Ensembl ID ENSG00000172531 Gene ID 5499 Accession 9281
Gene Symbol PPP1CA Alias PP1A;PP-1A;PPP1A;PP1alpha Full Name protein phosphatase 1 catalytic subunit alpha
Position 11 : 67398183 - 67401871 Length 3689 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity. PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of cancer. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]

ENSG00000172531 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000172531 PPP1CA 1.12 3.54e-67 BRCA
ENSG00000172531 PPP1CA 1.48 5.77e-48 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000172531 PPP1CA cancers 1684084
ENSG00000172531 PPP1CA tumors 18204081
ENSG00000172531 PPP1CA tumor 20663907
ENSG00000172531 PPP1CA bladder cancer 21106093
ENSG00000172531 PPP1CA cancer 21847129
ENSG00000172531 PPP1CA ovarian cancer 21909427
ENSG00000172531 PPP1CA gastric cancer 25240408
ENSG00000172531 PPP1CA cancer 25252636
ENSG00000172531 PPP1CA tumor 26253838
ENSG00000172531 PPP1CA cancer 26387546
ENSG00000172531 PPP1CA tumor 26677227
ENSG00000172531 PPP1CA cancer 26962435
ENSG00000172531 PPP1CA tumor 27462467
ENSG00000172531 PPP1CA GBM 27606302
ENSG00000172531 PPP1CA head and neck cancer 28262749
ENSG00000172531 PPP1CA gastric cancer 28672982
ENSG00000172531 PPP1CA lung cancer 29285244
ENSG00000172531 PPP1CA cancer 30013629
ENSG00000172531 PPP1CA Cancer 30158517
ENSG00000172531 PPP1CA tumor 30912184
ENSG00000172531 PPP1CA colon cancer 30980866
ENSG00000172531 PPP1CA colorectal cancer 31521612
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000172531 PPP1CA MESO 0.033 high
ENSG00000172531 PPP1CA UVM 0.019 high
ENSG00000172531 PPP1CA PAAD 0.0065 high
ENSG00000172531 PPP1CA ACC 0.00029 high
ENSG00000172531 PPP1CA HNSC 0.02 high
ENSG00000172531 PPP1CA LUAD 0.025 high
ENSG00000172531 PPP1CA THYM 0.009 low
ENSG00000172531 PPP1CA BRCA 0.025 low
ENSG00000172531 PPP1CA COAD 0.019 low
ENSG00000172531 PPP1CA UCS 0.047 high
ENSG00000172531 PPP1CA ESCA 0.019 low
ENSG00000172531 PPP1CA OV 0.032 low
ENSG00000172531 PPP1CA BLCA 0.042 low
ENSG00000172531 PPP1CA LAML 0.0049 high
ENSG00000172531 PPP1CA CESC 0.0099 low
ENSG00000172531 PPP1CA LIHC 0.0029 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000172531 PPP1CA LUAD Amp 1.891125 0.147118 0.418566 0.321705
ENSG00000172531 PPP1CA CESC Amp 2.856714 0.206960 0.630461 0.145763
ENSG00000172531 PPP1CA ESCA Amp 3.373769 0.405654 0.610265 0.375000
ENSG00000172531 PPP1CA SKCM Amp 3.738558 0.209688 0.725061 0.158038
ENSG00000172531 PPP1CA HNSC Amp 21.986529 0.421758 0.642906 0.344828
ENSG00000172531 PPP1CA LIHC Amp 2.006004 0.146260 0.774540 0.105405
ENSG00000172531 PPP1CA BLCA Amp 2.845647 0.234870 0.502986 0.272059
ENSG00000172531 PPP1CA BRCA Amp 42.397499 0.502286 0.867332 0.281481
ENSG00000172531 PPP1CA STAD Amp 1.490264 0.155795 0.517661 0.219955
ENSG00000172531 PPP1CA PRAD Amp 4.581163 0.099206 0.615180 0.097561
ENSG00000172531 PPP1CA UCEC Amp 4.659746 0.177456 0.649056 0.139147