Ensembl ID ENSG00000170515 Gene ID 5036 Accession 8550
Gene Symbol PA2G4 Alias EBP1;HG4-1;ITAF45;p38-2G4 Full Name proliferation-associated 2G4
Position 12 : 56104537 - 56113910 Length 9374 bases Strand Plus strand
Status Confidence Main interacting RNAsrRNARBP type Non-canonical_RBPs
Summary This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]

ENSG00000170515 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000170515 PA2G4 0.40 1.26e-18 KIRC
ENSG00000170515 PA2G4 0.38 6.36e-14 BRCA
ENSG00000170515 PA2G4 0.82 3.59e-26 COAD
ENSG00000170515 PA2G4 0.88 3.05e-38 LUSC
ENSG00000170515 PA2G4 0.58 1.78e-13 KIRP
ENSG00000170515 PA2G4 0.72 3.28e-11 UCEC
ENSG00000170515 PA2G4 0.55 9.28e-13 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000170515 PA2G4 prostate cancer 12682367
ENSG00000170515 PA2G4 prostate cancer 16254079
ENSG00000170515 PA2G4 tumor 16468034
ENSG00000170515 PA2G4 breast cancer 16944931
ENSG00000170515 PA2G4 breast cancer 18355957
ENSG00000170515 PA2G4 prostate cancer 18852121
ENSG00000170515 PA2G4 breast cancer 19628254
ENSG00000170515 PA2G4 prostate cancer 19937055
ENSG00000170515 PA2G4 prostate cancer 20048076
ENSG00000170515 PA2G4 prostate cancer 20159994
ENSG00000170515 PA2G4 breast cancer 20379846
ENSG00000170515 PA2G4 colon cancer 20421926
ENSG00000170515 PA2G4 breast tumors 21085677
ENSG00000170515 PA2G4 cancer 21136724
ENSG00000170515 PA2G4 tumour 21624892
ENSG00000170515 PA2G4 prostate cancer 21965718
ENSG00000170515 PA2G4 tumor 22545159
ENSG00000170515 PA2G4 breast cancer 22576745
ENSG00000170515 PA2G4 tumor 23110497
ENSG00000170515 PA2G4 breast cancer 23242156
ENSG00000170515 PA2G4 bladder cancer 23283744
ENSG00000170515 PA2G4 breast cancer 23361053
ENSG00000170515 PA2G4 breast cancer 23840586
ENSG00000170515 PA2G4 tumor 24374663
ENSG00000170515 PA2G4 breast cancer 24530908
ENSG00000170515 PA2G4 cancers 24651434
ENSG00000170515 PA2G4 prostate cancer 24798454
ENSG00000170515 PA2G4 lung cancer 24998263
ENSG00000170515 PA2G4 tumor 25081333
ENSG00000170515 PA2G4 tumor 25154617
ENSG00000170515 PA2G4 prostate cancer 25876877
ENSG00000170515 PA2G4 cancer 25917452
ENSG00000170515 PA2G4 thyroid tumor 26008146
ENSG00000170515 PA2G4 hematopoietic cancer 26081906
ENSG00000170515 PA2G4 cancer 26088450
ENSG00000170515 PA2G4 gastric cancer 26100106
ENSG00000170515 PA2G4 tumor 26256794
ENSG00000170515 PA2G4 tumor 26813358
ENSG00000170515 PA2G4 cancer 27118868
ENSG00000170515 PA2G4 cancer 27130196
ENSG00000170515 PA2G4 tumor 27464702
ENSG00000170515 PA2G4 Cancer 28209614
ENSG00000170515 PA2G4 cervical cancer 28670312
ENSG00000170515 PA2G4 tumor 28673244
ENSG00000170515 PA2G4 breast cancer 29997943
ENSG00000170515 PA2G4 cancer 30076717
ENSG00000170515 PA2G4 tumor 30250408
ENSG00000170515 PA2G4 breast cancer 30339663
ENSG00000170515 PA2G4 cancers 30793766
ENSG00000170515 PA2G4 tumor 31086087
ENSG00000170515 PA2G4 tumour 31147722
ENSG00000170515 PA2G4 tumors 31501192
ENSG00000170515 PA2G4 gallbladder cancer 31752867
ENSG00000170515 PA2G4 esophageal cancer 31966354
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000170515 PA2G4 MESO 0.0013 high
ENSG00000170515 PA2G4 SARC 0.04 high
ENSG00000170515 PA2G4 PAAD 0.027 high
ENSG00000170515 PA2G4 UCEC 0.012 low
ENSG00000170515 PA2G4 LGG 0.0011 low
ENSG00000170515 PA2G4 LUSC 0.02 low
ENSG00000170515 PA2G4 HNSC 0.0056 high
ENSG00000170515 PA2G4 KICH 0.0063 high
ENSG00000170515 PA2G4 BRCA 0.01 high
ENSG00000170515 PA2G4 ESCA 0.005 high
ENSG00000170515 PA2G4 OV 0.0036 low
ENSG00000170515 PA2G4 DLBC 0.0059 low
ENSG00000170515 PA2G4 PRAD 0.018 low
ENSG00000170515 PA2G4 LAML 0.028 high
ENSG00000170515 PA2G4 SKCM 0.00065 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000170515 PA2G4 UCS Amp 1.084949 0.557694 0.655419 0.464286
ENSG00000170515 PA2G4 STAD Amp 2.796061 0.189535 0.543590 0.244898
ENSG00000170515 PA2G4 UCEC Amp 7.268651 0.213216 0.683678 0.189239