Ensembl ID ENSG00000171865 Gene ID 246243 Accession 18466
Gene Symbol RNASEH1 Alias RNH1;H1RNA;PEOB2 Full Name ribonuclease H1
Position 2 : 3541430 - 3558333 Length 16904 bases Strand Minus strand
Status Confidence Main interacting RNAsdiverseRBP type Canonical_RBPs
Summary This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and plays a key role in DNA replication and repair. Alternate in-frame start codon initiation results in the production of alternate isoforms that are directed to the mitochondria or to the nucleus. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF). Mutations in this gene have been found in individuals with progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2. Alternative splicing results in additional coding and non-coding transcript variants. Pseudogenes of this gene have been defined on chromosomes 2 and 17. [provided by RefSeq, Jul 2017]

ENSG00000171865 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000171865 RNASEH1 0.55 2.50e-19 COAD
ENSG00000171865 RNASEH1 0.98 5.76e-46 LUSC
ENSG00000171865 RNASEH1 0.48 9.53e-11 LIHC
ENSG00000171865 RNASEH1 0.78 1.52e-12 UCEC
ENSG00000171865 RNASEH1 0.57 9.39e-17 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000171865 RNASEH1 prostate cancer 11856317
ENSG00000171865 RNASEH1 tumour 25330849
ENSG00000171865 RNASEH1 breast cancer 27720940
ENSG00000171865 RNASEH1 Cancer 27725641
ENSG00000171865 RNASEH1 cancer 30591567
ENSG00000171865 RNASEH1 cancer 31174564
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000171865 RNASEH1 MESO 0.00066 high
ENSG00000171865 RNASEH1 STAD 0.037 low
ENSG00000171865 RNASEH1 PAAD 0.0013 high
ENSG00000171865 RNASEH1 UCEC 0.00088 high
ENSG00000171865 RNASEH1 THCA 0.029 high
ENSG00000171865 RNASEH1 LUSC 0.021 low
ENSG00000171865 RNASEH1 READ 0.03 low
ENSG00000171865 RNASEH1 KIRP 0.032 low
ENSG00000171865 RNASEH1 KICH 0.00042 high
ENSG00000171865 RNASEH1 LUAD 0.013 high
ENSG00000171865 RNASEH1 PCPG 0.031 low
ENSG00000171865 RNASEH1 COAD 0.043 low
ENSG00000171865 RNASEH1 DLBC 0.026 low
ENSG00000171865 RNASEH1 BLCA 0.0014 high
ENSG00000171865 RNASEH1 LAML 0.016 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000171865 RNASEH1 TGCT Amp 1.308797 0.145005 0.442904 0.380000