Ensembl ID ENSG00000177469 Gene ID 284119 Accession 9688
Gene Symbol CAVIN1 Alias CGL4;PTRF;CAVIN;FKSG13;cavin-1 Full Name caveolae associated protein 1
Position 17 : 42402449 - 42423256 Length 20808 bases Strand Minus strand
Status Confidence Main interacting RNAsrRNARBP type Non-canonical_RBPs
Summary This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009]

ENSG00000177469 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000177469 CAVIN1 0.83 2.49e-20 KIRC
ENSG00000177469 CAVIN1 -1.8 3.12e-101 BRCA
ENSG00000177469 CAVIN1 -1.3 1.71e-15 COAD
ENSG00000177469 CAVIN1 -1.6 2.40e-37 LUSC
ENSG00000177469 CAVIN1 -1.1 6.18e-20 PRAD
ENSG00000177469 CAVIN1 -2.9 6.89e-68 UCEC
ENSG00000177469 CAVIN1 -2.0 2.43e-68 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000177469 CAVIN1 cancer 20427576
ENSG00000177469 CAVIN1 prostate cancer 20732728
ENSG00000177469 CAVIN1 prostate cancer 22229094
ENSG00000177469 CAVIN1 non-small cell lung cancer 22461895
ENSG00000177469 CAVIN1 prostate cancer 22912783
ENSG00000177469 CAVIN1 breast cancer 23091071
ENSG00000177469 CAVIN1 cancer 23214712
ENSG00000177469 CAVIN1 cancer 23272165
ENSG00000177469 CAVIN1 pancreatic cancer 23770857
ENSG00000177469 CAVIN1 prostate cancer 23934189
ENSG00000177469 CAVIN1 prostate cancer 24123650
ENSG00000177469 CAVIN1 prostate cancer 25018864
ENSG00000177469 CAVIN1 prostate cancer 25520561
ENSG00000177469 CAVIN1 tumors 25822667
ENSG00000177469 CAVIN1 Prostate Cancer 25942420
ENSG00000177469 CAVIN1 pancreatic cancer 26753987
ENSG00000177469 CAVIN1 tumours 27025787
ENSG00000177469 CAVIN1 tumors 27168348
ENSG00000177469 CAVIN1 pancreatic cancer 27174632
ENSG00000177469 CAVIN1 tumor 27384440
ENSG00000177469 CAVIN1 tumor 27894957
ENSG00000177469 CAVIN1 cancer 28498861
ENSG00000177469 CAVIN1 tumors 28865960
ENSG00000177469 CAVIN1 prostate cancer 29899348
ENSG00000177469 CAVIN1 tumor 30311408
ENSG00000177469 CAVIN1 prostate cancer 30759191
ENSG00000177469 CAVIN1 prostate cancer 31285524
ENSG00000177469 CAVIN1 cancer 31607653
ENSG00000177469 CAVIN1 cancer 31862213
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000177469 CAVIN1 SARC 0.0017 low
ENSG00000177469 CAVIN1 STAD 0.0043 high
ENSG00000177469 CAVIN1 UVM 0.037 low
ENSG00000177469 CAVIN1 PAAD 0.008 high
ENSG00000177469 CAVIN1 THCA 0.0043 low
ENSG00000177469 CAVIN1 LUSC 0.022 high
ENSG00000177469 CAVIN1 HNSC 0.0074 high
ENSG00000177469 CAVIN1 READ 0.037 high
ENSG00000177469 CAVIN1 KIRP 0.021 low
ENSG00000177469 CAVIN1 KICH 0.034 low
ENSG00000177469 CAVIN1 LUAD 0.027 high
ENSG00000177469 CAVIN1 COAD 0.0012 high
ENSG00000177469 CAVIN1 ESCA 0.0078 low
ENSG00000177469 CAVIN1 OV 0.00017 high
ENSG00000177469 CAVIN1 DLBC 0.013 low
ENSG00000177469 CAVIN1 KIRC 0.044 low
ENSG00000177469 CAVIN1 TGCT 0.032 high
ENSG00000177469 CAVIN1 BLCA 0.00095 high
ENSG00000177469 CAVIN1 GBM 0.00035 high
ENSG00000177469 CAVIN1 SKCM 0.014 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000177469 CAVIN1 ACC Del 1.947196 0.144353 0.571631 0.277778
ENSG00000177469 CAVIN1 PCPG Del 4.157991 0.119626 0.656331 0.209877
ENSG00000177469 CAVIN1 BRCA Del 6.273836 0.098842 0.429563 0.336111
ENSG00000177469 CAVIN1 PRAD Del 1.650045 0.084279 0.414250 0.128049
ENSG00000177469 CAVIN1 UCEC Del 4.018803 0.081149 0.578466 0.213358