Ensembl ID ENSG00000174231 Gene ID 10594 Accession 17340
Gene Symbol PRPF8 Alias PRP8;RP13;HPRP8;PRPC8;SNRNP220 Full Name pre-mRNA processing factor 8
Position 17 : 1650629 - 1684867 Length 34239 bases Strand Minus strand
Status Confidence Main interacting RNAssnRNARBP type Canonical_RBPs
Summary Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008]

ENSG00000174231 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000174231 PRPF8 cancers 24556687
ENSG00000174231 PRPF8 AML 24781015
ENSG00000174231 PRPF8 cancer 25257309
ENSG00000174231 PRPF8 Prostate Cancer 26371515
ENSG00000174231 PRPF8 cancer 29023197
ENSG00000174231 PRPF8 cancer 30545302
ENSG00000174231 PRPF8 acute myeloid leukemia (AML) 31766606
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000174231 PRPF8 MESO 0.024 low
ENSG00000174231 PRPF8 CHOL 0.014 high
ENSG00000174231 PRPF8 UVM 0.032 low
ENSG00000174231 PRPF8 PAAD 0.0073 low
ENSG00000174231 PRPF8 UCEC 0.033 low
ENSG00000174231 PRPF8 LGG 0.041 low
ENSG00000174231 PRPF8 LUSC 0.041 low
ENSG00000174231 PRPF8 READ 0.037 low
ENSG00000174231 PRPF8 PCPG 0.0041 low
ENSG00000174231 PRPF8 THYM 0.0097 low
ENSG00000174231 PRPF8 ESCA 0.0077 low
ENSG00000174231 PRPF8 BLCA 0.0046 high
ENSG00000174231 PRPF8 GBM 0.034 high
ENSG00000174231 PRPF8 SKCM 0.031 high
ENSG00000174231 PRPF8 LIHC 0.01 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000174231 PRPF8 LUAD Del 2.779977 0.074904 0.368034 0.546512
ENSG00000174231 PRPF8 SARC Del 4.518792 0.208526 0.541350 0.346304
ENSG00000174231 PRPF8 LIHC Del 6.208512 0.133722 0.644349 0.564865
ENSG00000174231 PRPF8 UCEC Del 1.007245 0.052023 0.581281 0.224490