Ensembl ID ENSG00000170892 Gene ID 79042 Accession 15506
Gene Symbol TSEN34 Alias LENG5;PCH2C;SEN34;SEN34L Full Name tRNA splicing endonuclease subunit 34
Position 19 : 54189938 - 54194536 Length 4599 bases Strand Plus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary This gene encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Oct 2009]

ENSG00000170892 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000170892 TSEN34 0.88 1.06e-47 BRCA
ENSG00000170892 TSEN34 0.59 6.60e-16 LUSC
ENSG00000170892 TSEN34 1.26 6.99e-11 GBM
Ensembl ID Gene symbol Cancer types Pubmed ID
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000170892 TSEN34 MESO 0.0026 high
ENSG00000170892 TSEN34 SARC 0.0012 high
ENSG00000170892 TSEN34 STAD 0.0012 low
ENSG00000170892 TSEN34 PAAD 0.0043 low
ENSG00000170892 TSEN34 UCEC 0.01 high
ENSG00000170892 TSEN34 ACC 0.017 high
ENSG00000170892 TSEN34 LGG 0.00014 high
ENSG00000170892 TSEN34 KIRP 0.0012 high
ENSG00000170892 TSEN34 KICH 0.049 high
ENSG00000170892 TSEN34 THYM 0.00049 high
ENSG00000170892 TSEN34 BRCA 0.046 low
ENSG00000170892 TSEN34 UCS 0.031 high
ENSG00000170892 TSEN34 ESCA 0.021 high
ENSG00000170892 TSEN34 KIRC 0.0069 high
ENSG00000170892 TSEN34 LAML 0.0011 high
ENSG00000170892 TSEN34 GBM 0.037 low
ENSG00000170892 TSEN34 SKCM 0.00019 high
ENSG00000170892 TSEN34 CESC 0.049 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000170892 TSEN34 LUSC Del 2.523686 0.089248 0.370984 0.255489
ENSG00000170892 TSEN34 LGG Del 24.889932 0.173899 0.664985 0.530214
ENSG00000170892 TSEN34 CESC Amp 0.871705 0.135263 0.586661 0.315254
ENSG00000170892 TSEN34 SARC Del 2.203547 0.161766 0.433623 0.315175
ENSG00000170892 TSEN34 GBM Del 9.417180 0.121775 0.523820 0.147314
ENSG00000170892 TSEN34 TGCT Del 1.074585 0.064959 0.340103 0.380000
ENSG00000170892 TSEN34 BLCA Amp 1.137569 0.180607 0.471518 0.394608
ENSG00000170892 TSEN34 BRCA Amp 0.925164 0.150095 0.505944 0.249074
ENSG00000170892 TSEN34 OV Del 8.144006 0.281788 0.567318 0.457686