Ensembl ID ENSG00000177084 Gene ID 5426 Accession 9177
Gene Symbol POLE Alias FILS;POLE1;CRCS12;IMAGEI Full Name DNA polymerase epsilon, catalytic subunit
Position 12 : 132623762 - 132687376 Length 63615 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013]

ENSG00000177084 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000177084 POLE 0.60 2.71e-20 KIRC
ENSG00000177084 POLE 0.69 7.32e-14 HNSC
ENSG00000177084 POLE 0.70 3.22e-37 BRCA
ENSG00000177084 POLE 1.39 3.24e-46 LUSC
ENSG00000177084 POLE 0.77 3.11e-14 KIRP
ENSG00000177084 POLE 0.81 6.13e-13 STAD
ENSG00000177084 POLE 1.16 1.42e-24 UCEC
ENSG00000177084 POLE 2.10 1.06e-15 CESC
ENSG00000177084 POLE 0.97 1.72e-23 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000177084 POLE ovarian cancer 24472300
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000177084 POLE colorectal adenocarcinoma stop_gained 7.912% (180/2275) 3 entries
ENSG00000177084 POLE endometrial carcinoma missense_variant 8.378% (62/740) 10 entries
ENSG00000177084 POLE basal cell carcinoma missense_variant 16.18% (11/68) 2 entries
ENSG00000177084 POLE cecum adenocarcinoma frameshift_variant 12.32% (34/276) 2 entries
ENSG00000177084 POLE colon adenocarcinoma missense_variant 6.855% (107/1561) 12 entries
ENSG00000177084 POLE colon adenocarcinoma stop_gained 6.855% (107/1561) 3 entries
ENSG00000177084 POLE Endometrial Endometrioid Adenocarcinoma sequence_alteration 6.552% (243/3709) 2 entries
ENSG00000177084 POLE cecum adenocarcinoma missense_variant 12.32% (34/276) 6 entries
ENSG00000177084 POLE basal cell carcinoma sequence_alteration 16.18% (11/68) 1 entry
ENSG00000177084 POLE Endometrial Endometrioid Adenocarcinoma frameshift_variant 6.552% (243/3709) 1 entry
ENSG00000177084 POLE colorectal adenocarcinoma sequence_alteration 7.912% (180/2275) 3 entries
ENSG00000177084 POLE colorectal adenocarcinoma conservative_inframe_deletion 7.912% (180/2275) 1 entry
ENSG00000177084 POLE endometrium adenocarcinoma missense_variant 53.54% (53/99) 4 entries
ENSG00000177084 POLE colon adenocarcinoma sequence_alteration 6.855% (107/1561) 6 entries
ENSG00000177084 POLE Ovarian Endometrioid Adenocarcinoma missense_variant 14.1% (32/227) 3 entries
ENSG00000177084 POLE Endometrial Endometrioid Adenocarcinoma missense_variant 6.552% (243/3709) 10 entries
ENSG00000177084 POLE colorectal adenocarcinoma missense_variant 7.912% (180/2275) 14 entries
ENSG00000177084 POLE Endometrial Endometrioid Adenocarcinoma stop_gained 6.552% (243/3709) 3 entries
ENSG00000177084 POLE colorectal adenocarcinoma frameshift_variant 7.912% (180/2275) 3 entries
ENSG00000177084 POLE melanoma missense_variant 13.1% (19/145) 2 entries
ENSG00000177084 POLE melanoma frameshift_variant 13.1% (19/145) 1 entry
ENSG00000177084 POLE cecum adenocarcinoma sequence_alteration 12.32% (34/276) 1 entry
ENSG00000177084 POLE colon adenocarcinoma frameshift_variant 6.855% (107/1561) 4 entries
ENSG00000177084 POLE Endometrial Undifferentiated Carcinoma missense_variant 8.696% (4/46) 3 entries
ENSG00000177084 POLE Uterine Carcinosarcoma sequence_alteration 3.349% (7/209) 1 entry
ENSG00000177084 POLE adrenal cortex carcinoma missense_variant 1.058% (2/189) 1 entry
ENSG00000177084 POLE colorectal adenocarcinoma amino_acid_insertion 7.912% (180/2275) 1 entry
ENSG00000177084 POLE bladder transitional cell carcinoma frameshift_variant 5.97% (28/469) 2 entries
ENSG00000177084 POLE gastric adenocarcinoma stop_gained 3.875% (31/800) 1 entry
ENSG00000177084 POLE prostate adenocarcinoma missense_variant 1.582% (34/2149) 2 entries
ENSG00000177084 POLE lung adenocarcinoma missense_variant 3.073% (78/2538) 5 entries
ENSG00000177084 POLE gastric adenocarcinoma sequence_alteration 3.875% (31/800) 1 entry
ENSG00000177084 POLE Uterine Carcinosarcoma missense_variant 3.349% (7/209) 3 entries
ENSG00000177084 POLE HER2 Positive Breast Carcinoma missense_variant 2.778% (3/108) 2 entries
ENSG00000177084 POLE leiomyosarcoma missense_variant 2.0% (2/100) 1 entry
ENSG00000177084 POLE cervical squamous cell carcinoma missense_variant 2.154% (7/325) 1 entry
ENSG00000177084 POLE HER2 Positive Breast Carcinoma sequence_alteration 2.778% (3/108) 1 entry
ENSG00000177084 POLE acute myeloid leukemia missense_variant 0.7931% (11/1387) 2 entries
ENSG00000177084 POLE rectal adenocarcinoma sequence_alteration 3.551% (25/704) 1 entry
ENSG00000177084 POLE rectal adenocarcinoma frameshift_variant 3.551% (25/704) 1 entry
ENSG00000177084 POLE melanoma sequence_alteration 13.1% (19/145) 1 entry
ENSG00000177084 POLE mucosal melanoma missense_variant 7.143% (5/70) 1 entry
ENSG00000177084 POLE non-small cell lung carcinoma missense_variant 5.319% (10/188) 2 entries
ENSG00000177084 POLE squamous cell lung carcinoma missense_variant 2.897% (27/932) 3 entries
ENSG00000177084 POLE papillary thyroid carcinoma missense_variant 0.818% (4/489) 1 entry
ENSG00000177084 POLE Thyroid Gland Undifferentiated (Anaplastic) Carcinoma missense_variant 1.136% (3/264) 2 entries
ENSG00000177084 POLE head and neck squamous cell carcinoma missense_variant 0.9539% (6/629) 1 entry
ENSG00000177084 POLE rectal adenocarcinoma missense_variant 3.551% (25/704) 5 entries
ENSG00000177084 POLE Ovarian Endometrioid Adenocarcinoma sequence_alteration 14.1% (32/227) 1 entry
ENSG00000177084 POLE brain glioblastoma missense_variant 1.092% (16/1465) 6 entries
ENSG00000177084 POLE pancreatic neuroendocrine tumor stop_gained 2.542% (6/236) 1 entry
ENSG00000177084 POLE diffuse large B-cell lymphoma missense_variant 1.081% (4/370) 3 entries
ENSG00000177084 POLE prostate adenocarcinoma frameshift_variant 1.582% (34/2149) 1 entry
ENSG00000177084 POLE thyroid carcinoma missense_variant 2.808% (26/926) 1 entry
ENSG00000177084 POLE urothelial carcinoma missense_variant 10.47% (9/86) 1 entry
ENSG00000177084 POLE Endometrial Clear Cell Adenocarcinoma missense_variant 3.226% (4/124) 3 entries
ENSG00000177084 POLE gastric adenocarcinoma frameshift_variant 3.875% (31/800) 1 entry
ENSG00000177084 POLE bladder transitional cell carcinoma missense_variant 5.97% (28/469) 4 entries
ENSG00000177084 POLE lung adenocarcinoma stop_gained 3.073% (78/2538) 1 entry
ENSG00000177084 POLE osteosarcoma sequence_alteration 1.316% (2/152) 2 entries
ENSG00000177084 POLE ovarian serous adenocarcinoma missense_variant 0.2169% (2/922) 1 entry
ENSG00000177084 POLE bile duct adenocarcinoma missense_variant 1.12% (7/625) 2 entries
ENSG00000177084 POLE endometrium adenocarcinoma sequence_alteration 53.54% (53/99) 1 entry
ENSG00000177084 POLE gastric intestinal type adenocarcinoma missense_variant 5.882% (5/85) 2 entries
ENSG00000177084 POLE gastric adenocarcinoma missense_variant 3.875% (31/800) 3 entries
ENSG00000177084 POLE breast ductal adenocarcinoma sequence_alteration 2.868% (46/1604) 2 entries
ENSG00000177084 POLE Gallbladder Adenocarcinoma missense_variant 1.031% (2/194) 1 entry
ENSG00000177084 POLE colon adenocarcinoma conservative_inframe_deletion 6.855% (107/1561) 1 entry
ENSG00000177084 POLE small intestinal adenocarcinoma missense_variant 14.29% (3/21) 1 entry
ENSG00000177084 POLE prostate adenocarcinoma sequence_alteration 1.582% (34/2149) 1 entry
ENSG00000177084 POLE breast adenosis missense_variant 16.67% (2/12) 1 entry
ENSG00000177084 POLE breast carcinoma missense_variant 1.062% (16/1506) 4 entries
ENSG00000177084 POLE breast ductal adenocarcinoma missense_variant 2.868% (46/1604) 1 entry
ENSG00000177084 POLE esophageal adenocarcinoma missense_variant 3.473% (19/547) 2 entries
ENSG00000177084 POLE hepatocellular carcinoma missense_variant 1.826% (18/986) 2 entries
ENSG00000177084 POLE oral squamous cell carcinoma missense_variant 3.358% (9/268) 5 entries
ENSG00000177084 POLE Merkel cell skin cancer missense_variant 4.255% (4/94) 2 entries
ENSG00000177084 POLE prostate carcinoma missense_variant 1.408% (6/426) 3 entries
ENSG00000177084 POLE skin melanoma missense_variant 3.534% (41/1160) 6 entries
ENSG00000177084 POLE prostate carcinoma sequence_alteration 1.408% (6/426) 1 entry
ENSG00000177084 POLE dedifferentiated chondrosarcoma missense_variant 12.5% (2/16) 2 entries
ENSG00000177084 POLE small cell lung carcinoma stop_gained 2.935% (13/443) 2 entries
ENSG00000177084 POLE Ovarian Endometrioid Adenocarcinoma stop_gained 14.1% (32/227) 1 entry
ENSG00000177084 POLE Merkel cell skin cancer sequence_alteration 4.255% (4/94) 1 entry
ENSG00000177084 POLE small cell lung carcinoma missense_variant 2.935% (13/443) 4 entries
ENSG00000177084 POLE nasopharyngeal squamous cell carcinoma missense_variant 1.667% (3/180) 2 entries
ENSG00000177084 POLE melanoma stop_gained 13.1% (19/145) 1 entry
ENSG00000177084 POLE anaplastic astrocytoma missense_variant 2.273% (3/132) 3 entries
ENSG00000177084 POLE lung adenocarcinoma sequence_alteration 3.073% (78/2538) 3 entries
ENSG00000177084 POLE lobular breast carcinoma missense_variant 1.695% (4/236) 1 entry
ENSG00000177084 POLE esophageal squamous cell carcinoma missense_variant 1.462% (10/684) 2 entries
ENSG00000177084 POLE pancreatic ductal adenocarcinoma missense_variant 1.604% (27/1683) 3 entries
ENSG00000177084 POLE Brain Stem Glioblastoma conservative_inframe_deletion 1.786% (1/56) 1 entry
ENSG00000177084 POLE pancreatic neuroendocrine tumor missense_variant 2.542% (6/236) 1 entry
ENSG00000177084 POLE adrenal cortex carcinoma sequence_alteration 1.058% (2/189) 1 entry
ENSG00000177084 POLE gastric intestinal type adenocarcinoma sequence_alteration 5.882% (5/85) 1 entry
ENSG00000177084 POLE follicular thyroid carcinoma missense_variant 2.899% (2/69) 1 entry
ENSG00000177084 POLE Ovarian Small Cell Carcinoma missense_variant 33.33% (1/3) 1 entry
ENSG00000177084 POLE B-cell acute lymphoblastic leukemia sequence_alteration 0.9009% (1/111) 1 entry
ENSG00000177084 POLE Invasive Breast Carcinoma frameshift_variant 4.348% (2/46) 1 entry
ENSG00000177084 POLE head and neck squamous cell carcinoma sequence_alteration 0.9539% (6/629) 1 entry
ENSG00000177084 POLE gastric adenocarcinoma conservative_inframe_deletion 3.875% (31/800) 1 entry
ENSG00000177084 POLE papillary renal cell carcinoma missense_variant 0.2584% (1/387) 1 entry
ENSG00000177084 POLE esophageal squamous cell carcinoma sequence_alteration 1.462% (10/684) 1 entry
ENSG00000177084 POLE bronchoalveolar adenocarcinoma sequence_alteration 4.545% (1/22) 1 entry
ENSG00000177084 POLE bile duct adenocarcinoma sequence_alteration 1.12% (7/625) 1 entry
ENSG00000177084 POLE Signet Ring Cell Gastric Adenocarcinoma missense_variant 33.33% (1/3) 1 entry
ENSG00000177084 POLE thyroid carcinoma sequence_alteration 2.808% (26/926) 1 entry
ENSG00000177084 POLE anaplastic oligodendroglioma stop_gained 2.247% (2/89) 1 entry
ENSG00000177084 POLE female breast carcinoma missense_variant 0.3546% (1/282) 1 entry
ENSG00000177084 POLE acute myeloid leukemia frameshift_variant 0.7931% (11/1387) 1 entry
ENSG00000177084 POLE urothelial carcinoma stop_gained 10.47% (9/86) 1 entry
ENSG00000177084 POLE adenosquamous lung carcinoma missense_variant 4.545% (1/22) 1 entry
ENSG00000177084 POLE Invasive Breast Carcinoma missense_variant 4.348% (2/46) 1 entry
ENSG00000177084 POLE colorectal adenoma sequence_alteration 7.143% (1/14) 1 entry
ENSG00000177084 POLE glioma sequence_alteration 0.2793% (2/716) 1 entry
ENSG00000177084 POLE polycythemia vera missense_variant 0.9346% (1/107) 1 entry
ENSG00000177084 POLE follicular thyroid carcinoma sequence_alteration 2.899% (2/69) 1 entry
ENSG00000177084 POLE esophageal adenocarcinoma stop_gained 3.473% (19/547) 1 entry
ENSG00000177084 POLE papillary thyroid carcinoma stop_gained 0.818% (4/489) 1 entry
ENSG00000177084 POLE Extraskeletal Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor missense_variant 3.03% (1/33) 1 entry
ENSG00000177084 POLE Gastrointestinal stromal tumor missense_variant 0.6757% (1/148) 1 entry
ENSG00000177084 POLE Pleural Epithelioid Mesothelioma missense_variant 0.5025% (1/199) 1 entry
ENSG00000177084 POLE Mantle cell lymphoma missense_variant 1.887% (1/53) 1 entry
ENSG00000177084 POLE non-small cell lung carcinoma conservative_inframe_deletion 5.319% (10/188) 1 entry
ENSG00000177084 POLE Central Nervous System Lymphoma missense_variant 11.11% (1/9) 1 entry
ENSG00000177084 POLE metaplastic breast carcinoma sequence_alteration 1.613% (1/62) 1 entry
ENSG00000177084 POLE pancreatic ductal adenocarcinoma stop_gained 1.604% (27/1683) 1 entry
ENSG00000177084 POLE diffuse gastric adenocarcinoma missense_variant 1.22% (1/82) 1 entry
ENSG00000177084 POLE neoplasm missense_variant 3.448% (1/29) 1 entry
ENSG00000177084 POLE nasopharyngeal squamous cell carcinoma sequence_alteration 1.667% (3/180) 1 entry
ENSG00000177084 POLE rectal adenocarcinoma stop_gained 3.551% (25/704) 1 entry
ENSG00000177084 POLE anaplastic oligodendroglioma missense_variant 2.247% (2/89) 1 entry
ENSG00000177084 POLE Uveal Melanoma sequence_alteration 0.7812% (1/128) 1 entry
ENSG00000177084 POLE renal cell carcinoma missense_variant 1.493% (1/67) 1 entry
ENSG00000177084 POLE Endometrial Clear Cell Adenocarcinoma frameshift_variant 3.226% (4/124) 1 entry
ENSG00000177084 POLE lung adenocarcinoma frameshift_variant 3.073% (78/2538) 1 entry
ENSG00000177084 POLE colorectal adenoma missense_variant 7.143% (1/14) 1 entry
ENSG00000177084 POLE adrenocortical adenoma missense_variant 2.439% (1/41) 1 entry
ENSG00000177084 POLE Malignant Germ Cell Tumor missense_variant 100.0% (1/1) 1 entry
ENSG00000177084 POLE Sinonasal Undifferentiated Carcinoma missense_variant 8.333% (1/12) 1 entry
ENSG00000177084 POLE skin carcinoma missense_variant 3.846% (4/104) 1 entry
ENSG00000177084 POLE papillary thyroid carcinoma sequence_alteration 0.818% (4/489) 1 entry
ENSG00000177084 POLE undifferentiated pleomorphic sarcoma missense_variant 1.613% (1/62) 1 entry
ENSG00000177084 POLE ovarian clear cell adenocarcinoma missense_variant 1.316% (1/76) 1 entry
ENSG00000177084 POLE Pleural Mesothelioma missense_variant 0.7042% (1/142) 1 entry
ENSG00000177084 POLE embryonal rhabdomyosarcoma missense_variant 1.163% (1/86) 1 entry
ENSG00000177084 POLE acute lymphoblastic leukemia missense_variant 0.1458% (1/686) 1 entry
ENSG00000177084 POLE brain glioblastoma sequence_alteration 1.092% (16/1465) 1 entry
ENSG00000177084 POLE bile duct adenocarcinoma stop_gained 1.12% (7/625) 1 entry
ENSG00000177084 POLE hemangioblastoma missense_variant 7.692% (1/13) 1 entry
ENSG00000177084 POLE Tracheal Squamous Cell Carcinoma missense_variant 50.0% (1/2) 1 entry
ENSG00000177084 POLE nasal cavity and paranasal sinus carcinoma missense_variant 4.348% (1/23) 1 entry
ENSG00000177084 POLE Mixed Lobular and Ductal Breast Carcinoma missense_variant 1.639% (1/61) 1 entry
ENSG00000177084 POLE multiple myeloma missense_variant 0.8333% (1/120) 1 entry
ENSG00000177084 POLE Prostate Small Cell Carcinoma missense_variant 5.263% (1/19) 1 entry
ENSG00000177084 POLE salivary gland squamous cell carcinoma missense_variant 50.0% (1/2) 1 entry
ENSG00000177084 POLE bladder transitional cell carcinoma sequence_alteration 5.97% (28/469) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000177084 POLE MESO 0.0018 high
ENSG00000177084 POLE SARC 0.0047 high
ENSG00000177084 POLE UVM 0.00071 high
ENSG00000177084 POLE HNSC 0.0017 low
ENSG00000177084 POLE READ 0.038 high
ENSG00000177084 POLE KIRP 0.0045 high
ENSG00000177084 POLE LUAD 0.021 high
ENSG00000177084 POLE PCPG 0.00028 high
ENSG00000177084 POLE UCS 0.015 low
ENSG00000177084 POLE BLCA 0.0055 low
ENSG00000177084 POLE CESC 0.0027 low
ENSG00000177084 POLE LIHC 0.0059 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency