Ensembl ID ENSG00000170365 Gene ID 4086 Accession 6767
Gene Symbol SMAD1 Alias BSP1;JV41;BSP-1;JV4-1;MADH1;MADR1 Full Name SMAD family member 1
Position 4 : 145481194 - 145559176 Length 77983 bases Strand Plus strand
Status Confidence Main interacting RNAsncRNARBP type Non-canonical_RBPs
Summary The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

ENSG00000170365 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000170365 SMAD1 -0.6 3.52e-18 COAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000170365 SMAD1 tumor 10389752
ENSG00000170365 SMAD1 colorectal cancer 10446110
ENSG00000170365 SMAD1 tumor 10564585
ENSG00000170365 SMAD1 germ cell tumors 10706106
ENSG00000170365 SMAD1 tumors 11313978
ENSG00000170365 SMAD1 tumor 11517183
ENSG00000170365 SMAD1 breast cancer 11786386
ENSG00000170365 SMAD1 DLBCL 12967475
ENSG00000170365 SMAD1 breast cancer 15203941
ENSG00000170365 SMAD1 tumor 15470494
ENSG00000170365 SMAD1 tumors 15548366
ENSG00000170365 SMAD1 breast cancer 15892165
ENSG00000170365 SMAD1 tumour 16611366
ENSG00000170365 SMAD1 prostate cancer 16740653
ENSG00000170365 SMAD1 colon cancer 16769811
ENSG00000170365 SMAD1 prostate cancer 17183365
ENSG00000170365 SMAD1 breast cancer 17363596
ENSG00000170365 SMAD1 tumor 17455258
ENSG00000170365 SMAD1 prostate cancer 17496924
ENSG00000170365 SMAD1 myeloid tumor 17552911
ENSG00000170365 SMAD1 colon cancer 17942918
ENSG00000170365 SMAD1 metastatic tumor 17967875
ENSG00000170365 SMAD1 tumours 18310289
ENSG00000170365 SMAD1 cancer 18663362
ENSG00000170365 SMAD1 tumor 18794361
ENSG00000170365 SMAD1 pancreatic cancer 19056927
ENSG00000170365 SMAD1 tumors 19094238
ENSG00000170365 SMAD1 tumor 19290004
ENSG00000170365 SMAD1 tumor 19429390
ENSG00000170365 SMAD1 GBM 19587783
ENSG00000170365 SMAD1 tumor 19773112
ENSG00000170365 SMAD1 granulosa cell tumors 19819941
ENSG00000170365 SMAD1 ovarian cancer 19996292
ENSG00000170365 SMAD1 tumor 20054823
ENSG00000170365 SMAD1 tumor 20309962
ENSG00000170365 SMAD1 granulosa cell tumor 20363875
ENSG00000170365 SMAD1 tumor 20937357
ENSG00000170365 SMAD1 rectal cancer 21068203
ENSG00000170365 SMAD1 renal cell cancer 21302714
ENSG00000170365 SMAD1 cancers 21318824
ENSG00000170365 SMAD1 invasive breast cancer 21527583
ENSG00000170365 SMAD1 prostate cancer 22452883
ENSG00000170365 SMAD1 tumors 22581056
ENSG00000170365 SMAD1 gastric cancer 22588298
ENSG00000170365 SMAD1 tumors 22964636
ENSG00000170365 SMAD1 Tumor 23049692
ENSG00000170365 SMAD1 tumors 23088614
ENSG00000170365 SMAD1 tumor 23209720
ENSG00000170365 SMAD1 cancer 23676460
ENSG00000170365 SMAD1 prostate cancer 23734213
ENSG00000170365 SMAD1 cancer 23807047
ENSG00000170365 SMAD1 liver cancer 23936038
ENSG00000170365 SMAD1 cancer 24021264
ENSG00000170365 SMAD1 tumor 24142423
ENSG00000170365 SMAD1 tumor 24185914
ENSG00000170365 SMAD1 cancer 24308972
ENSG00000170365 SMAD1 tumor 24618373
ENSG00000170365 SMAD1 tumor 24705250
ENSG00000170365 SMAD1 non-small-cell lung cancer 25003810
ENSG00000170365 SMAD1 tumors 25010525
ENSG00000170365 SMAD1 breast cancer 25070479
ENSG00000170365 SMAD1 breast cancer 25077702
ENSG00000170365 SMAD1 tumor 25141865
ENSG00000170365 SMAD1 tumor 25243859
ENSG00000170365 SMAD1 HNSCC 25471937
ENSG00000170365 SMAD1 tumor 25623554
ENSG00000170365 SMAD1 colorectal cancers 25757624
ENSG00000170365 SMAD1 tumors 25860932
ENSG00000170365 SMAD1 tumors 26018516
ENSG00000170365 SMAD1 tumor 26029998
ENSG00000170365 SMAD1 prostate cancer 26227059
ENSG00000170365 SMAD1 tumors 26337467
ENSG00000170365 SMAD1 cancer 26678910
ENSG00000170365 SMAD1 non-small cell lung cancer 26701726
ENSG00000170365 SMAD1 tumor 26908439
ENSG00000170365 SMAD1 tumor 26910889
ENSG00000170365 SMAD1 tumors 26984046
ENSG00000170365 SMAD1 liver cancer 27027434
ENSG00000170365 SMAD1 lung cancer 27049088
ENSG00000170365 SMAD1 tumor 27104151
ENSG00000170365 SMAD1 gastric cancer 27113301
ENSG00000170365 SMAD1 colorectal cancer 27145365
ENSG00000170365 SMAD1 tumor 27186261
ENSG00000170365 SMAD1 breast cancer 27197181
ENSG00000170365 SMAD1 tumor 27429845
ENSG00000170365 SMAD1 Tumor 27466623
ENSG00000170365 SMAD1 tumors 27661009
ENSG00000170365 SMAD1 cancer 27903972
ENSG00000170365 SMAD1 tumor 28199984
ENSG00000170365 SMAD1 tumor 28202676
ENSG00000170365 SMAD1 tumours 28299802
ENSG00000170365 SMAD1 ovarian cancer 28357470
ENSG00000170365 SMAD1 lung cancer 28601662
ENSG00000170365 SMAD1 breast tumors 28721365
ENSG00000170365 SMAD1 DLBCL 28731456
ENSG00000170365 SMAD1 tumor 28771228
ENSG00000170365 SMAD1 liver cancer 28794048
ENSG00000170365 SMAD1 lung cancer 28852126
ENSG00000170365 SMAD1 tumors 28870287
ENSG00000170365 SMAD1 prostate cancer 28881744
ENSG00000170365 SMAD1 Tumor 29154973
ENSG00000170365 SMAD1 tumor 29156807
ENSG00000170365 SMAD1 cervical cancer 29180690
ENSG00000170365 SMAD1 GBM 29212066
ENSG00000170365 SMAD1 cancer 29219668
ENSG00000170365 SMAD1 sex cord-stromal tumors 29221447
ENSG00000170365 SMAD1 tumours 29260980
ENSG00000170365 SMAD1 colorectal cancer 29299158
ENSG00000170365 SMAD1 breast cancer 29376829
ENSG00000170365 SMAD1 tumors 29409506
ENSG00000170365 SMAD1 tumor 29535220
ENSG00000170365 SMAD1 tumor 29615404
ENSG00000170365 SMAD1 cancer 29780169
ENSG00000170365 SMAD1 tumor 29799303
ENSG00000170365 SMAD1 cancer 29934328
ENSG00000170365 SMAD1 AML 30177817
ENSG00000170365 SMAD1 DLBCL 30308041
ENSG00000170365 SMAD1 colon cancer 30426548
ENSG00000170365 SMAD1 breast cancer 30554919
ENSG00000170365 SMAD1 breast cancer 30674353
ENSG00000170365 SMAD1 cancer 30764831
ENSG00000170365 SMAD1 prostate cancer 30808576
ENSG00000170365 SMAD1 cancer 31108028
ENSG00000170365 SMAD1 cancer 31189127
ENSG00000170365 SMAD1 breast cancer 31222004
ENSG00000170365 SMAD1 cancer 31431542
ENSG00000170365 SMAD1 colon cancer 31545230
ENSG00000170365 SMAD1 breast cancer 31547567
ENSG00000170365 SMAD1 ovarian cancer 31576147
ENSG00000170365 SMAD1 tumor 31586903
ENSG00000170365 SMAD1 tumor 31648327
ENSG00000170365 SMAD1 tumor 31858559
ENSG00000170365 SMAD1 pancreatic cancer 8637600
ENSG00000170365 SMAD1 tumour 8893010
ENSG00000170365 SMAD1 tumor 9436979
ENSG00000170365 SMAD1 breast cancer 9788633
ENSG00000170365 SMAD1 cervical cancer 9865919
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000170365 SMAD1 MESO 0.03 high
ENSG00000170365 SMAD1 SARC 0.0017 high
ENSG00000170365 SMAD1 CHOL 0.013 low
ENSG00000170365 SMAD1 UVM 0.035 high
ENSG00000170365 SMAD1 PAAD 0.023 high
ENSG00000170365 SMAD1 THCA 0.00065 high
ENSG00000170365 SMAD1 HNSC 0.044 low
ENSG00000170365 SMAD1 READ 0.0049 low
ENSG00000170365 SMAD1 KICH 0.022 high
ENSG00000170365 SMAD1 LUAD 0.0079 low
ENSG00000170365 SMAD1 PCPG 0.023 low
ENSG00000170365 SMAD1 OV 0.036 high
ENSG00000170365 SMAD1 PRAD 0.027 high
ENSG00000170365 SMAD1 BLCA 0.02 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000170365 SMAD1 LUSC Del 3.305956 0.097244 0.386412 0.628743
ENSG00000170365 SMAD1 LGG Del 5.082327 0.075553 0.444769 0.241715
ENSG00000170365 SMAD1 BLCA Del 0.672553 0.075892 0.352238 0.379902
ENSG00000170365 SMAD1 STAD Del 0.673312 0.059902 0.326619 0.383220