Ensembl ID ENSG00000172757 Gene ID 1072 Accession 1874
Gene Symbol CFL1 Alias CFL;cofilin;HEL-S-15 Full Name cofilin 1
Position 11 : 65854673 - 65862026 Length 7354 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]

ENSG00000172757 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000172757 CFL1 0.63 4.44e-12 HNSC
ENSG00000172757 CFL1 1.02 8.33e-73 BRCA
ENSG00000172757 CFL1 0.80 1.61e-19 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000172757 CFL1 tumour 12922171
ENSG00000172757 CFL1 breast cancer 17272681
ENSG00000172757 CFL1 colon cancer 17583572
ENSG00000172757 CFL1 tumors 18401453
ENSG00000172757 CFL1 tumours 18544163
ENSG00000172757 CFL1 HNSCC 18617144
ENSG00000172757 CFL1 metastatic cancer 18821527
ENSG00000172757 CFL1 tumor 19483720
ENSG00000172757 CFL1 cancer 20095995
ENSG00000172757 CFL1 breast cancers 20133759
ENSG00000172757 CFL1 nonsmall cell lung cancer 20564088
ENSG00000172757 CFL1 tumour 20713416
ENSG00000172757 CFL1 breast cancer 20819441
ENSG00000172757 CFL1 epithelial ovarian cancer 21237490
ENSG00000172757 CFL1 non-small cell lung cancer 21735353
ENSG00000172757 CFL1 pancreatic cancer 21894436
ENSG00000172757 CFL1 tumor 22087286
ENSG00000172757 CFL1 tumors 22742733
ENSG00000172757 CFL1 prostate cancer 22858003
ENSG00000172757 CFL1 ovarian cancer 23064469
ENSG00000172757 CFL1 epithelial ovarian cancer 23205117
ENSG00000172757 CFL1 tumors 23227181
ENSG00000172757 CFL1 tumors 23302599
ENSG00000172757 CFL1 tumor 23320827
ENSG00000172757 CFL1 cancer 23362981
ENSG00000172757 CFL1 tumor 23957735
ENSG00000172757 CFL1 tumor 24023293
ENSG00000172757 CFL1 breast tumor 24093776
ENSG00000172757 CFL1 tumor 24106833
ENSG00000172757 CFL1 tumor 24187485
ENSG00000172757 CFL1 gastric cancer 24197982
ENSG00000172757 CFL1 breast cancer 24505128
ENSG00000172757 CFL1 prostate cancer 24509905
ENSG00000172757 CFL1 Colon Cancer 24682035
ENSG00000172757 CFL1 tumor 25019393
ENSG00000172757 CFL1 brain tumor 25237832
ENSG00000172757 CFL1 breast cancer 25454514
ENSG00000172757 CFL1 gastric cancer 25520072
ENSG00000172757 CFL1 colon cancer 25529407
ENSG00000172757 CFL1 cancer 25597880
ENSG00000172757 CFL1 tumor 25679223
ENSG00000172757 CFL1 cancer 25689427
ENSG00000172757 CFL1 non-small-cell lung cancer 25784483
ENSG00000172757 CFL1 cancer 26008973
ENSG00000172757 CFL1 prostate cancer 26137141
ENSG00000172757 CFL1 tumor 26344167
ENSG00000172757 CFL1 colorectal cancer 26452645
ENSG00000172757 CFL1 breast cancer 26620550
ENSG00000172757 CFL1 gastric cancer 26871290
ENSG00000172757 CFL1 cancer 26936386
ENSG00000172757 CFL1 papillary thyroid cancer 27003257
ENSG00000172757 CFL1 prostate cancer 27035282
ENSG00000172757 CFL1 tumors 27128972
ENSG00000172757 CFL1 tumor 27206672
ENSG00000172757 CFL1 lung cancer 27496138
ENSG00000172757 CFL1 cancer 27567007
ENSG00000172757 CFL1 breast cancer 27626171
ENSG00000172757 CFL1 prostate cancer 27698874
ENSG00000172757 CFL1 prostate cancer 27711093
ENSG00000172757 CFL1 tumor 27748761
ENSG00000172757 CFL1 bladder cancer 27768223
ENSG00000172757 CFL1 Gastric Cancer 27872653
ENSG00000172757 CFL1 breast cancer 27880729
ENSG00000172757 CFL1 cancer 28161904
ENSG00000172757 CFL1 tumor 28216224
ENSG00000172757 CFL1 tumors 28388575
ENSG00000172757 CFL1 prostate cancer 28423713
ENSG00000172757 CFL1 prostate cancer 28599494
ENSG00000172757 CFL1 GBM 28679472
ENSG00000172757 CFL1 ovarian cancer 28857608
ENSG00000172757 CFL1 tumor 28903403
ENSG00000172757 CFL1 gastric cancer 28927046
ENSG00000172757 CFL1 breast cancer 29156719
ENSG00000172757 CFL1 breast cancer 29188531
ENSG00000172757 CFL1 bladder cancer 29190896
ENSG00000172757 CFL1 tumor 29347944
ENSG00000172757 CFL1 tumor 29371635
ENSG00000172757 CFL1 breast cancer 29434713
ENSG00000172757 CFL1 prostate cancer 29435058
ENSG00000172757 CFL1 tumor 29507663
ENSG00000172757 CFL1 cancer 29581975
ENSG00000172757 CFL1 cancer 29844875
ENSG00000172757 CFL1 lung cancer 29846436
ENSG00000172757 CFL1 prostate cancer 30008891
ENSG00000172757 CFL1 endometrial cancer 30036538
ENSG00000172757 CFL1 oral cancer 30144841
ENSG00000172757 CFL1 prostate cancer 30250560
ENSG00000172757 CFL1 cancer 30287810
ENSG00000172757 CFL1 colorectal cancer 30296500
ENSG00000172757 CFL1 breast cancer 30320377
ENSG00000172757 CFL1 tumor 30361512
ENSG00000172757 CFL1 tumor 30390003
ENSG00000172757 CFL1 tumor 30477310
ENSG00000172757 CFL1 colorectal cancer 30505577
ENSG00000172757 CFL1 gastric cancer 30622602
ENSG00000172757 CFL1 tumor 30858759
ENSG00000172757 CFL1 gastric cancer 30910056
ENSG00000172757 CFL1 breast cancer 31078043
ENSG00000172757 CFL1 colorectal cancer 31097925
ENSG00000172757 CFL1 tumors 31169331
ENSG00000172757 CFL1 oral cancer 31359510
ENSG00000172757 CFL1 tumor 31427165
ENSG00000172757 CFL1 tumor 31442208
ENSG00000172757 CFL1 Epithelial Ovarian Cancer 31700829
ENSG00000172757 CFL1 cancers 31735913
ENSG00000172757 CFL1 liver cancer 31988091
ENSG00000172757 CFL1 gastric cancer 31990066
ENSG00000172757 CFL1 pancreatic cancer PMC4669991
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000172757 CFL1 STAD 0.019 low
ENSG00000172757 CFL1 UVM 0.018 high
ENSG00000172757 CFL1 PAAD 0.0052 high
ENSG00000172757 CFL1 UCEC 0.0029 high
ENSG00000172757 CFL1 HNSC 0.026 high
ENSG00000172757 CFL1 KICH 0.0077 high
ENSG00000172757 CFL1 LUAD 0.00037 high
ENSG00000172757 CFL1 THYM 0.0052 low
ENSG00000172757 CFL1 COAD 0.0037 low
ENSG00000172757 CFL1 UCS 0.004 low
ENSG00000172757 CFL1 OV 0.0061 low
ENSG00000172757 CFL1 KIRC 6e-04 high
ENSG00000172757 CFL1 PRAD 0.039 high
ENSG00000172757 CFL1 GBM 0.026 high
ENSG00000172757 CFL1 SKCM 0.0095 high
ENSG00000172757 CFL1 CESC 0.0035 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000172757 CFL1 SKCM Del 0.941250 0.070505 0.446056 0.354223
ENSG00000172757 CFL1 BRCA Del 4.914250 0.092226 0.439424 0.225000