Ensembl ID ENSG00000175054 Gene ID 545 Accession 882
Gene Symbol ATR Alias FRP1;MEC1;SCKL;FCTCS;SCKL1 Full Name ATR serine/threonine kinase
Position 3 : 142449235 - 142578733 Length 129499 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]

ENSG00000175054 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000175054 0.92 4.89e-21 COAD
ENSG00000175054 0.96 2.11e-31 LUSC
ENSG00000175054 1.05 3.36e-20 STAD
ENSG00000175054 0.61 5.19e-14 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000175054 breast cancer 21849621
ENSG00000175054 colon cancer 23566654
ENSG00000175054 tumor 25253693
ENSG00000175054 breast cancer 26680552
ENSG00000175054 cancer 27823879
ENSG00000175054 breast cancer 28721278
ENSG00000175054 tumor 29038346
ENSG00000175054 cancer 29685176
ENSG00000175054 tumor 29740495
ENSG00000175054 cancer 29899559
ENSG00000175054 tumor 31092378
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000175054 colorectal adenocarcinoma stop_gained 6.662% (95/1426) 3 entries
ENSG00000175054 hemangioblastoma sequence_alteration 40.0% (14/35) 1 entry
ENSG00000175054 breast ductal adenocarcinoma stop_gained 5.501% (96/1745) 2 entries
ENSG00000175054 Ovarian Endometrioid Adenocarcinoma sequence_alteration 33.33% (6/18) 1 entry
ENSG00000175054 breast ductal adenocarcinoma missense_variant 5.501% (96/1745) 4 entries
ENSG00000175054 breast ductal adenocarcinoma conservative_inframe_deletion 5.501% (96/1745) 1 entry
ENSG00000175054 breast ductal adenocarcinoma frameshift_variant 5.501% (96/1745) 1 entry
ENSG00000175054 colorectal adenocarcinoma sequence_alteration 6.662% (95/1426) 3 entries
ENSG00000175054 colorectal adenocarcinoma frameshift_variant 6.662% (95/1426) 4 entries
ENSG00000175054 Ovarian Endometrioid Adenocarcinoma missense_variant 33.33% (6/18) 1 entry
ENSG00000175054 colorectal adenocarcinoma missense_variant 6.662% (95/1426) 7 entries
ENSG00000175054 breast carcinoma missense_variant 1.579% (26/1647) 2 entries
ENSG00000175054 lung adenocarcinoma missense_variant 2.823% (78/2763) 6 entries
ENSG00000175054 Merkel cell skin cancer missense_variant 3.191% (3/94) 2 entries
ENSG00000175054 urothelial carcinoma missense_variant 8.14% (7/86) 1 entry
ENSG00000175054 small cell lung carcinoma missense_variant 4.289% (19/443) 4 entries
ENSG00000175054 Mixed Lobular and Ductal Breast Carcinoma missense_variant 2.778% (2/72) 1 entry
ENSG00000175054 skin melanoma missense_variant 4.655% (54/1160) 9 entries
ENSG00000175054 esophageal squamous cell carcinoma frameshift_variant 1.608% (11/684) 2 entries
ENSG00000175054 prostate adenocarcinoma missense_variant 3.517% (76/2161) 2 entries
ENSG00000175054 oral squamous cell carcinoma stop_gained 1.901% (5/263) 2 entries
ENSG00000175054 basal cell carcinoma missense_variant 11.76% (8/68) 1 entry
ENSG00000175054 cervical squamous cell carcinoma missense_variant 2.462% (8/325) 1 entry
ENSG00000175054 esophageal adenocarcinoma missense_variant 6.216% (34/547) 2 entries
ENSG00000175054 rectal adenocarcinoma missense_variant 2.364% (13/550) 3 entries
ENSG00000175054 colon adenocarcinoma stop_gained 3.793% (49/1292) 4 entries
ENSG00000175054 breast carcinoma stop_gained 1.579% (26/1647) 3 entries
ENSG00000175054 papillary renal cell carcinoma missense_variant 1.538% (6/390) 2 entries
ENSG00000175054 chronic myelomonocytic leukemia missense_variant 3.158% (3/95) 1 entry
ENSG00000175054 bladder transitional cell carcinoma stop_gained 6.1% (28/459) 1 entry
ENSG00000175054 Uterine Carcinosarcoma missense_variant 6.667% (11/165) 1 entry
ENSG00000175054 colon adenocarcinoma sequence_alteration 3.793% (49/1292) 3 entries
ENSG00000175054 bile duct adenocarcinoma missense_variant 2.08% (13/625) 2 entries
ENSG00000175054 Gallbladder Adenocarcinoma missense_variant 4.124% (8/194) 2 entries
ENSG00000175054 cecum adenocarcinoma missense_variant 4.833% (13/269) 3 entries
ENSG00000175054 female breast carcinoma missense_variant 2.482% (7/282) 2 entries
ENSG00000175054 hemangioblastoma missense_variant 40.0% (14/35) 1 entry
ENSG00000175054 Breast Carcinoma by Gene Expression Profile stop_gained 3.182% (40/1257) 2 entries
ENSG00000175054 pancreatic ductal adenocarcinoma missense_variant 3.446% (58/1683) 2 entries
ENSG00000175054 Mantle cell lymphoma missense_variant 3.448% (2/58) 2 entries
ENSG00000175054 female breast carcinoma frameshift_variant 2.482% (7/282) 2 entries
ENSG00000175054 gastric intestinal type adenocarcinoma frameshift_variant 4.706% (4/85) 1 entry
ENSG00000175054 esophageal adenocarcinoma sequence_alteration 6.216% (34/547) 1 entry
ENSG00000175054 gastric adenocarcinoma stop_gained 3.928% (37/942) 1 entry
ENSG00000175054 endometrium adenocarcinoma frameshift_variant 4.878% (2/41) 1 entry
ENSG00000175054 Endometrial Endometrioid Adenocarcinoma missense_variant 3.105% (39/1256) 2 entries
ENSG00000175054 squamous cell lung carcinoma sequence_alteration 3.94% (37/939) 1 entry
ENSG00000175054 hairy cell leukemia missense_variant 9.524% (2/21) 1 entry
ENSG00000175054 large cell lung carcinoma missense_variant 8.0% (2/25) 2 entries
ENSG00000175054 gastric adenocarcinoma sequence_alteration 3.928% (37/942) 1 entry
ENSG00000175054 ovarian serous adenocarcinoma stop_gained 3.863% (35/906) 1 entry
ENSG00000175054 brain glioblastoma missense_variant 1.714% (21/1225) 3 entries
ENSG00000175054 hepatocellular carcinoma sequence_alteration 2.742% (28/1021) 1 entry
ENSG00000175054 Breast Carcinoma by Gene Expression Profile frameshift_variant 3.182% (40/1257) 2 entries
ENSG00000175054 Gallbladder Adenocarcinoma sequence_alteration 4.124% (8/194) 1 entry
ENSG00000175054 clear cell renal carcinoma sequence_alteration 0.7175% (11/1533) 1 entry
ENSG00000175054 bladder transitional cell carcinoma missense_variant 6.1% (28/459) 3 entries
ENSG00000175054 angiosarcoma sequence_alteration 6.383% (3/47) 1 entry
ENSG00000175054 Endometrial Endometrioid Adenocarcinoma frameshift_variant 3.105% (39/1256) 2 entries
ENSG00000175054 ovarian serous adenocarcinoma sequence_alteration 3.863% (35/906) 1 entry
ENSG00000175054 ovarian serous adenocarcinoma missense_variant 3.863% (35/906) 3 entries
ENSG00000175054 colon adenocarcinoma frameshift_variant 3.793% (49/1292) 4 entries
ENSG00000175054 esophageal squamous cell carcinoma missense_variant 1.608% (11/684) 3 entries
ENSG00000175054 melanoma sequence_alteration 7.018% (12/171) 2 entries
ENSG00000175054 bladder transitional cell carcinoma sequence_alteration 6.1% (28/459) 2 entries
ENSG00000175054 osteosarcoma sequence_alteration 1.316% (2/152) 2 entries
ENSG00000175054 lobular breast carcinoma missense_variant 5.839% (16/274) 3 entries
ENSG00000175054 Breast Carcinoma by Gene Expression Profile sequence_alteration 3.182% (40/1257) 1 entry
ENSG00000175054 Malignant Ovarian Mixed Epithelial Tumor sequence_alteration 20.0% (2/10) 1 entry
ENSG00000175054 colon adenocarcinoma missense_variant 3.793% (49/1292) 7 entries
ENSG00000175054 non-small cell lung carcinoma missense_variant 4.167% (4/96) 3 entries
ENSG00000175054 lung adenocarcinoma sequence_alteration 2.823% (78/2763) 3 entries
ENSG00000175054 prostate carcinoma sequence_alteration 2.57% (11/428) 1 entry
ENSG00000175054 pharyngeal squamous cell carcinoma missense_variant 4.938% (4/81) 1 entry
ENSG00000175054 rectal adenocarcinoma frameshift_variant 2.364% (13/550) 2 entries
ENSG00000175054 cecum adenocarcinoma stop_gained 4.833% (13/269) 2 entries
ENSG00000175054 papillary thyroid carcinoma frameshift_variant 0.6135% (3/489) 1 entry
ENSG00000175054 ovarian mucinous adenocarcinoma sequence_alteration 7.407% (2/27) 1 entry
ENSG00000175054 prostate carcinoma missense_variant 2.57% (11/428) 2 entries
ENSG00000175054 melanoma missense_variant 7.018% (12/171) 3 entries
ENSG00000175054 thyroid carcinoma missense_variant 2.7% (25/926) 1 entry
ENSG00000175054 Breast Carcinoma by Gene Expression Profile missense_variant 3.182% (40/1257) 2 entries
ENSG00000175054 lung adenocarcinoma frameshift_variant 2.823% (78/2763) 2 entries
ENSG00000175054 skin melanoma stop_gained 4.655% (54/1160) 1 entry
ENSG00000175054 clear cell renal carcinoma missense_variant 0.7175% (11/1533) 1 entry
ENSG00000175054 oral squamous cell carcinoma missense_variant 1.901% (5/263) 2 entries
ENSG00000175054 bile duct adenocarcinoma stop_gained 2.08% (13/625) 1 entry
ENSG00000175054 gastric adenocarcinoma frameshift_variant 3.928% (37/942) 2 entries
ENSG00000175054 hepatocellular carcinoma frameshift_variant 2.742% (28/1021) 2 entries
ENSG00000175054 Invasive Breast Carcinoma missense_variant 16.33% (8/49) 1 entry
ENSG00000175054 hepatocellular carcinoma missense_variant 2.742% (28/1021) 2 entries
ENSG00000175054 anaplastic oligodendroglioma missense_variant 2.326% (2/86) 2 entries
ENSG00000175054 head and neck squamous cell carcinoma missense_variant 0.4525% (3/663) 1 entry
ENSG00000175054 breast carcinoma frameshift_variant 1.579% (26/1647) 1 entry
ENSG00000175054 endometrial carcinoma missense_variant 6.897% (2/29) 2 entries
ENSG00000175054 HER2 Positive Breast Carcinoma stop_gained 9.42% (13/138) 1 entry
ENSG00000175054 lung adenocarcinoma stop_gained 2.823% (78/2763) 4 entries
ENSG00000175054 prostate adenocarcinoma frameshift_variant 3.517% (76/2161) 1 entry
ENSG00000175054 squamous cell lung carcinoma missense_variant 3.94% (37/939) 4 entries
ENSG00000175054 nasopharyngeal squamous cell carcinoma missense_variant 1.19% (3/252) 2 entries
ENSG00000175054 gastric adenocarcinoma missense_variant 3.928% (37/942) 3 entries
ENSG00000175054 salivary gland carcinoma stop_gained 3.03% (1/33) 1 entry
ENSG00000175054 Prostate Small Cell Carcinoma missense_variant 5.263% (1/19) 1 entry
ENSG00000175054 Intimal Sarcoma missense_variant 12.5% (1/8) 1 entry
ENSG00000175054 Merkel cell skin cancer stop_gained 3.191% (3/94) 1 entry
ENSG00000175054 breast phyllodes tumor missense_variant 1.786% (1/56) 1 entry
ENSG00000175054 Thyroid Gland Undifferentiated (Anaplastic) Carcinoma missense_variant 0.3788% (1/264) 1 entry
ENSG00000175054 Duodenal Adenocarcinoma missense_variant 5.882% (1/17) 1 entry
ENSG00000175054 Tonsillar Squamous Cell Carcinoma missense_variant 11.11% (1/9) 1 entry
ENSG00000175054 ependymoma sequence_alteration 1.852% (1/54) 1 entry
ENSG00000175054 Merkel cell skin cancer sequence_alteration 3.191% (3/94) 1 entry
ENSG00000175054 squamous cell lung carcinoma stop_gained 3.94% (37/939) 1 entry
ENSG00000175054 angiosarcoma missense_variant 6.383% (3/47) 1 entry
ENSG00000175054 Adamantinomatous Craniopharyngioma missense_variant 7.692% (1/13) 1 entry
ENSG00000175054 esophageal adenocarcinoma stop_gained 6.216% (34/547) 1 entry
ENSG00000175054 Pancreatic Acinar Cell Carcinoma frameshift_variant 2.941% (1/34) 1 entry
ENSG00000175054 bile duct adenocarcinoma sequence_alteration 2.08% (13/625) 1 entry
ENSG00000175054 diffuse large B-cell lymphoma missense_variant 0.5405% (2/370) 1 entry
ENSG00000175054 pharyngeal squamous cell carcinoma frameshift_variant 4.938% (4/81) 1 entry
ENSG00000175054 papillary thyroid carcinoma missense_variant 0.6135% (3/489) 1 entry
ENSG00000175054 Endometrial Clear Cell Adenocarcinoma frameshift_variant 7.407% (2/27) 1 entry
ENSG00000175054 Gallbladder Adenocarcinoma conservative_inframe_deletion 4.124% (8/194) 1 entry
ENSG00000175054 anaplastic astrocytoma missense_variant 1.449% (2/138) 1 entry
ENSG00000175054 melanoma stop_gained 7.018% (12/171) 1 entry
ENSG00000175054 small intestinal adenocarcinoma stop_gained 4.762% (1/21) 1 entry
ENSG00000175054 ovarian clear cell adenocarcinoma sequence_alteration 5.405% (2/37) 1 entry
ENSG00000175054 Malignant Ovarian Mixed Epithelial Tumor stop_gained 20.0% (2/10) 1 entry
ENSG00000175054 anaplastic astrocytoma stop_gained 1.449% (2/138) 1 entry
ENSG00000175054 melanoma frameshift_variant 7.018% (12/171) 1 entry
ENSG00000175054 laryngeal squamous cell carcinoma missense_variant 2.439% (1/41) 1 entry
ENSG00000175054 Lung Sarcomatoid Carcinoma missense_variant 7.143% (1/14) 1 entry
ENSG00000175054 leiomyosarcoma missense_variant 1.0% (1/100) 1 entry
ENSG00000175054 multiple myeloma missense_variant 0.2079% (1/481) 1 entry
ENSG00000175054 pseudomyxoma peritonei missense_variant 10.0% (1/10) 1 entry
ENSG00000175054 marginal zone B-cell lymphoma missense_variant 3.333% (1/30) 1 entry
ENSG00000175054 Pleural Mesothelioma missense_variant 0.7353% (1/136) 1 entry
ENSG00000175054 basal cell carcinoma sequence_alteration 11.76% (8/68) 1 entry
ENSG00000175054 urothelial carcinoma sequence_alteration 8.14% (7/86) 1 entry
ENSG00000175054 Gastrointestinal stromal tumor frameshift_variant 0.6757% (1/148) 1 entry
ENSG00000175054 gastric tubular adenocarcinoma missense_variant 50.0% (1/2) 1 entry
ENSG00000175054 Endometrial Clear Cell Adenocarcinoma missense_variant 7.407% (2/27) 1 entry
ENSG00000175054 Thymic Undifferentiated Carcinoma missense_variant 16.67% (1/6) 1 entry
ENSG00000175054 small cell lung carcinoma sequence_alteration 4.289% (19/443) 1 entry
ENSG00000175054 bronchoalveolar adenocarcinoma missense_variant 8.696% (2/23) 1 entry
ENSG00000175054 bronchoalveolar adenocarcinoma sequence_alteration 8.696% (2/23) 1 entry
ENSG00000175054 ulcerative colitis missense_variant 11.11% (1/9) 1 entry
ENSG00000175054 small cell lung carcinoma frameshift_variant 4.289% (19/443) 1 entry
ENSG00000175054 neoplasm of mature B-cells missense_variant 1.667% (1/60) 1 entry
ENSG00000175054 esophageal adenocarcinoma frameshift_variant 6.216% (34/547) 1 entry
ENSG00000175054 salivary gland squamous cell carcinoma missense_variant 50.0% (1/2) 1 entry
ENSG00000175054 Pleural Epithelioid Mesothelioma missense_variant 0.5025% (1/199) 1 entry
ENSG00000175054 gastric adenocarcinoma conservative_inframe_deletion 3.928% (37/942) 1 entry
ENSG00000175054 pancreatic ductal adenocarcinoma stop_gained 3.446% (58/1683) 1 entry
ENSG00000175054 nasal cavity and paranasal sinus carcinoma sequence_alteration 4.348% (1/23) 1 entry
ENSG00000175054 neoplasm missense_variant 6.897% (2/29) 1 entry
ENSG00000175054 acute myeloid leukemia missense_variant 1.76% (16/909) 1 entry
ENSG00000175054 ovarian clear cell adenocarcinoma missense_variant 5.405% (2/37) 1 entry
ENSG00000175054 undifferentiated pleomorphic sarcoma missense_variant 1.613% (1/62) 1 entry
ENSG00000175054 Small Intestinal Diffuse Large B-Cell Lymphoma missense_variant 50.0% (1/2) 1 entry
ENSG00000175054 pharyngeal squamous cell carcinoma stop_gained 4.938% (4/81) 1 entry
ENSG00000175054 small cell lung carcinoma stop_gained 4.289% (19/443) 1 entry
ENSG00000175054 pharyngeal squamous cell carcinoma sequence_alteration 4.938% (4/81) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000175054 SARC 0.0068 high
ENSG00000175054 CHOL 0.038 low
ENSG00000175054 UVM 0.012 low
ENSG00000175054 UCEC 0.023 high
ENSG00000175054 THCA 0.0097 high
ENSG00000175054 ACC 0.027 high
ENSG00000175054 LUSC 0.04 low
ENSG00000175054 READ 0.013 low
ENSG00000175054 KIRP 0.0062 low
ENSG00000175054 PRAD 0.0079 low
ENSG00000175054 LAML 0.016 low
ENSG00000175054 GBM 0.01 low
ENSG00000175054 SKCM 0.003 low
ENSG00000175054 LIHC 0.00017 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000175054 LUSC Amp 21.518712 0.565751 0.831460 0.810379
ENSG00000175054 CESC Amp 7.659095 0.321354 0.934158 0.681356
ENSG00000175054 ESCA Amp 2.635535 0.370057 0.761479 0.559783
ENSG00000175054 HNSC Amp 11.783512 0.302132 0.680242 0.628352
ENSG00000175054 STAD Amp 0.638114 0.127851 0.469853 0.278912
ENSG00000175054 PRAD Amp 3.296283 0.080765 0.486257 0.148374
ENSG00000175054 UCEC Amp 2.042532 0.133723 0.621236 0.224490
ENSG00000175054 OV Amp 10.082867 0.548406 0.814300 0.656304