Ensembl ID ENSG00000175054 Gene ID 545 Accession 882
Gene Symbol ATR Alias FRP1;MEC1;SCKL;FCTCS;SCKL1 Full Name ATR serine/threonine kinase
Position 3 : 142449235 - 142578733 Length 129499 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]

ENSG00000175054 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000175054 ATR 0.92 4.89e-21 COAD
ENSG00000175054 ATR 0.96 2.11e-31 LUSC
ENSG00000175054 ATR 1.05 3.36e-20 STAD
ENSG00000175054 ATR 0.61 5.19e-14 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000175054 ATR breast cancer 21849621
ENSG00000175054 ATR colon cancer 23566654
ENSG00000175054 ATR tumor 25253693
ENSG00000175054 ATR breast cancer 26680552
ENSG00000175054 ATR cancer 27823879
ENSG00000175054 ATR breast cancer 28721278
ENSG00000175054 ATR tumor 29038346
ENSG00000175054 ATR cancer 29685176
ENSG00000175054 ATR tumor 29740495
ENSG00000175054 ATR cancer 29899559
ENSG00000175054 ATR tumor 31092378
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000175054 ATR colorectal adenocarcinoma stop_gained 6.662% (95/1426) 3 entries
ENSG00000175054 ATR hemangioblastoma sequence_alteration 40.0% (14/35) 1 entry
ENSG00000175054 ATR breast ductal adenocarcinoma stop_gained 5.501% (96/1745) 2 entries
ENSG00000175054 ATR Ovarian Endometrioid Adenocarcinoma sequence_alteration 33.33% (6/18) 1 entry
ENSG00000175054 ATR breast ductal adenocarcinoma missense_variant 5.501% (96/1745) 4 entries
ENSG00000175054 ATR breast ductal adenocarcinoma conservative_inframe_deletion 5.501% (96/1745) 1 entry
ENSG00000175054 ATR breast ductal adenocarcinoma frameshift_variant 5.501% (96/1745) 1 entry
ENSG00000175054 ATR colorectal adenocarcinoma sequence_alteration 6.662% (95/1426) 3 entries
ENSG00000175054 ATR colorectal adenocarcinoma frameshift_variant 6.662% (95/1426) 4 entries
ENSG00000175054 ATR Ovarian Endometrioid Adenocarcinoma missense_variant 33.33% (6/18) 1 entry
ENSG00000175054 ATR colorectal adenocarcinoma missense_variant 6.662% (95/1426) 7 entries
ENSG00000175054 ATR breast carcinoma missense_variant 1.579% (26/1647) 2 entries
ENSG00000175054 ATR lung adenocarcinoma missense_variant 2.823% (78/2763) 6 entries
ENSG00000175054 ATR Merkel cell skin cancer missense_variant 3.191% (3/94) 2 entries
ENSG00000175054 ATR urothelial carcinoma missense_variant 8.14% (7/86) 1 entry
ENSG00000175054 ATR small cell lung carcinoma missense_variant 4.289% (19/443) 4 entries
ENSG00000175054 ATR Mixed Lobular and Ductal Breast Carcinoma missense_variant 2.778% (2/72) 1 entry
ENSG00000175054 ATR skin melanoma missense_variant 4.655% (54/1160) 9 entries
ENSG00000175054 ATR esophageal squamous cell carcinoma frameshift_variant 1.608% (11/684) 2 entries
ENSG00000175054 ATR prostate adenocarcinoma missense_variant 3.517% (76/2161) 2 entries
ENSG00000175054 ATR oral squamous cell carcinoma stop_gained 1.901% (5/263) 2 entries
ENSG00000175054 ATR basal cell carcinoma missense_variant 11.76% (8/68) 1 entry
ENSG00000175054 ATR cervical squamous cell carcinoma missense_variant 2.462% (8/325) 1 entry
ENSG00000175054 ATR esophageal adenocarcinoma missense_variant 6.216% (34/547) 2 entries
ENSG00000175054 ATR rectal adenocarcinoma missense_variant 2.364% (13/550) 3 entries
ENSG00000175054 ATR colon adenocarcinoma stop_gained 3.793% (49/1292) 4 entries
ENSG00000175054 ATR breast carcinoma stop_gained 1.579% (26/1647) 3 entries
ENSG00000175054 ATR papillary renal cell carcinoma missense_variant 1.538% (6/390) 2 entries
ENSG00000175054 ATR chronic myelomonocytic leukemia missense_variant 3.158% (3/95) 1 entry
ENSG00000175054 ATR bladder transitional cell carcinoma stop_gained 6.1% (28/459) 1 entry
ENSG00000175054 ATR Uterine Carcinosarcoma missense_variant 6.667% (11/165) 1 entry
ENSG00000175054 ATR colon adenocarcinoma sequence_alteration 3.793% (49/1292) 3 entries
ENSG00000175054 ATR bile duct adenocarcinoma missense_variant 2.08% (13/625) 2 entries
ENSG00000175054 ATR Gallbladder Adenocarcinoma missense_variant 4.124% (8/194) 2 entries
ENSG00000175054 ATR cecum adenocarcinoma missense_variant 4.833% (13/269) 3 entries
ENSG00000175054 ATR female breast carcinoma missense_variant 2.482% (7/282) 2 entries
ENSG00000175054 ATR hemangioblastoma missense_variant 40.0% (14/35) 1 entry
ENSG00000175054 ATR Breast Carcinoma by Gene Expression Profile stop_gained 3.182% (40/1257) 2 entries
ENSG00000175054 ATR pancreatic ductal adenocarcinoma missense_variant 3.446% (58/1683) 2 entries
ENSG00000175054 ATR Mantle cell lymphoma missense_variant 3.448% (2/58) 2 entries
ENSG00000175054 ATR female breast carcinoma frameshift_variant 2.482% (7/282) 2 entries
ENSG00000175054 ATR gastric intestinal type adenocarcinoma frameshift_variant 4.706% (4/85) 1 entry
ENSG00000175054 ATR esophageal adenocarcinoma sequence_alteration 6.216% (34/547) 1 entry
ENSG00000175054 ATR gastric adenocarcinoma stop_gained 3.928% (37/942) 1 entry
ENSG00000175054 ATR endometrium adenocarcinoma frameshift_variant 4.878% (2/41) 1 entry
ENSG00000175054 ATR Endometrial Endometrioid Adenocarcinoma missense_variant 3.105% (39/1256) 2 entries
ENSG00000175054 ATR squamous cell lung carcinoma sequence_alteration 3.94% (37/939) 1 entry
ENSG00000175054 ATR hairy cell leukemia missense_variant 9.524% (2/21) 1 entry
ENSG00000175054 ATR large cell lung carcinoma missense_variant 8.0% (2/25) 2 entries
ENSG00000175054 ATR gastric adenocarcinoma sequence_alteration 3.928% (37/942) 1 entry
ENSG00000175054 ATR ovarian serous adenocarcinoma stop_gained 3.863% (35/906) 1 entry
ENSG00000175054 ATR brain glioblastoma missense_variant 1.714% (21/1225) 3 entries
ENSG00000175054 ATR hepatocellular carcinoma sequence_alteration 2.742% (28/1021) 1 entry
ENSG00000175054 ATR Breast Carcinoma by Gene Expression Profile frameshift_variant 3.182% (40/1257) 2 entries
ENSG00000175054 ATR Gallbladder Adenocarcinoma sequence_alteration 4.124% (8/194) 1 entry
ENSG00000175054 ATR clear cell renal carcinoma sequence_alteration 0.7175% (11/1533) 1 entry
ENSG00000175054 ATR bladder transitional cell carcinoma missense_variant 6.1% (28/459) 3 entries
ENSG00000175054 ATR angiosarcoma sequence_alteration 6.383% (3/47) 1 entry
ENSG00000175054 ATR Endometrial Endometrioid Adenocarcinoma frameshift_variant 3.105% (39/1256) 2 entries
ENSG00000175054 ATR ovarian serous adenocarcinoma sequence_alteration 3.863% (35/906) 1 entry
ENSG00000175054 ATR ovarian serous adenocarcinoma missense_variant 3.863% (35/906) 3 entries
ENSG00000175054 ATR colon adenocarcinoma frameshift_variant 3.793% (49/1292) 4 entries
ENSG00000175054 ATR esophageal squamous cell carcinoma missense_variant 1.608% (11/684) 3 entries
ENSG00000175054 ATR melanoma sequence_alteration 7.018% (12/171) 2 entries
ENSG00000175054 ATR bladder transitional cell carcinoma sequence_alteration 6.1% (28/459) 2 entries
ENSG00000175054 ATR osteosarcoma sequence_alteration 1.316% (2/152) 2 entries
ENSG00000175054 ATR lobular breast carcinoma missense_variant 5.839% (16/274) 3 entries
ENSG00000175054 ATR Breast Carcinoma by Gene Expression Profile sequence_alteration 3.182% (40/1257) 1 entry
ENSG00000175054 ATR Malignant Ovarian Mixed Epithelial Tumor sequence_alteration 20.0% (2/10) 1 entry
ENSG00000175054 ATR colon adenocarcinoma missense_variant 3.793% (49/1292) 7 entries
ENSG00000175054 ATR non-small cell lung carcinoma missense_variant 4.167% (4/96) 3 entries
ENSG00000175054 ATR lung adenocarcinoma sequence_alteration 2.823% (78/2763) 3 entries
ENSG00000175054 ATR prostate carcinoma sequence_alteration 2.57% (11/428) 1 entry
ENSG00000175054 ATR pharyngeal squamous cell carcinoma missense_variant 4.938% (4/81) 1 entry
ENSG00000175054 ATR rectal adenocarcinoma frameshift_variant 2.364% (13/550) 2 entries
ENSG00000175054 ATR cecum adenocarcinoma stop_gained 4.833% (13/269) 2 entries
ENSG00000175054 ATR papillary thyroid carcinoma frameshift_variant 0.6135% (3/489) 1 entry
ENSG00000175054 ATR ovarian mucinous adenocarcinoma sequence_alteration 7.407% (2/27) 1 entry
ENSG00000175054 ATR prostate carcinoma missense_variant 2.57% (11/428) 2 entries
ENSG00000175054 ATR melanoma missense_variant 7.018% (12/171) 3 entries
ENSG00000175054 ATR thyroid carcinoma missense_variant 2.7% (25/926) 1 entry
ENSG00000175054 ATR Breast Carcinoma by Gene Expression Profile missense_variant 3.182% (40/1257) 2 entries
ENSG00000175054 ATR lung adenocarcinoma frameshift_variant 2.823% (78/2763) 2 entries
ENSG00000175054 ATR skin melanoma stop_gained 4.655% (54/1160) 1 entry
ENSG00000175054 ATR clear cell renal carcinoma missense_variant 0.7175% (11/1533) 1 entry
ENSG00000175054 ATR oral squamous cell carcinoma missense_variant 1.901% (5/263) 2 entries
ENSG00000175054 ATR bile duct adenocarcinoma stop_gained 2.08% (13/625) 1 entry
ENSG00000175054 ATR gastric adenocarcinoma frameshift_variant 3.928% (37/942) 2 entries
ENSG00000175054 ATR hepatocellular carcinoma frameshift_variant 2.742% (28/1021) 2 entries
ENSG00000175054 ATR Invasive Breast Carcinoma missense_variant 16.33% (8/49) 1 entry
ENSG00000175054 ATR hepatocellular carcinoma missense_variant 2.742% (28/1021) 2 entries
ENSG00000175054 ATR anaplastic oligodendroglioma missense_variant 2.326% (2/86) 2 entries
ENSG00000175054 ATR head and neck squamous cell carcinoma missense_variant 0.4525% (3/663) 1 entry
ENSG00000175054 ATR breast carcinoma frameshift_variant 1.579% (26/1647) 1 entry
ENSG00000175054 ATR endometrial carcinoma missense_variant 6.897% (2/29) 2 entries
ENSG00000175054 ATR HER2 Positive Breast Carcinoma stop_gained 9.42% (13/138) 1 entry
ENSG00000175054 ATR lung adenocarcinoma stop_gained 2.823% (78/2763) 4 entries
ENSG00000175054 ATR prostate adenocarcinoma frameshift_variant 3.517% (76/2161) 1 entry
ENSG00000175054 ATR squamous cell lung carcinoma missense_variant 3.94% (37/939) 4 entries
ENSG00000175054 ATR nasopharyngeal squamous cell carcinoma missense_variant 1.19% (3/252) 2 entries
ENSG00000175054 ATR gastric adenocarcinoma missense_variant 3.928% (37/942) 3 entries
ENSG00000175054 ATR salivary gland carcinoma stop_gained 3.03% (1/33) 1 entry
ENSG00000175054 ATR Prostate Small Cell Carcinoma missense_variant 5.263% (1/19) 1 entry
ENSG00000175054 ATR Intimal Sarcoma missense_variant 12.5% (1/8) 1 entry
ENSG00000175054 ATR Merkel cell skin cancer stop_gained 3.191% (3/94) 1 entry
ENSG00000175054 ATR breast phyllodes tumor missense_variant 1.786% (1/56) 1 entry
ENSG00000175054 ATR Thyroid Gland Undifferentiated (Anaplastic) Carcinoma missense_variant 0.3788% (1/264) 1 entry
ENSG00000175054 ATR Duodenal Adenocarcinoma missense_variant 5.882% (1/17) 1 entry
ENSG00000175054 ATR Tonsillar Squamous Cell Carcinoma missense_variant 11.11% (1/9) 1 entry
ENSG00000175054 ATR ependymoma sequence_alteration 1.852% (1/54) 1 entry
ENSG00000175054 ATR Merkel cell skin cancer sequence_alteration 3.191% (3/94) 1 entry
ENSG00000175054 ATR squamous cell lung carcinoma stop_gained 3.94% (37/939) 1 entry
ENSG00000175054 ATR angiosarcoma missense_variant 6.383% (3/47) 1 entry
ENSG00000175054 ATR Adamantinomatous Craniopharyngioma missense_variant 7.692% (1/13) 1 entry
ENSG00000175054 ATR esophageal adenocarcinoma stop_gained 6.216% (34/547) 1 entry
ENSG00000175054 ATR Pancreatic Acinar Cell Carcinoma frameshift_variant 2.941% (1/34) 1 entry
ENSG00000175054 ATR bile duct adenocarcinoma sequence_alteration 2.08% (13/625) 1 entry
ENSG00000175054 ATR diffuse large B-cell lymphoma missense_variant 0.5405% (2/370) 1 entry
ENSG00000175054 ATR pharyngeal squamous cell carcinoma frameshift_variant 4.938% (4/81) 1 entry
ENSG00000175054 ATR papillary thyroid carcinoma missense_variant 0.6135% (3/489) 1 entry
ENSG00000175054 ATR Endometrial Clear Cell Adenocarcinoma frameshift_variant 7.407% (2/27) 1 entry
ENSG00000175054 ATR Gallbladder Adenocarcinoma conservative_inframe_deletion 4.124% (8/194) 1 entry
ENSG00000175054 ATR anaplastic astrocytoma missense_variant 1.449% (2/138) 1 entry
ENSG00000175054 ATR melanoma stop_gained 7.018% (12/171) 1 entry
ENSG00000175054 ATR small intestinal adenocarcinoma stop_gained 4.762% (1/21) 1 entry
ENSG00000175054 ATR ovarian clear cell adenocarcinoma sequence_alteration 5.405% (2/37) 1 entry
ENSG00000175054 ATR Malignant Ovarian Mixed Epithelial Tumor stop_gained 20.0% (2/10) 1 entry
ENSG00000175054 ATR anaplastic astrocytoma stop_gained 1.449% (2/138) 1 entry
ENSG00000175054 ATR melanoma frameshift_variant 7.018% (12/171) 1 entry
ENSG00000175054 ATR laryngeal squamous cell carcinoma missense_variant 2.439% (1/41) 1 entry
ENSG00000175054 ATR Lung Sarcomatoid Carcinoma missense_variant 7.143% (1/14) 1 entry
ENSG00000175054 ATR leiomyosarcoma missense_variant 1.0% (1/100) 1 entry
ENSG00000175054 ATR multiple myeloma missense_variant 0.2079% (1/481) 1 entry
ENSG00000175054 ATR pseudomyxoma peritonei missense_variant 10.0% (1/10) 1 entry
ENSG00000175054 ATR marginal zone B-cell lymphoma missense_variant 3.333% (1/30) 1 entry
ENSG00000175054 ATR Pleural Mesothelioma missense_variant 0.7353% (1/136) 1 entry
ENSG00000175054 ATR basal cell carcinoma sequence_alteration 11.76% (8/68) 1 entry
ENSG00000175054 ATR urothelial carcinoma sequence_alteration 8.14% (7/86) 1 entry
ENSG00000175054 ATR Gastrointestinal stromal tumor frameshift_variant 0.6757% (1/148) 1 entry
ENSG00000175054 ATR gastric tubular adenocarcinoma missense_variant 50.0% (1/2) 1 entry
ENSG00000175054 ATR Endometrial Clear Cell Adenocarcinoma missense_variant 7.407% (2/27) 1 entry
ENSG00000175054 ATR Thymic Undifferentiated Carcinoma missense_variant 16.67% (1/6) 1 entry
ENSG00000175054 ATR small cell lung carcinoma sequence_alteration 4.289% (19/443) 1 entry
ENSG00000175054 ATR bronchoalveolar adenocarcinoma missense_variant 8.696% (2/23) 1 entry
ENSG00000175054 ATR bronchoalveolar adenocarcinoma sequence_alteration 8.696% (2/23) 1 entry
ENSG00000175054 ATR ulcerative colitis missense_variant 11.11% (1/9) 1 entry
ENSG00000175054 ATR small cell lung carcinoma frameshift_variant 4.289% (19/443) 1 entry
ENSG00000175054 ATR neoplasm of mature B-cells missense_variant 1.667% (1/60) 1 entry
ENSG00000175054 ATR esophageal adenocarcinoma frameshift_variant 6.216% (34/547) 1 entry
ENSG00000175054 ATR salivary gland squamous cell carcinoma missense_variant 50.0% (1/2) 1 entry
ENSG00000175054 ATR Pleural Epithelioid Mesothelioma missense_variant 0.5025% (1/199) 1 entry
ENSG00000175054 ATR gastric adenocarcinoma conservative_inframe_deletion 3.928% (37/942) 1 entry
ENSG00000175054 ATR pancreatic ductal adenocarcinoma stop_gained 3.446% (58/1683) 1 entry
ENSG00000175054 ATR nasal cavity and paranasal sinus carcinoma sequence_alteration 4.348% (1/23) 1 entry
ENSG00000175054 ATR neoplasm missense_variant 6.897% (2/29) 1 entry
ENSG00000175054 ATR acute myeloid leukemia missense_variant 1.76% (16/909) 1 entry
ENSG00000175054 ATR ovarian clear cell adenocarcinoma missense_variant 5.405% (2/37) 1 entry
ENSG00000175054 ATR undifferentiated pleomorphic sarcoma missense_variant 1.613% (1/62) 1 entry
ENSG00000175054 ATR Small Intestinal Diffuse Large B-Cell Lymphoma missense_variant 50.0% (1/2) 1 entry
ENSG00000175054 ATR pharyngeal squamous cell carcinoma stop_gained 4.938% (4/81) 1 entry
ENSG00000175054 ATR small cell lung carcinoma stop_gained 4.289% (19/443) 1 entry
ENSG00000175054 ATR pharyngeal squamous cell carcinoma sequence_alteration 4.938% (4/81) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000175054 ATR SARC 0.0068 high
ENSG00000175054 ATR CHOL 0.038 low
ENSG00000175054 ATR UVM 0.012 low
ENSG00000175054 ATR UCEC 0.023 high
ENSG00000175054 ATR THCA 0.0097 high
ENSG00000175054 ATR ACC 0.027 high
ENSG00000175054 ATR LUSC 0.04 low
ENSG00000175054 ATR READ 0.013 low
ENSG00000175054 ATR KIRP 0.0062 low
ENSG00000175054 ATR PRAD 0.0079 low
ENSG00000175054 ATR LAML 0.016 low
ENSG00000175054 ATR GBM 0.01 low
ENSG00000175054 ATR SKCM 0.003 low
ENSG00000175054 ATR LIHC 0.00017 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000175054 ATR LUSC Amp 21.518712 0.565751 0.831460 0.810379
ENSG00000175054 ATR CESC Amp 7.659095 0.321354 0.934158 0.681356
ENSG00000175054 ATR ESCA Amp 2.635535 0.370057 0.761479 0.559783
ENSG00000175054 ATR HNSC Amp 11.783512 0.302132 0.680242 0.628352
ENSG00000175054 ATR STAD Amp 0.638114 0.127851 0.469853 0.278912
ENSG00000175054 ATR PRAD Amp 3.296283 0.080765 0.486257 0.148374
ENSG00000175054 ATR UCEC Amp 2.042532 0.133723 0.621236 0.224490
ENSG00000175054 ATR OV Amp 10.082867 0.548406 0.814300 0.656304