Ensembl ID ENSG00000175198 Gene ID 5095 Accession 8653
Gene Symbol PCCA Alias NA Full Name propionyl-CoA carboxylase subunit alpha
Position 13 : 100089015 - 100530437 Length 441423 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

ENSG00000175198 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000175198 PCCA -1.4 9.54e-52 KIRC
ENSG00000175198 PCCA -1.1 9.90e-29 HNSC
ENSG00000175198 PCCA -1.0 3.45e-50 BRCA
ENSG00000175198 PCCA -0.9 3.87e-14 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000175198 PCCA colorectal cancers 27468871
ENSG00000175198 PCCA breast cancer 27686582
ENSG00000175198 PCCA tumors 28127427
ENSG00000175198 PCCA tumor 30213222
ENSG00000175198 PCCA breast cancer 30228045
ENSG00000175198 PCCA tumor 30988817
ENSG00000175198 PCCA colorectal cancers 9311592
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000175198 PCCA MESO 0.001 low
ENSG00000175198 PCCA UVM 0.035 low
ENSG00000175198 PCCA UCEC 0.045 low
ENSG00000175198 PCCA THCA 0.015 high
ENSG00000175198 PCCA LUSC 0.037 high
ENSG00000175198 PCCA HNSC 0.014 low
ENSG00000175198 PCCA READ 0.03 high
ENSG00000175198 PCCA KICH 0.013 low
ENSG00000175198 PCCA LUAD 0.0044 low
ENSG00000175198 PCCA PCPG 0.012 high
ENSG00000175198 PCCA THYM 0.0034 low
ENSG00000175198 PCCA COAD 0.0031 low
ENSG00000175198 PCCA DLBC 0.023 high
ENSG00000175198 PCCA GBM 0.0068 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000175198 PCCA CESC Amp 2.145516 0.184098 0.549077 0.210169
ENSG00000175198 PCCA READ Amp 1.361515 0.159283 1.024963 0.696970
ENSG00000175198 PCCA COAD Amp 4.030257 0.125336 0.910597 0.578714
ENSG00000175198 PCCA UCS Amp 0.739240 0.499316 0.900554 0.410714
ENSG00000175198 PCCA SARC Del 1.024795 0.131435 0.587535 0.455253
ENSG00000175198 PCCA LIHC Amp 8.316551 0.263312 0.819109 0.175676
ENSG00000175198 PCCA BLCA Amp 0.771550 0.166576 0.483794 0.333333
ENSG00000175198 PCCA BRCA Amp 0.759385 0.146553 0.591258 0.154630