Ensembl ID ENSG00000175198 Gene ID 5095 Accession 8653
Gene Symbol PCCA Alias NA Full Name propionyl-CoA carboxylase subunit alpha
Position 13 : 100089015 - 100530437 Length 441423 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

ENSG00000175198 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000175198 -1.4 9.54e-52 KIRC
ENSG00000175198 -1.1 9.90e-29 HNSC
ENSG00000175198 -1.0 3.45e-50 BRCA
ENSG00000175198 -0.9 3.87e-14 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000175198 colorectal cancers 27468871
ENSG00000175198 breast cancer 27686582
ENSG00000175198 tumors 28127427
ENSG00000175198 tumor 30213222
ENSG00000175198 breast cancer 30228045
ENSG00000175198 tumor 30988817
ENSG00000175198 colorectal cancers 9311592
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000175198 MESO 0.001 low
ENSG00000175198 UVM 0.035 low
ENSG00000175198 UCEC 0.045 low
ENSG00000175198 THCA 0.015 high
ENSG00000175198 LUSC 0.037 high
ENSG00000175198 HNSC 0.014 low
ENSG00000175198 READ 0.03 high
ENSG00000175198 KICH 0.013 low
ENSG00000175198 LUAD 0.0044 low
ENSG00000175198 PCPG 0.012 high
ENSG00000175198 THYM 0.0034 low
ENSG00000175198 COAD 0.0031 low
ENSG00000175198 DLBC 0.023 high
ENSG00000175198 GBM 0.0068 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000175198 CESC Amp 2.145516 0.184098 0.549077 0.210169
ENSG00000175198 READ Amp 1.361515 0.159283 1.024963 0.696970
ENSG00000175198 COAD Amp 4.030257 0.125336 0.910597 0.578714
ENSG00000175198 UCS Amp 0.739240 0.499316 0.900554 0.410714
ENSG00000175198 SARC Del 1.024795 0.131435 0.587535 0.455253
ENSG00000175198 LIHC Amp 8.316551 0.263312 0.819109 0.175676
ENSG00000175198 BLCA Amp 0.771550 0.166576 0.483794 0.333333
ENSG00000175198 BRCA Amp 0.759385 0.146553 0.591258 0.154630