Ensembl ID ENSG00000176444 Gene ID 1196 Accession 2069
Gene Symbol CLK2 Alias NA Full Name CDC like kinase 2
Position 1 : 155262868 - 155273504 Length 10637 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Non-canonical_RBPs
Summary This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

ENSG00000176444 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000176444 CLK2 1.04 9.71e-34 KIRC
ENSG00000176444 CLK2 0.95 3.10e-11 BLCA
ENSG00000176444 CLK2 0.55 3.18e-26 BRCA
ENSG00000176444 CLK2 0.64 3.74e-15 COAD
ENSG00000176444 CLK2 0.87 3.91e-27 LUSC
ENSG00000176444 CLK2 0.80 8.06e-12 KIRP
ENSG00000176444 CLK2 1.02 1.17e-32 LIHC
ENSG00000176444 CLK2 1.01 2.36e-37 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000176444 CLK2 Breast Cancer 25670169
ENSG00000176444 CLK2 breast cancer 26098145
ENSG00000176444 CLK2 tumor 27004405
ENSG00000176444 CLK2 tumors 27015110
ENSG00000176444 CLK2 tumors 27050366
ENSG00000176444 CLK2 prostate cancer 28289210
ENSG00000176444 CLK2 Triple Negative Breast Cancer 28991472
ENSG00000176444 CLK2 breast cancer 29606096
ENSG00000176444 CLK2 cancer 29769258
ENSG00000176444 CLK2 breast tumors 29789342
ENSG00000176444 CLK2 breast cancer 29866747
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000176444 CLK2 SARC 0.012 high
ENSG00000176444 CLK2 UVM 0.00085 high
ENSG00000176444 CLK2 UCEC 0.014 low
ENSG00000176444 CLK2 THCA 0.014 low
ENSG00000176444 CLK2 HNSC 0.022 high
ENSG00000176444 CLK2 KIRP 0.02 high
ENSG00000176444 CLK2 PCPG 0.042 high
ENSG00000176444 CLK2 BRCA 0.027 low
ENSG00000176444 CLK2 COAD 6e-04 high
ENSG00000176444 CLK2 ESCA 0.036 high
ENSG00000176444 CLK2 OV 0.028 low
ENSG00000176444 CLK2 BLCA 0.0013 low
ENSG00000176444 CLK2 LAML 0.02 high
ENSG00000176444 CLK2 GBM 0.049 low
ENSG00000176444 CLK2 CESC 0.0068 high
ENSG00000176444 CLK2 LIHC 6e-04 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000176444 CLK2 CHOL Amp 1.885082 0.646268 1.042664 0.666667
ENSG00000176444 CLK2 LUSC Amp 3.420042 0.271903 0.551632 0.526946
ENSG00000176444 CLK2 LUAD Amp 19.780578 0.393010 0.604870 0.740310
ENSG00000176444 CLK2 CESC Amp 2.753429 0.203975 0.620008 0.535593
ENSG00000176444 CLK2 UCS Amp 4.555869 1.025630 1.020787 0.696429
ENSG00000176444 CLK2 SARC Amp 3.154935 0.380641 0.698008 0.373541
ENSG00000176444 CLK2 GBM Amp 1.168574 0.076650 0.526668 0.185442
ENSG00000176444 CLK2 PAAD Amp 0.922175 0.089452 0.432459 0.331522
ENSG00000176444 CLK2 SKCM Amp 3.324142 0.198681 0.685198 0.550409
ENSG00000176444 CLK2 LIHC Amp 19.036324 0.413651 0.906510 0.759459
ENSG00000176444 CLK2 PCPG Amp 0.826699 0.073359 0.649498 0.160494
ENSG00000176444 CLK2 DLBC Amp 1.306895 0.247389 0.653875 0.250000
ENSG00000176444 CLK2 BLCA Amp 8.089579 0.353552 0.580154 0.448529
ENSG00000176444 CLK2 BRCA Amp 24.924833 0.385966 0.801510 0.736111
ENSG00000176444 CLK2 STAD Amp 1.760958 0.163479 0.452346 0.362812
ENSG00000176444 CLK2 PRAD Amp 3.108938 0.078539 0.658816 0.079268
ENSG00000176444 CLK2 UCEC Amp 12.501773 0.274804 0.872199 0.469388
ENSG00000176444 CLK2 OV Amp 13.595079 0.604850 0.751952 0.621762