Ensembl ID
ENSG00000170892
Gene ID
79042
Accession
15506
Gene Symbol
TSEN34
Alias
LENG5;PCH2C;SEN34;SEN34L
Full Name
tRNA splicing endonuclease subunit 34
Position
19 : 54189938 - 54194536
Length
4599 bases
Strand
Plus strand
Status
Confidence
Main interacting RNAs tRNA RBP type
Canonical_RBPs
Summary
This gene encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Oct 2009]
ENSG00000170892 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000170892
TSEN34
0.88
1.06e-47
BRCA
ENSG00000170892
TSEN34
0.59
6.60e-16
LUSC
ENSG00000170892
TSEN34
1.26
6.99e-11
GBM
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000170892
TSEN34
MESO
0.0026
high
show
ENSG00000170892
TSEN34
SARC
0.0012
high
show
ENSG00000170892
TSEN34
STAD
0.0012
low
show
ENSG00000170892
TSEN34
PAAD
0.0043
low
show
ENSG00000170892
TSEN34
UCEC
0.01
high
show
ENSG00000170892
TSEN34
ACC
0.017
high
show
ENSG00000170892
TSEN34
LGG
0.00014
high
show
ENSG00000170892
TSEN34
KIRP
0.0012
high
show
ENSG00000170892
TSEN34
KICH
0.049
high
show
ENSG00000170892
TSEN34
THYM
0.00049
high
show
ENSG00000170892
TSEN34
BRCA
0.046
low
show
ENSG00000170892
TSEN34
UCS
0.031
high
show
ENSG00000170892
TSEN34
ESCA
0.021
high
show
ENSG00000170892
TSEN34
KIRC
0.0069
high
show
ENSG00000170892
TSEN34
LAML
0.0011
high
show
ENSG00000170892
TSEN34
GBM
0.037
low
show
ENSG00000170892
TSEN34
SKCM
0.00019
high
show
ENSG00000170892
TSEN34
CESC
0.049
low
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000170892
TSEN34
LUSC
Del
2.523686
0.089248
0.370984
0.255489
ENSG00000170892
TSEN34
LGG
Del
24.889932
0.173899
0.664985
0.530214
ENSG00000170892
TSEN34
CESC
Amp
0.871705
0.135263
0.586661
0.315254
ENSG00000170892
TSEN34
SARC
Del
2.203547
0.161766
0.433623
0.315175
ENSG00000170892
TSEN34
GBM
Del
9.417180
0.121775
0.523820
0.147314
ENSG00000170892
TSEN34
TGCT
Del
1.074585
0.064959
0.340103
0.380000
ENSG00000170892
TSEN34
BLCA
Amp
1.137569
0.180607
0.471518
0.394608
ENSG00000170892
TSEN34
BRCA
Amp
0.925164
0.150095
0.505944
0.249074
ENSG00000170892
TSEN34
OV
Del
8.144006
0.281788
0.567318
0.457686
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