Ensembl ID
ENSG00000171311
Gene ID
51013
Accession
17286
Gene Symbol
EXOSC1
Alias
p13;CSL4;SKI4;Csl4p;PCH1F;Ski4p;CGI-108
Full Name
exosome component 1
Position
10 : 97435909 - 97446017
Length
10109 bases
Strand
Minus strand
Status
Confidence
Main interacting RNAs diverse RBP type
Canonical_RBPs
Summary
This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2016]
ENSG00000171311 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000171311
EXOSC1
0.51
1.22e-27
BRCA
ENSG00000171311
EXOSC1
0.52
3.40e-14
LUSC
ENSG00000171311
EXOSC1
0.64
2.46e-12
UCEC
ENSG00000171311
EXOSC1
0.59
6.59e-21
LUAD
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000171311
EXOSC1
SARC
0.0025
high
show
ENSG00000171311
EXOSC1
STAD
0.039
low
show
ENSG00000171311
EXOSC1
UVM
0.0036
high
show
ENSG00000171311
EXOSC1
UCEC
0.008
low
show
ENSG00000171311
EXOSC1
THCA
0.011
low
show
ENSG00000171311
EXOSC1
LUSC
0.0095
low
show
ENSG00000171311
EXOSC1
HNSC
0.013
high
show
ENSG00000171311
EXOSC1
READ
0.00023
high
show
ENSG00000171311
EXOSC1
KIRP
7e-04
high
show
ENSG00000171311
EXOSC1
THYM
0.05
low
show
ENSG00000171311
EXOSC1
BRCA
0.011
low
show
ENSG00000171311
EXOSC1
ESCA
0.025
high
show
ENSG00000171311
EXOSC1
BLCA
0.047
low
show
ENSG00000171311
EXOSC1
LAML
0.024
low
show
ENSG00000171311
EXOSC1
GBM
0.0067
low
show
ENSG00000171311
EXOSC1
SKCM
0.046
high
show
ENSG00000171311
EXOSC1
CESC
0.0047
low
show
ENSG00000171311
EXOSC1
LIHC
0.005
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000171311
EXOSC1
LUSC
Del
1.197372
0.073041
0.360708
0.528942
ENSG00000171311
EXOSC1
LGG
Del
1.247339
0.044952
0.557549
0.222222
ENSG00000171311
EXOSC1
CESC
Del
0.727877
0.067161
0.438612
0.298305
ENSG00000171311
EXOSC1
COAD
Del
6.966901
0.094102
0.397102
0.232816
ENSG00000171311
EXOSC1
GBM
Del
0.835212
0.053663
0.694881
0.875217
ENSG00000171311
EXOSC1
HNSC
Del
1.054167
0.058695
0.341330
0.256705
ENSG00000171311
EXOSC1
LIHC
Del
0.605003
0.063203
0.471823
0.262162
ENSG00000171311
EXOSC1
BLCA
Del
1.468500
0.090221
0.391538
0.409314
ENSG00000171311
EXOSC1
BRCA
Del
3.141902
0.082301
0.373442
0.293519
ENSG00000171311
EXOSC1
STAD
Del
2.701978
0.086661
0.372357
0.233560
ENSG00000171311
EXOSC1
PRAD
Del
3.373771
0.101663
0.441744
0.168699
ENSG00000171311
EXOSC1
UCEC
Del
6.154104
0.096615
0.550540
0.142857
ENSG00000171311
EXOSC1
MESO
Del
1.599660
0.160531
0.495729
0.333333
ENSG00000171311
EXOSC1
OV
Del
13.839673
0.334144
0.564284
0.424870
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