Ensembl ID ENSG00000174405 Gene ID 3981 Accession 6601
Gene Symbol LIG4 Alias LIG4S Full Name DNA ligase 4
Position 13 : 108207439 - 108218368 Length 10930 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

ENSG00000174405 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000174405 -0.8 5.02e-49 KIRC
ENSG00000174405 -0.8 1.90e-21 LUSC
ENSG00000174405 -1.4 2.13e-13 GBM
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000174405 tumor 11779495
ENSG00000174405 breast cancer 12023982
ENSG00000174405 tumour 12471202
ENSG00000174405 cancer 12698192
ENSG00000174405 lung cancer 15609317
ENSG00000174405 breast cancer 16177181
ENSG00000174405 breast cancer 16485136
ENSG00000174405 prostate cancer 16638864
ENSG00000174405 tumor 17700532
ENSG00000174405 cancer 18165945
ENSG00000174405 cancer 18508926
ENSG00000174405 cancer 18568480
ENSG00000174405 ovarian cancer 19127255
ENSG00000174405 pancreatic cancer 19147782
ENSG00000174405 tumor 19174520
ENSG00000174405 ovarian cancer 20386703
ENSG00000174405 cancer 20445776
ENSG00000174405 thyroid cancer 20811692
ENSG00000174405 nonsmall cell lung cancer 21717429
ENSG00000174405 head and neck cancer 21877955
ENSG00000174405 breast cancer 22112941
ENSG00000174405 breast cancer 22994770
ENSG00000174405 Ovarian cancer 23538968
ENSG00000174405 cervical cancer 23642098
ENSG00000174405 cancer 23663450
ENSG00000174405 prostate cancer 23936089
ENSG00000174405 colorectal cancer 24282031
ENSG00000174405 non-small cell lung cancer 24722796
ENSG00000174405 cancer 24845497
ENSG00000174405 cancer 25314918
ENSG00000174405 cancer 25321468
ENSG00000174405 prostate cancer 25540025
ENSG00000174405 nasopharyngeal cancer 25605214
ENSG00000174405 Lung Cancer 25811031
ENSG00000174405 cancer 25973104
ENSG00000174405 colorectal cancer 26108778
ENSG00000174405 prostate cancers 26134445
ENSG00000174405 cancer 27009971
ENSG00000174405 cancer 27163284
ENSG00000174405 tumor 27235626
ENSG00000174405 tumor 27705909
ENSG00000174405 pancreatic cancer 27877219
ENSG00000174405 rectal cancer 28000198
ENSG00000174405 DLBCL 28211887
ENSG00000174405 breast cancer 28475402
ENSG00000174405 cancer 28684677
ENSG00000174405 breast cancer 28780472
ENSG00000174405 childhood cancer 28976792
ENSG00000174405 breast cancer 29145865
ENSG00000174405 colon cancer 29277765
ENSG00000174405 cancer 29468011
ENSG00000174405 cancers 30038324
ENSG00000174405 cancers 30271587
ENSG00000174405 cancer 30627327
ENSG00000174405 breast cancer 30838131
ENSG00000174405 colorectal cancer 31243170
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000174405 MESO 0.032 low
ENSG00000174405 PAAD 0.0031 low
ENSG00000174405 UCEC 0.03 high
ENSG00000174405 THCA 0.012 high
ENSG00000174405 ACC 0.047 high
ENSG00000174405 LGG 0.02 high
ENSG00000174405 LUSC 0.0017 high
ENSG00000174405 KIRP 0.0012 low
ENSG00000174405 THYM 0.012 low
ENSG00000174405 ESCA 0.0065 high
ENSG00000174405 PRAD 0.00037 low
ENSG00000174405 BLCA 0.02 low
ENSG00000174405 SKCM 0.00015 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000174405 LUAD Amp 1.558953 0.139483 0.524214 0.147287
ENSG00000174405 LGG Amp 1.530134 0.056302 0.724017 0.040936
ENSG00000174405 CESC Amp 2.554346 0.197007 0.534876 0.227119
ENSG00000174405 READ Amp 2.082019 0.192085 1.019339 0.709091
ENSG00000174405 COAD Amp 4.811386 0.137863 0.921454 0.578714
ENSG00000174405 SARC Amp 0.890912 0.270617 0.785477 0.171206
ENSG00000174405 LIHC Amp 6.123670 0.227112 0.743142 0.175676
ENSG00000174405 DLBC Del 0.605214 0.117287 0.549635 0.145833
ENSG00000174405 BLCA Amp 1.164085 0.181631 0.502260 0.333333
ENSG00000174405 BRCA Amp 0.713805 0.145404 0.583325 0.156481