Ensembl ID ENSG00000175467 Gene ID 9092 Accession 10538
Gene Symbol SART1 Alias HAF;Ara1;HOMS1;Snu66;SART1259;SNRNP110 Full Name spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
Position 11 : 65961729 - 65980137 Length 18409 bases Strand Plus strand
Status Confidence Main interacting RNAssnRNARBP type Canonical_RBPs
Summary This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]

ENSG00000175467 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000175467 SART1 0.77 1.28e-14 KICH
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000175467 SART1 tumor 10081490
ENSG00000175467 SART1 tumor 10209962
ENSG00000175467 SART1 tumor 10551332
ENSG00000175467 SART1 brain tumors 10597192
ENSG00000175467 SART1 tumor 10838658
ENSG00000175467 SART1 tumor 10853014
ENSG00000175467 SART1 tumor 10929426
ENSG00000175467 SART1 cancer 11015990
ENSG00000175467 SART1 cancer 11092984
ENSG00000175467 SART1 colorectal cancers 11156463
ENSG00000175467 SART1 tumor 11182058
ENSG00000175467 SART1 cancer 11993228
ENSG00000175467 SART1 tumor 12733146
ENSG00000175467 SART1 tumor 14696095
ENSG00000175467 SART1 malignant brain tumors 15514588
ENSG00000175467 SART1 cancer 16158934
ENSG00000175467 SART1 tumor 19058036
ENSG00000175467 SART1 cancer 19122400
ENSG00000175467 SART1 breast cancer 19377877
ENSG00000175467 SART1 breast cancer 21695249
ENSG00000175467 SART1 colorectal cancer 22027693
ENSG00000175467 SART1 cancers 24556687
ENSG00000175467 SART1 esophageal cancer 25625346
ENSG00000175467 SART1 tumor 26799785
ENSG00000175467 SART1 tumor 9449708
ENSG00000175467 SART1 tumor 9765622
ENSG00000175467 SART1 breast cancer 9935232
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000175467 SART1 STAD 0.037 low
ENSG00000175467 SART1 PAAD 0.019 high
ENSG00000175467 SART1 LGG 0.0042 low
ENSG00000175467 SART1 READ 0.022 low
ENSG00000175467 SART1 KIRP 0.023 high
ENSG00000175467 SART1 KICH 0.046 high
ENSG00000175467 SART1 LUAD 0.048 high
ENSG00000175467 SART1 THYM 0.0049 low
ENSG00000175467 SART1 BRCA 0.036 low
ENSG00000175467 SART1 COAD 0.008 high
ENSG00000175467 SART1 DLBC 0.0048 low
ENSG00000175467 SART1 KIRC 0.0015 high
ENSG00000175467 SART1 PRAD 0.041 low
ENSG00000175467 SART1 LAML 0.0016 high
ENSG00000175467 SART1 GBM 0.034 high
ENSG00000175467 SART1 SKCM 0.01 low
ENSG00000175467 SART1 CESC 0.0076 low
ENSG00000175467 SART1 LIHC 0.0091 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000175467 SART1 CESC Amp 0.807001 0.132513 0.516431 0.118644
ENSG00000175467 SART1 HNSC Amp 12.160024 0.307023 0.520988 0.323755
ENSG00000175467 SART1 BLCA Amp 0.926894 0.172626 0.447137 0.240196
ENSG00000175467 SART1 BRCA Amp 0.709054 0.145367 0.481324 0.203704
ENSG00000175467 SART1 PRAD Amp 3.357046 0.081684 0.547943 0.093496