Ensembl ID ENSG00000174371 Gene ID 9156 Accession 3511
Gene Symbol EXO1 Alias HEX1;hExoI Full Name exonuclease 1
Position 1 : 241847967 - 241889939 Length 41973 bases Strand Plus strand
Status Confidence Main interacting RNAsdiverseRBP type Non-canonical_RBPs
Summary This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]

ENSG00000174371 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000174371 EXO1 1.68 5.63e-37 KIRC
ENSG00000174371 EXO1 1.71 8.13e-48 HNSC
ENSG00000174371 EXO1 2.15 3.79e-18 BLCA
ENSG00000174371 EXO1 3.43 1.54e-176 BRCA
ENSG00000174371 EXO1 1.55 2.82e-45 COAD
ENSG00000174371 EXO1 4.31 6.35e-292 LUSC
ENSG00000174371 EXO1 1.29 2.17e-12 PRAD
ENSG00000174371 EXO1 3.64 3.63e-18 GBM
ENSG00000174371 EXO1 1.88 5.25e-14 KIRP
ENSG00000174371 EXO1 3.60 1.94e-77 LIHC
ENSG00000174371 EXO1 2.15 5.26e-35 STAD
ENSG00000174371 EXO1 3.50 1.70e-87 UCEC
ENSG00000174371 EXO1 2.22 1.40e-16 ESCA
ENSG00000174371 EXO1 4.07 2.36e-25 CHOL
ENSG00000174371 EXO1 5.78 7.36e-53 CESC
ENSG00000174371 EXO1 3.59 3.04e-98 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000174371 EXO1 liver cancer 10856833
ENSG00000174371 EXO1 hereditary nonpolyposis colorectal cancer (HNPCC) 11375940
ENSG00000174371 EXO1 hereditary nonpolyposis colorectal cancer 12414623
ENSG00000174371 EXO1 hereditary nonpolyposis colorectal cancer 12517792
ENSG00000174371 EXO1 cancer 12629043
ENSG00000174371 EXO1 colorectal tumors 14623461
ENSG00000174371 EXO1 colorectal cancer 15550454
ENSG00000174371 EXO1 hereditary nonpolyposis colorectal cancer (HNPCC) 17426132
ENSG00000174371 EXO1 lung cancer 18079015
ENSG00000174371 EXO1 tumor 19237629
ENSG00000174371 EXO1 breast cancer 19522845
ENSG00000174371 EXO1 breast cancer 19846925
ENSG00000174371 EXO1 tumors 20218738
ENSG00000174371 EXO1 tumor 20593048
ENSG00000174371 EXO1 colorectal cancer 20854105
ENSG00000174371 EXO1 cancer 22014273
ENSG00000174371 EXO1 cervical cancer 22146767
ENSG00000174371 EXO1 colorectal cancer 22735708
ENSG00000174371 EXO1 tumor 23555580
ENSG00000174371 EXO1 cancer 23578789
ENSG00000174371 EXO1 breast cancer 23796531
ENSG00000174371 EXO1 tumors 23960188
ENSG00000174371 EXO1 breast cancer 24147022
ENSG00000174371 EXO1 colon tumors 24484585
ENSG00000174371 EXO1 cancer 24761866
ENSG00000174371 EXO1 ovarian cancer 24824601
ENSG00000174371 EXO1 cancer 24829445
ENSG00000174371 EXO1 colorectal cancer 25294706
ENSG00000174371 EXO1 breast cancer 25537147
ENSG00000174371 EXO1 HNSCC 25598504
ENSG00000174371 EXO1 cancer 26160886
ENSG00000174371 EXO1 cancers 26215063
ENSG00000174371 EXO1 lung cancer 26379914
ENSG00000174371 EXO1 cancer 26519824
ENSG00000174371 EXO1 prostate cancer 26646562
ENSG00000174371 EXO1 colorectal cancer 26649135
ENSG00000174371 EXO1 breast tumors 26679694
ENSG00000174371 EXO1 cancer 26811195
ENSG00000174371 EXO1 cancer 26966378
ENSG00000174371 EXO1 tumor 27088619
ENSG00000174371 EXO1 Cancer 27387683
ENSG00000174371 EXO1 tumor 27467592
ENSG00000174371 EXO1 cancers 27494243
ENSG00000174371 EXO1 ovarian cancer 27806724
ENSG00000174371 EXO1 prostate cancer 28206966
ENSG00000174371 EXO1 cancer 28279982
ENSG00000174371 EXO1 HNSCC 28686330
ENSG00000174371 EXO1 cancer 28918054
ENSG00000174371 EXO1 ovarian cancer 29042795
ENSG00000174371 EXO1 cancer 29069084
ENSG00000174371 EXO1 ovarian cancer 29670073
ENSG00000174371 EXO1 cancer 29717121
ENSG00000174371 EXO1 pancreatic cancer 29940740
ENSG00000174371 EXO1 HNSCC 30038702
ENSG00000174371 EXO1 tumor 30328366
ENSG00000174371 EXO1 Cancer 30585186
ENSG00000174371 EXO1 bladder cancer 30588253
ENSG00000174371 EXO1 prostate cancer 30775798
ENSG00000174371 EXO1 cancer 30947698
ENSG00000174371 EXO1 HNSCC 31035658
ENSG00000174371 EXO1 cancer 31087508
ENSG00000174371 EXO1 cancer 31179925
ENSG00000174371 EXO1 tumors 31292272
ENSG00000174371 EXO1 breast cancer 31611891
ENSG00000174371 EXO1 lung cancer 31611952
ENSG00000174371 EXO1 breast cancer 31777591
ENSG00000174371 EXO1 tumour 9396823
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000174371 EXO1 SARC 0.0033 high
ENSG00000174371 EXO1 CHOL 0.022 high
ENSG00000174371 EXO1 PAAD 0.00045 high
ENSG00000174371 EXO1 UCEC 8e-04 high
ENSG00000174371 EXO1 THCA 0.012 low
ENSG00000174371 EXO1 LUSC 0.027 low
ENSG00000174371 EXO1 HNSC 0.018 high
ENSG00000174371 EXO1 READ 0.024 low
ENSG00000174371 EXO1 LUAD 0.00013 high
ENSG00000174371 EXO1 PCPG 0.0051 high
ENSG00000174371 EXO1 THYM 0.001 low
ENSG00000174371 EXO1 BRCA 0.0086 high
ENSG00000174371 EXO1 OV 0.048 low
ENSG00000174371 EXO1 DLBC 0.046 low
ENSG00000174371 EXO1 BLCA 0.033 high
ENSG00000174371 EXO1 LAML 0.018 high
ENSG00000174371 EXO1 SKCM 4e-04 high
ENSG00000174371 EXO1 CESC 0.016 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000174371 EXO1 LUAD Amp 1.118714 0.128519 0.495368 0.682171
ENSG00000174371 EXO1 CESC Amp 0.710411 0.128626 0.582079 0.508475
ENSG00000174371 EXO1 SARC Del 5.776532 0.230010 0.506459 0.319066
ENSG00000174371 EXO1 SKCM Amp 4.367037 0.226494 0.693073 0.542234
ENSG00000174371 EXO1 LIHC Amp 6.066776 0.226012 0.846366 0.716216
ENSG00000174371 EXO1 DLBC Del 2.626100 0.234574 0.584837 0.166667
ENSG00000174371 EXO1 BRCA Amp 15.262717 0.311570 0.796888 0.731481
ENSG00000174371 EXO1 UCEC Amp 1.324987 0.118649 0.840799 0.408163
ENSG00000174371 EXO1 KIRC Del 0.615067 0.023580 0.458296 0.079545
ENSG00000174371 EXO1 OV Amp 7.596016 0.503136 0.736819 0.538860