Ensembl ID ENSG00000175216 Gene ID 9793 Accession 28959
Gene Symbol CKAP5 Alias TOG;MSPS;TOGp;CHTOG;ch-TOG Full Name cytoskeleton associated protein 5
Position 11 : 46743048 - 46846308 Length 103261 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

ENSG00000175216 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000175216 CKAP5 0.78 6.59e-39 BRCA
ENSG00000175216 CKAP5 0.77 5.17e-30 COAD
ENSG00000175216 CKAP5 0.99 7.61e-27 KICH
ENSG00000175216 CKAP5 1.14 1.05e-38 LUSC
ENSG00000175216 CKAP5 0.91 7.29e-20 STAD
ENSG00000175216 CKAP5 0.69 5.97e-12 UCEC
ENSG00000175216 CKAP5 0.78 4.75e-22 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000175216 CKAP5 tumors 11093249
ENSG00000175216 CKAP5 tumour 11903063
ENSG00000175216 CKAP5 cancer 12569123
ENSG00000175216 CKAP5 breast cancer 14603251
ENSG00000175216 CKAP5 tumor 17634360
ENSG00000175216 CKAP5 tumor 18663358
ENSG00000175216 CKAP5 cancer 20838383
ENSG00000175216 CKAP5 tumour 21297582
ENSG00000175216 CKAP5 Tumors 21647268
ENSG00000175216 CKAP5 tumor 21922039
ENSG00000175216 CKAP5 tumour 22294613
ENSG00000175216 CKAP5 tumor 22891263
ENSG00000175216 CKAP5 tumor 23444224
ENSG00000175216 CKAP5 tumor 23918938
ENSG00000175216 CKAP5 cancer 24273164
ENSG00000175216 CKAP5 tumor 25596274
ENSG00000175216 CKAP5 cancer 26154152
ENSG00000175216 CKAP5 cancer 26497677
ENSG00000175216 CKAP5 cancer 27102297
ENSG00000175216 CKAP5 tumor 27152245
ENSG00000175216 CKAP5 non-small cell lung cancer 28101582
ENSG00000175216 CKAP5 tumor 28177917
ENSG00000175216 CKAP5 liver cancer 29250165
ENSG00000175216 CKAP5 tumor 29582386
ENSG00000175216 CKAP5 Tumour 29757235
ENSG00000175216 CKAP5 tumors 30305138
ENSG00000175216 CKAP5 tumor 30647854
ENSG00000175216 CKAP5 tumor 8536682
ENSG00000175216 CKAP5 tumor 8832653
ENSG00000175216 CKAP5 tumors 9570755
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000175216 CKAP5 SARC 0.0083 high
ENSG00000175216 CKAP5 CHOL 0.035 high
ENSG00000175216 CKAP5 UVM 0.046 high
ENSG00000175216 CKAP5 PAAD 0.0052 high
ENSG00000175216 CKAP5 UCEC 0.035 low
ENSG00000175216 CKAP5 ACC 0.0016 high
ENSG00000175216 CKAP5 HNSC 0.01 high
ENSG00000175216 CKAP5 READ 0.045 low
ENSG00000175216 CKAP5 KIRP 0.00073 high
ENSG00000175216 CKAP5 LUAD 0.021 high
ENSG00000175216 CKAP5 PCPG 0.0069 low
ENSG00000175216 CKAP5 THYM 0.0016 low
ENSG00000175216 CKAP5 UCS 0.043 low
ENSG00000175216 CKAP5 OV 0.047 low
ENSG00000175216 CKAP5 KIRC 0.0095 low
ENSG00000175216 CKAP5 PRAD 0.023 high
ENSG00000175216 CKAP5 BLCA 0.027 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000175216 CKAP5 PRAD Del 1.382429 0.080979 0.557301 0.067073