Ensembl ID ENSG00000172590 Gene ID 122704 Accession 16655
Gene Symbol MRPL52 Alias mL52 Full Name mitochondrial ribosomal protein L52
Position 14 : 22829883 - 22835037 Length 5155 bases Strand Plus strand
Status Confidence Main interacting RNAsrRNARBP type Non-canonical_RBPs
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which has no bacterial homolog. Multiple transcript variants encoding different protein isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

ENSG00000172590 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000172590 MRPL52 0.70 7.40e-24 BRCA
ENSG00000172590 MRPL52 0.71 6.42e-14 LUSC
ENSG00000172590 MRPL52 0.99 1.08e-13 UCEC
ENSG00000172590 MRPL52 0.78 6.69e-16 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000172590 MRPL52 UCEC 0.026 high
ENSG00000172590 MRPL52 ACC 0.0026 high
ENSG00000172590 MRPL52 LGG 0.00041 low
ENSG00000172590 MRPL52 LUSC 0.018 low
ENSG00000172590 MRPL52 HNSC 0.045 high
ENSG00000172590 MRPL52 READ 0.033 high
ENSG00000172590 MRPL52 KIRP 0.002 low
ENSG00000172590 MRPL52 LUAD 0.018 high
ENSG00000172590 MRPL52 ESCA 0.037 high
ENSG00000172590 MRPL52 OV 0.0083 low
ENSG00000172590 MRPL52 DLBC 0.038 low
ENSG00000172590 MRPL52 TGCT 0.047 low
ENSG00000172590 MRPL52 SKCM 0.023 high
ENSG00000172590 MRPL52 LIHC 0.0016 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000172590 MRPL52 LUSC Del 1.052185 0.070880 0.359998 0.347305
ENSG00000172590 MRPL52 LUAD Amp 1.996953 0.149261 0.448638 0.327519
ENSG00000172590 MRPL52 ACC Amp 0.881753 0.269326 1.094370 0.300000
ENSG00000172590 MRPL52 READ Del 0.637830 0.068896 0.485108 0.412121
ENSG00000172590 MRPL52 GBM Del 5.880216 0.099071 0.599442 0.298094
ENSG00000172590 MRPL52 HNSC Del 2.366920 0.071762 0.425795 0.147510