Ensembl ID ENSG00000172053 Gene ID 5859 Accession 9751
Gene Symbol QARS1 Alias QARS;GLNRS;MSCCA;PRO2195 Full Name glutaminyl-tRNA synthetase 1
Position 3 : 49095932 - 49105130 Length 9199 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

ENSG00000172053 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000172053 QARS1 -0.3 8.08e-12 KIRC
ENSG00000172053 QARS1 -0.9 6.66e-35 HNSC
ENSG00000172053 QARS1 0.43 2.88e-12 PRAD
ENSG00000172053 QARS1 0.63 6.71e-15 LIHC
ENSG00000172053 QARS1 0.65 2.70e-13 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000172053 QARS1 SARC 0.00016 high
ENSG00000172053 QARS1 STAD 0.0039 low
ENSG00000172053 QARS1 UCEC 0.00096 low
ENSG00000172053 QARS1 THCA 0.027 high
ENSG00000172053 QARS1 ACC 0.0022 high
ENSG00000172053 QARS1 HNSC 0.0053 low
ENSG00000172053 QARS1 READ 0.021 high
ENSG00000172053 QARS1 LUAD 0.0054 low
ENSG00000172053 QARS1 PCPG 0.0097 low
ENSG00000172053 QARS1 THYM 0.0021 low
ENSG00000172053 QARS1 COAD 0.02 low
ENSG00000172053 QARS1 ESCA 0.021 high
ENSG00000172053 QARS1 DLBC 0.036 low
ENSG00000172053 QARS1 KIRC 0.018 high
ENSG00000172053 QARS1 PRAD 0.042 high
ENSG00000172053 QARS1 GBM 0.015 low
ENSG00000172053 QARS1 SKCM 0.0058 high
ENSG00000172053 QARS1 CESC 0.0032 low
ENSG00000172053 QARS1 LIHC 0.0084 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000172053 QARS1 CHOL Del 1.097134 0.240589 0.628335 0.833333
ENSG00000172053 QARS1 LUSC Del 3.401717 0.098108 0.411432 0.864271
ENSG00000172053 QARS1 LUAD Del 1.551434 0.062525 0.324149 0.480620
ENSG00000172053 QARS1 LGG Del 2.365071 0.055504 0.515147 0.091618
ENSG00000172053 QARS1 READ Del 0.952952 0.079394 0.426265 0.157576
ENSG00000172053 QARS1 COAD Del 1.236767 0.048491 0.427069 0.155211
ENSG00000172053 QARS1 UCS Del 2.537879 0.340261 0.544793 0.589286
ENSG00000172053 QARS1 SARC Del 2.101399 0.159659 0.531011 0.252918
ENSG00000172053 QARS1 ESCA Del 1.583820 0.121798 0.444812 0.657609
ENSG00000172053 QARS1 HNSC Del 0.958465 0.057451 0.434930 0.720307
ENSG00000172053 QARS1 BLCA Del 6.049487 0.144088 0.415771 0.291667
ENSG00000172053 QARS1 BRCA Del 28.191647 0.172021 0.460200 0.315741
ENSG00000172053 QARS1 STAD Del 5.970306 0.116612 0.348310 0.340136
ENSG00000172053 QARS1 UCEC Del 1.022368 0.052224 0.483459 0.126160
ENSG00000172053 QARS1 MESO Del 16.697086 0.532614 0.567339 0.505747
ENSG00000172053 QARS1 KIRC Del 50.641217 0.179006 0.515750 0.880682
ENSG00000172053 QARS1 OV Del 1.687880 0.196709 0.479215 0.329879