Ensembl ID ENSG00000173141 Gene ID 78988 Accession 14514
Gene Symbol MRPL57 Alias mL63;MRP63;bMRP63 Full Name mitochondrial ribosomal protein L57
Position 13 : 21176658 - 21179084 Length 2427 bases Strand Plus strand
Status Confidence Main interacting RNAsrRNARBP type Canonical_RBPs
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein which belongs to an undetermined ribosomal subunit and which seems to be specific to animal mitoribosomes. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 3p, 5q, 8q, 14q, and Y. [provided by RefSeq, Jul 2008]

ENSG00000173141 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000173141 MRPL57 0.49 2.10e-15 BRCA
ENSG00000173141 MRPL57 0.85 3.01e-15 COAD
ENSG00000173141 MRPL57 0.67 2.47e-12 UCEC
ENSG00000173141 MRPL57 -1.2 3.14e-11 CHOL
Ensembl ID Gene symbol Cancer types Pubmed ID
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000173141 MRPL57 MESO 0.0019 low
ENSG00000173141 MRPL57 UVM 0.00038 high
ENSG00000173141 MRPL57 PAAD 0.00059 low
ENSG00000173141 MRPL57 UCEC 0.0043 low
ENSG00000173141 MRPL57 LGG 0.01 low
ENSG00000173141 MRPL57 READ 0.015 low
ENSG00000173141 MRPL57 KIRP 0.0094 low
ENSG00000173141 MRPL57 KICH 0.048 high
ENSG00000173141 MRPL57 LUAD 0.05 high
ENSG00000173141 MRPL57 THYM 0.039 low
ENSG00000173141 MRPL57 BRCA 0.0093 low
ENSG00000173141 MRPL57 ESCA 0.0052 high
ENSG00000173141 MRPL57 OV 0.023 low
ENSG00000173141 MRPL57 DLBC 0.021 low
ENSG00000173141 MRPL57 KIRC 0.033 low
ENSG00000173141 MRPL57 PRAD 0.044 low
ENSG00000173141 MRPL57 SKCM 0.01 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000173141 MRPL57 LUSC Del 7.801551 0.135061 0.387800 0.674651
ENSG00000173141 MRPL57 LUAD Del 11.026972 0.133233 0.346874 0.569767
ENSG00000173141 MRPL57 LGG Del 2.932164 0.060147 0.450994 0.241715
ENSG00000173141 MRPL57 CESC Del 7.518827 0.153773 0.484652 0.342373
ENSG00000173141 MRPL57 READ Amp 5.333537 0.311176 1.065452 0.703030
ENSG00000173141 MRPL57 COAD Amp 10.861324 0.219468 0.927304 0.596452
ENSG00000173141 MRPL57 UCS Del 1.343147 0.257129 0.514583 0.535714
ENSG00000173141 MRPL57 SARC Del 2.035928 0.157974 0.567099 0.478599
ENSG00000173141 MRPL57 GBM Del 1.736199 0.064546 0.551805 0.327556
ENSG00000173141 MRPL57 ESCA Del 1.015461 0.105911 0.384200 0.413043
ENSG00000173141 MRPL57 SKCM Del 0.611210 0.064605 0.465220 0.239782
ENSG00000173141 MRPL57 HNSC Del 21.540787 0.179405 0.411990 0.446360
ENSG00000173141 MRPL57 LIHC Del 3.805502 0.108265 0.550483 0.348649
ENSG00000173141 MRPL57 BRCA Del 3.161974 0.082402 0.461477 0.406481
ENSG00000173141 MRPL57 UCEC Del 1.859425 0.061866 0.519307 0.178108
ENSG00000173141 MRPL57 MESO Del 1.425121 0.154309 0.477178 0.448276
ENSG00000173141 MRPL57 OV Del 3.243318 0.223075 0.610252 0.590674