Ensembl ID ENSG00000177192 Gene ID 80324 Accession 15508
Gene Symbol PUS1 Alias MLASA1 Full Name pseudouridine synthase 1
Position 12 : 131929200 - 131945896 Length 16697 bases Strand Plus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary This gene encodes a pseudouridine synthase that converts uridine to pseudouridine once it has been incorporated into an RNA molecule. The encoded enzyme may play an essential role in tRNA function and in stabilizing the secondary and tertiary structure of many RNAs. A mutation in this gene has been linked to mitochondrial myopathy and sideroblastic anemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009]

ENSG00000177192 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000177192 PUS1 0.77 2.30e-23 KIRC
ENSG00000177192 PUS1 0.88 4.71e-34 BRCA
ENSG00000177192 PUS1 1.55 7.18e-44 COAD
ENSG00000177192 PUS1 1.64 1.39e-14 READ
ENSG00000177192 PUS1 1.34 7.23e-48 LUSC
ENSG00000177192 PUS1 0.69 3.91e-16 PRAD
ENSG00000177192 PUS1 0.95 3.08e-19 KIRP
ENSG00000177192 PUS1 0.99 1.12e-19 STAD
ENSG00000177192 PUS1 1.12 7.63e-22 UCEC
ENSG00000177192 PUS1 1.18 3.64e-35 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000177192 PUS1 cancer 30588513
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000177192 PUS1 SARC 0.012 high
ENSG00000177192 PUS1 STAD 0.0022 low
ENSG00000177192 PUS1 UVM 2e-04 high
ENSG00000177192 PUS1 UCEC 0.022 low
ENSG00000177192 PUS1 ACC 0.0022 high
ENSG00000177192 PUS1 LGG 0.00021 high
ENSG00000177192 PUS1 LUSC 0.014 low
ENSG00000177192 PUS1 HNSC 0.014 high
ENSG00000177192 PUS1 READ 0.046 low
ENSG00000177192 PUS1 KIRP 0.0064 high
ENSG00000177192 PUS1 LUAD 0.047 high
ENSG00000177192 PUS1 THYM 0.00095 low
ENSG00000177192 PUS1 ESCA 0.017 high
ENSG00000177192 PUS1 BLCA 0.017 low
ENSG00000177192 PUS1 GBM 0.003 high
ENSG00000177192 PUS1 SKCM 0.0062 high
ENSG00000177192 PUS1 LIHC 2e-04 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000177192 PUS1 LUSC Del 1.126204 0.071961 0.306886 0.177645
ENSG00000177192 PUS1 LUAD Del 2.224441 0.069659 0.289734 0.257752
ENSG00000177192 PUS1 PAAD Del 1.669040 0.064724 0.353293 0.233696
ENSG00000177192 PUS1 SKCM Del 0.972526 0.071095 0.448034 0.228883
ENSG00000177192 PUS1 LIHC Del 3.919676 0.109728 0.466149 0.156757
ENSG00000177192 PUS1 BRCA Del 4.616855 0.090622 0.387591 0.197222
ENSG00000177192 PUS1 PRAD Del 0.621533 0.070636 0.430695 0.089431
ENSG00000177192 PUS1 UCEC Del 2.675750 0.069699 0.394903 0.124304
ENSG00000177192 PUS1 OV Del 10.163718 0.301609 0.571046 0.374784