSG00000177885 GRB2 -0.3 3.07e-15 COAD
ENSG00000177885 GRB2 0.59 1.37e-14 KIRP
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000177885 GRB2 breast cancer 10022814
ENSG00000177885 GRB2 breast cancer 11054664
ENSG00000177885 GRB2 breast cancer 11175341
ENSG00000177885 GRB2 breast cancer 11250710
ENSG00000177885 GRB2 breast cancer 12531430
ENSG00000177885 GRB2 cancer 16165154
ENSG00000177885 GRB2 tumors 16457699
ENSG00000177885 GRB2 cancers 16480678
ENSG00000177885 GRB2 tumors 16773180
ENSG00000177885 GRB2 tumor 17616655
ENSG00000177885 GRB2 cancer 18620523
ENSG00000177885 GRB2 tumor 18989951
ENSG00000177885 GRB2 pancreatic cancer 19307239
ENSG00000177885 GRB2 tumour 19382019
ENSG00000177885 GRB2 tumors 19393836
ENSG00000177885 GRB2 tumor 19531230
ENSG00000177885 GRB2 tumor 19836242
ENSG00000177885 GRB2 tumor 20512084
ENSG00000177885 GRB2 cancer 22285593
ENSG00000177885 GRB2 gastric cancer 22383989
ENSG00000177885 GRB2 tumors 22465879
ENSG00000177885 GRB2 tumors 22521882
ENSG00000177885 GRB2 lung cancer 23027861
ENSG00000177885 GRB2 tumor 23183748
ENSG00000177885 GRB2 breast cancer 23314696
ENSG00000177885 GRB2 cancer 23373509
ENSG00000177885 GRB2 tumor 23826330
ENSG00000177885 GRB2 urinary bladder cancer 23936786
ENSG00000177885 GRB2 cancer 24173294
ENSG00000177885 GRB2 lung cancer 24189400
ENSG00000177885 GRB2 tumor 24391994
ENSG00000177885 GRB2 cancer 24739176
ENSG00000177885 GRB2 breast cancer 24939894
ENSG00000177885 GRB2 prostate cancer 25153383
ENSG00000177885 GRB2 cancer 25252636
ENSG00000177885 GRB2 breast cancer 25445394
ENSG00000177885 GRB2 tumor 25580584
ENSG00000177885 GRB2 tumor 25587191
ENSG00000177885 GRB2 cancer 25814554
ENSG00000177885 GRB2 tumor 26204832
ENSG00000177885 GRB2 lung cancer 26402252
ENSG00000177885 GRB2 tumor 26418977
ENSG00000177885 GRB2 breast cancer 26458823
ENSG00000177885 GRB2 ovarian cancer 26576679
ENSG00000177885 GRB2 pancreatic cancer 26885689
ENSG00000177885 GRB2 cancer 27041574
ENSG00000177885 GRB2 lung cancer 27210447
ENSG00000177885 GRB2 breast cancer 27264952
ENSG00000177885 GRB2 cancer 27418131
ENSG00000177885 GRB2 tumor 27602113
ENSG00000177885 GRB2 Lung Cancer 27802291
ENSG00000177885 GRB2 tumor 27906191
ENSG00000177885 GRB2 cancer 28300825
ENSG00000177885 GRB2 cancer 28322937
ENSG00000177885 GRB2 cancer 28417283
ENSG00000177885 GRB2 Tumour 28432311
ENSG00000177885 GRB2 cancer 28436261
ENSG00000177885 GRB2 tumour 28470949
ENSG00000177885 GRB2 breast cancer 28487699
ENSG00000177885 GRB2 cancer 28521404
ENSG00000177885 GRB2 tumors 28855353
ENSG00000177885 GRB2 breast cancer 28912526
ENSG00000177885 GRB2 cancer 28938536
ENSG00000177885 GRB2 cancer 29296185
ENSG00000177885 GRB2 tumor 29416005
ENSG00000177885 GRB2 tumor 29435111
ENSG00000177885 GRB2 Cancer 29440291
ENSG00000177885 GRB2 cancer 29523843
ENSG00000177885 GRB2 breast cancer 29927945
ENSG00000177885 GRB2 tumor 30059495
ENSG00000177885 GRB2 non-small-cell lung cancer 30069987
ENSG00000177885 GRB2 lung cancer 30087284
ENSG00000177885 GRB2 breast cancer 30128822
ENSG00000177885 GRB2 ovarian cancer 30257357
ENSG00000177885 GRB2 cancer 30327774
ENSG00000177885 GRB2 tumor 30588667
ENSG00000177885 GRB2 tumor 30605687
ENSG00000177885 GRB2 ovarian cancers 30755818
ENSG00000177885 GRB2 cancer 30867905
ENSG00000177885 GRB2 breast cancer 31036036
ENSG00000177885 GRB2 cancer 31394634
ENSG00000177885 GRB2 lung tumor 31655998
ENSG00000177885 GRB2 cancer 31719636
ENSG00000177885 GRB2 tumor 31737211
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000177885 GRB2 SARC 0.015 low
ENSG00000177885 GRB2 STAD 0.014 low
ENSG00000177885 GRB2 PAAD 0.0089 low
ENSG00000177885 GRB2 UCEC 0.0021 high
ENSG00000177885 GRB2 LGG 0.011 high
ENSG00000177885 GRB2 READ 0.0039 low
ENSG00000177885 GRB2 KIRP 0.011 high
ENSG00000177885 GRB2 PCPG 0.012 high
ENSG00000177885 GRB2 THYM 0.01 low
ENSG00000177885 GRB2 BRCA 0.0047 high
ENSG00000177885 GRB2 UCS 0.039 high
ENSG00000177885 GRB2 OV 0.031 low
ENSG00000177885 GRB2 DLBC 0.013 low
ENSG00000177885 GRB2 KIRC 0.0012 high
ENSG00000177885 GRB2 PRAD 0.043 low
ENSG00000177885 GRB2 TGCT 0.033 high
ENSG00000177885 GRB2 BLCA 0.048 high
ENSG00000177885 GRB2 LAML 0.0028 high
ENSG00000177885 GRB2 SKCM 0.00044 low
ENSG00000177885 GRB2 CESC 0.031 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000177885 GRB2 LUSC Amp 2.043081 0.236787 0.452836 0.469062
ENSG00000177885 GRB2 LUAD Amp 2.648734 0.162612 0.406895 0.494186
ENSG00000177885 GRB2 LGG Amp 4.553874 0.094604 0.657852 0.085770
ENSG00000177885 GRB2 CESC Amp 3.706897 0.231763 0.707432 0.233898
ENSG00000177885 GRB2 UCS Amp 1.243463 0.581786 0.775660 0.535714
ENSG00000177885 GRB2 GBM Amp 2.277495 0.095375 0.487151 0.143847
ENSG00000177885 GRB2 PAAD Del 3.747687 0.098262 0.356137 0.228261
ENSG00000177885 GRB2 ESCA Amp 1.195246 0.291954 0.521576 0.385870
ENSG00000177885 GRB2 SKCM Amp 6.023631 0.267982 0.567431 0.348774
ENSG00000177885 GRB2 LIHC Amp 8.790341 0.270238 0.664007 0.389189
ENSG00000177885 GRB2 BLCA Amp 1.952842 0.208119 0.463362 0.473039
ENSG00000177885 GRB2 BRCA Amp 24.456224 0.382589 0.659807 0.375926
ENSG00000177885 GRB2 STAD Amp 0.996908 0.140796 0.448610 0.213152
ENSG00000177885 GRB2 UCEC Amp 6.561884 0.204183 0.639163 0.181818
ENSG00000177885 GRB2 OV Amp 2.025286 0.375212 0.563409 0.341969