Ensembl ID ENSG00000177084 Gene ID 5426 Accession 9177
Gene Symbol POLE Alias FILS;POLE1;CRCS12;IMAGEI Full Name DNA polymerase epsilon, catalytic subunit
Position 12 : 132623762 - 132687376 Length 63615 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013]

ENSG00000177084 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000177084 0.60 2.71e-20 KIRC
ENSG00000177084 0.69 7.32e-14 HNSC
ENSG00000177084 0.70 3.22e-37 BRCA
ENSG00000177084 1.39 3.24e-46 LUSC
ENSG00000177084 0.77 3.11e-14 KIRP
ENSG00000177084 0.81 6.13e-13 STAD
ENSG00000177084 1.16 1.42e-24 UCEC
ENSG00000177084 2.10 1.06e-15 CESC
ENSG00000177084 0.97 1.72e-23 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000177084 ovarian cancer 24472300
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000177084 colorectal adenocarcinoma stop_gained 7.912% (180/2275) 3 entries
ENSG00000177084 endometrial carcinoma missense_variant 8.378% (62/740) 10 entries
ENSG00000177084 basal cell carcinoma missense_variant 16.18% (11/68) 2 entries
ENSG00000177084 cecum adenocarcinoma frameshift_variant 12.32% (34/276) 2 entries
ENSG00000177084 colon adenocarcinoma missense_variant 6.855% (107/1561) 12 entries
ENSG00000177084 colon adenocarcinoma stop_gained 6.855% (107/1561) 3 entries
ENSG00000177084 Endometrial Endometrioid Adenocarcinoma sequence_alteration 6.552% (243/3709) 2 entries
ENSG00000177084 cecum adenocarcinoma missense_variant 12.32% (34/276) 6 entries
ENSG00000177084 basal cell carcinoma sequence_alteration 16.18% (11/68) 1 entry
ENSG00000177084 Endometrial Endometrioid Adenocarcinoma frameshift_variant 6.552% (243/3709) 1 entry
ENSG00000177084 colorectal adenocarcinoma sequence_alteration 7.912% (180/2275) 3 entries
ENSG00000177084 colorectal adenocarcinoma conservative_inframe_deletion 7.912% (180/2275) 1 entry
ENSG00000177084 endometrium adenocarcinoma missense_variant 53.54% (53/99) 4 entries
ENSG00000177084 colon adenocarcinoma sequence_alteration 6.855% (107/1561) 6 entries
ENSG00000177084 Ovarian Endometrioid Adenocarcinoma missense_variant 14.1% (32/227) 3 entries
ENSG00000177084 Endometrial Endometrioid Adenocarcinoma missense_variant 6.552% (243/3709) 10 entries
ENSG00000177084 colorectal adenocarcinoma missense_variant 7.912% (180/2275) 14 entries
ENSG00000177084 Endometrial Endometrioid Adenocarcinoma stop_gained 6.552% (243/3709) 3 entries
ENSG00000177084 colorectal adenocarcinoma frameshift_variant 7.912% (180/2275) 3 entries
ENSG00000177084 melanoma missense_variant 13.1% (19/145) 2 entries
ENSG00000177084 melanoma frameshift_variant 13.1% (19/145) 1 entry
ENSG00000177084 cecum adenocarcinoma sequence_alteration 12.32% (34/276) 1 entry
ENSG00000177084 colon adenocarcinoma frameshift_variant 6.855% (107/1561) 4 entries
ENSG00000177084 Endometrial Undifferentiated Carcinoma missense_variant 8.696% (4/46) 3 entries
ENSG00000177084 Uterine Carcinosarcoma sequence_alteration 3.349% (7/209) 1 entry
ENSG00000177084 adrenal cortex carcinoma missense_variant 1.058% (2/189) 1 entry
ENSG00000177084 colorectal adenocarcinoma amino_acid_insertion 7.912% (180/2275) 1 entry
ENSG00000177084 bladder transitional cell carcinoma frameshift_variant 5.97% (28/469) 2 entries
ENSG00000177084 gastric adenocarcinoma stop_gained 3.875% (31/800) 1 entry
ENSG00000177084 prostate adenocarcinoma missense_variant 1.582% (34/2149) 2 entries
ENSG00000177084 lung adenocarcinoma missense_variant 3.073% (78/2538) 5 entries
ENSG00000177084 gastric adenocarcinoma sequence_alteration 3.875% (31/800) 1 entry
ENSG00000177084 Uterine Carcinosarcoma missense_variant 3.349% (7/209) 3 entries
ENSG00000177084 HER2 Positive Breast Carcinoma missense_variant 2.778% (3/108) 2 entries
ENSG00000177084 leiomyosarcoma missense_variant 2.0% (2/100) 1 entry
ENSG00000177084 cervical squamous cell carcinoma missense_variant 2.154% (7/325) 1 entry
ENSG00000177084 HER2 Positive Breast Carcinoma sequence_alteration 2.778% (3/108) 1 entry
ENSG00000177084 acute myeloid leukemia missense_variant 0.7931% (11/1387) 2 entries
ENSG00000177084 rectal adenocarcinoma sequence_alteration 3.551% (25/704) 1 entry
ENSG00000177084 rectal adenocarcinoma frameshift_variant 3.551% (25/704) 1 entry
ENSG00000177084 melanoma sequence_alteration 13.1% (19/145) 1 entry
ENSG00000177084 mucosal melanoma missense_variant 7.143% (5/70) 1 entry
ENSG00000177084 non-small cell lung carcinoma missense_variant 5.319% (10/188) 2 entries
ENSG00000177084 squamous cell lung carcinoma missense_variant 2.897% (27/932) 3 entries
ENSG00000177084 papillary thyroid carcinoma missense_variant 0.818% (4/489) 1 entry
ENSG00000177084 Thyroid Gland Undifferentiated (Anaplastic) Carcinoma missense_variant 1.136% (3/264) 2 entries
ENSG00000177084 head and neck squamous cell carcinoma missense_variant 0.9539% (6/629) 1 entry
ENSG00000177084 rectal adenocarcinoma missense_variant 3.551% (25/704) 5 entries
ENSG00000177084 Ovarian Endometrioid Adenocarcinoma sequence_alteration 14.1% (32/227) 1 entry
ENSG00000177084 brain glioblastoma missense_variant 1.092% (16/1465) 6 entries
ENSG00000177084 pancreatic neuroendocrine tumor stop_gained 2.542% (6/236) 1 entry
ENSG00000177084 diffuse large B-cell lymphoma missense_variant 1.081% (4/370) 3 entries
ENSG00000177084 prostate adenocarcinoma frameshift_variant 1.582% (34/2149) 1 entry
ENSG00000177084 thyroid carcinoma missense_variant 2.808% (26/926) 1 entry
ENSG00000177084 urothelial carcinoma missense_variant 10.47% (9/86) 1 entry
ENSG00000177084 Endometrial Clear Cell Adenocarcinoma missense_variant 3.226% (4/124) 3 entries
ENSG00000177084 gastric adenocarcinoma frameshift_variant 3.875% (31/800) 1 entry
ENSG00000177084 bladder transitional cell carcinoma missense_variant 5.97% (28/469) 4 entries
ENSG00000177084 lung adenocarcinoma stop_gained 3.073% (78/2538) 1 entry
ENSG00000177084 osteosarcoma sequence_alteration 1.316% (2/152) 2 entries
ENSG00000177084 ovarian serous adenocarcinoma missense_variant 0.2169% (2/922) 1 entry
ENSG00000177084 bile duct adenocarcinoma missense_variant 1.12% (7/625) 2 entries
ENSG00000177084 endometrium adenocarcinoma sequence_alteration 53.54% (53/99) 1 entry
ENSG00000177084 gastric intestinal type adenocarcinoma missense_variant 5.882% (5/85) 2 entries
ENSG00000177084 gastric adenocarcinoma missense_variant 3.875% (31/800) 3 entries
ENSG00000177084 breast ductal adenocarcinoma sequence_alteration 2.868% (46/1604) 2 entries
ENSG00000177084 Gallbladder Adenocarcinoma missense_variant 1.031% (2/194) 1 entry
ENSG00000177084 colon adenocarcinoma conservative_inframe_deletion 6.855% (107/1561) 1 entry
ENSG00000177084 small intestinal adenocarcinoma missense_variant 14.29% (3/21) 1 entry
ENSG00000177084 prostate adenocarcinoma sequence_alteration 1.582% (34/2149) 1 entry
ENSG00000177084 breast adenosis missense_variant 16.67% (2/12) 1 entry
ENSG00000177084 breast carcinoma missense_variant 1.062% (16/1506) 4 entries
ENSG00000177084 breast ductal adenocarcinoma missense_variant 2.868% (46/1604) 1 entry
ENSG00000177084 esophageal adenocarcinoma missense_variant 3.473% (19/547) 2 entries
ENSG00000177084 hepatocellular carcinoma missense_variant 1.826% (18/986) 2 entries
ENSG00000177084 oral squamous cell carcinoma missense_variant 3.358% (9/268) 5 entries
ENSG00000177084 Merkel cell skin cancer missense_variant 4.255% (4/94) 2 entries
ENSG00000177084 prostate carcinoma missense_variant 1.408% (6/426) 3 entries
ENSG00000177084 skin melanoma missense_variant 3.534% (41/1160) 6 entries
ENSG00000177084 prostate carcinoma sequence_alteration 1.408% (6/426) 1 entry
ENSG00000177084 dedifferentiated chondrosarcoma missense_variant 12.5% (2/16) 2 entries
ENSG00000177084 small cell lung carcinoma stop_gained 2.935% (13/443) 2 entries
ENSG00000177084 Ovarian Endometrioid Adenocarcinoma stop_gained 14.1% (32/227) 1 entry
ENSG00000177084 Merkel cell skin cancer sequence_alteration 4.255% (4/94) 1 entry
ENSG00000177084 small cell lung carcinoma missense_variant 2.935% (13/443) 4 entries
ENSG00000177084 nasopharyngeal squamous cell carcinoma missense_variant 1.667% (3/180) 2 entries
ENSG00000177084 melanoma stop_gained 13.1% (19/145) 1 entry
ENSG00000177084 anaplastic astrocytoma missense_variant 2.273% (3/132) 3 entries
ENSG00000177084 lung adenocarcinoma sequence_alteration 3.073% (78/2538) 3 entries
ENSG00000177084 lobular breast carcinoma missense_variant 1.695% (4/236) 1 entry
ENSG00000177084 esophageal squamous cell carcinoma missense_variant 1.462% (10/684) 2 entries
ENSG00000177084 pancreatic ductal adenocarcinoma missense_variant 1.604% (27/1683) 3 entries
ENSG00000177084 Brain Stem Glioblastoma conservative_inframe_deletion 1.786% (1/56) 1 entry
ENSG00000177084 pancreatic neuroendocrine tumor missense_variant 2.542% (6/236) 1 entry
ENSG00000177084 adrenal cortex carcinoma sequence_alteration 1.058% (2/189) 1 entry
ENSG00000177084 gastric intestinal type adenocarcinoma sequence_alteration 5.882% (5/85) 1 entry
ENSG00000177084 follicular thyroid carcinoma missense_variant 2.899% (2/69) 1 entry
ENSG00000177084 Ovarian Small Cell Carcinoma missense_variant 33.33% (1/3) 1 entry
ENSG00000177084 B-cell acute lymphoblastic leukemia sequence_alteration 0.9009% (1/111) 1 entry
ENSG00000177084 Invasive Breast Carcinoma frameshift_variant 4.348% (2/46) 1 entry
ENSG00000177084 head and neck squamous cell carcinoma sequence_alteration 0.9539% (6/629) 1 entry
ENSG00000177084 gastric adenocarcinoma conservative_inframe_deletion 3.875% (31/800) 1 entry
ENSG00000177084 papillary renal cell carcinoma missense_variant 0.2584% (1/387) 1 entry
ENSG00000177084 esophageal squamous cell carcinoma sequence_alteration 1.462% (10/684) 1 entry
ENSG00000177084 bronchoalveolar adenocarcinoma sequence_alteration 4.545% (1/22) 1 entry
ENSG00000177084 bile duct adenocarcinoma sequence_alteration 1.12% (7/625) 1 entry
ENSG00000177084 Signet Ring Cell Gastric Adenocarcinoma missense_variant 33.33% (1/3) 1 entry
ENSG00000177084 thyroid carcinoma sequence_alteration 2.808% (26/926) 1 entry
ENSG00000177084 anaplastic oligodendroglioma stop_gained 2.247% (2/89) 1 entry
ENSG00000177084 female breast carcinoma missense_variant 0.3546% (1/282) 1 entry
ENSG00000177084 acute myeloid leukemia frameshift_variant 0.7931% (11/1387) 1 entry
ENSG00000177084 urothelial carcinoma stop_gained 10.47% (9/86) 1 entry
ENSG00000177084 adenosquamous lung carcinoma missense_variant 4.545% (1/22) 1 entry
ENSG00000177084 Invasive Breast Carcinoma missense_variant 4.348% (2/46) 1 entry
ENSG00000177084 colorectal adenoma sequence_alteration 7.143% (1/14) 1 entry
ENSG00000177084 glioma sequence_alteration 0.2793% (2/716) 1 entry
ENSG00000177084 polycythemia vera missense_variant 0.9346% (1/107) 1 entry
ENSG00000177084 follicular thyroid carcinoma sequence_alteration 2.899% (2/69) 1 entry
ENSG00000177084 esophageal adenocarcinoma stop_gained 3.473% (19/547) 1 entry
ENSG00000177084 papillary thyroid carcinoma stop_gained 0.818% (4/489) 1 entry
ENSG00000177084 Extraskeletal Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor missense_variant 3.03% (1/33) 1 entry
ENSG00000177084 Gastrointestinal stromal tumor missense_variant 0.6757% (1/148) 1 entry
ENSG00000177084 Pleural Epithelioid Mesothelioma missense_variant 0.5025% (1/199) 1 entry
ENSG00000177084 Mantle cell lymphoma missense_variant 1.887% (1/53) 1 entry
ENSG00000177084 non-small cell lung carcinoma conservative_inframe_deletion 5.319% (10/188) 1 entry
ENSG00000177084 Central Nervous System Lymphoma missense_variant 11.11% (1/9) 1 entry
ENSG00000177084 metaplastic breast carcinoma sequence_alteration 1.613% (1/62) 1 entry
ENSG00000177084 pancreatic ductal adenocarcinoma stop_gained 1.604% (27/1683) 1 entry
ENSG00000177084 diffuse gastric adenocarcinoma missense_variant 1.22% (1/82) 1 entry
ENSG00000177084 neoplasm missense_variant 3.448% (1/29) 1 entry
ENSG00000177084 nasopharyngeal squamous cell carcinoma sequence_alteration 1.667% (3/180) 1 entry
ENSG00000177084 rectal adenocarcinoma stop_gained 3.551% (25/704) 1 entry
ENSG00000177084 anaplastic oligodendroglioma missense_variant 2.247% (2/89) 1 entry
ENSG00000177084 Uveal Melanoma sequence_alteration 0.7812% (1/128) 1 entry
ENSG00000177084 renal cell carcinoma missense_variant 1.493% (1/67) 1 entry
ENSG00000177084 Endometrial Clear Cell Adenocarcinoma frameshift_variant 3.226% (4/124) 1 entry
ENSG00000177084 lung adenocarcinoma frameshift_variant 3.073% (78/2538) 1 entry
ENSG00000177084 colorectal adenoma missense_variant 7.143% (1/14) 1 entry
ENSG00000177084 adrenocortical adenoma missense_variant 2.439% (1/41) 1 entry
ENSG00000177084 Malignant Germ Cell Tumor missense_variant 100.0% (1/1) 1 entry
ENSG00000177084 Sinonasal Undifferentiated Carcinoma missense_variant 8.333% (1/12) 1 entry
ENSG00000177084 skin carcinoma missense_variant 3.846% (4/104) 1 entry
ENSG00000177084 papillary thyroid carcinoma sequence_alteration 0.818% (4/489) 1 entry
ENSG00000177084 undifferentiated pleomorphic sarcoma missense_variant 1.613% (1/62) 1 entry
ENSG00000177084 ovarian clear cell adenocarcinoma missense_variant 1.316% (1/76) 1 entry
ENSG00000177084 Pleural Mesothelioma missense_variant 0.7042% (1/142) 1 entry
ENSG00000177084 embryonal rhabdomyosarcoma missense_variant 1.163% (1/86) 1 entry
ENSG00000177084 acute lymphoblastic leukemia missense_variant 0.1458% (1/686) 1 entry
ENSG00000177084 brain glioblastoma sequence_alteration 1.092% (16/1465) 1 entry
ENSG00000177084 bile duct adenocarcinoma stop_gained 1.12% (7/625) 1 entry
ENSG00000177084 hemangioblastoma missense_variant 7.692% (1/13) 1 entry
ENSG00000177084 Tracheal Squamous Cell Carcinoma missense_variant 50.0% (1/2) 1 entry
ENSG00000177084 nasal cavity and paranasal sinus carcinoma missense_variant 4.348% (1/23) 1 entry
ENSG00000177084 Mixed Lobular and Ductal Breast Carcinoma missense_variant 1.639% (1/61) 1 entry
ENSG00000177084 multiple myeloma missense_variant 0.8333% (1/120) 1 entry
ENSG00000177084 Prostate Small Cell Carcinoma missense_variant 5.263% (1/19) 1 entry
ENSG00000177084 salivary gland squamous cell carcinoma missense_variant 50.0% (1/2) 1 entry
ENSG00000177084 bladder transitional cell carcinoma sequence_alteration 5.97% (28/469) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000177084 MESO 0.0018 high
ENSG00000177084 SARC 0.0047 high
ENSG00000177084 UVM 0.00071 high
ENSG00000177084 HNSC 0.0017 low
ENSG00000177084 READ 0.038 high
ENSG00000177084 KIRP 0.0045 high
ENSG00000177084 LUAD 0.021 high
ENSG00000177084 PCPG 0.00028 high
ENSG00000177084 UCS 0.015 low
ENSG00000177084 BLCA 0.0055 low
ENSG00000177084 CESC 0.0027 low
ENSG00000177084 LIHC 0.0059 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency