Ensembl ID ENSG00000170348 Gene ID 10972 Accession 16998
Gene Symbol TMED10 Alias p23;TMP21;p24d1;S31I125;Tmp-21-I;S31III125;P24(DELTA) Full Name transmembrane p24 trafficking protein 10
Position 14 : 75131469 - 75176612 Length 45144 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]

ENSG00000170348 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000170348 TMED10 tumor 17684551
ENSG00000170348 TMED10 papillary thyroid cancer 26617795
ENSG00000170348 TMED10 tumor 28115518
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000170348 TMED10 MESO 0.018 low
ENSG00000170348 TMED10 SARC 0.027 high
ENSG00000170348 TMED10 UVM 0.00057 high
ENSG00000170348 TMED10 PAAD 0.0085 high
ENSG00000170348 TMED10 UCEC 0.0017 low
ENSG00000170348 TMED10 THCA 0.00017 high
ENSG00000170348 TMED10 ACC 0.024 high
ENSG00000170348 TMED10 HNSC 9e-04 high
ENSG00000170348 TMED10 KIRP 0.037 high
ENSG00000170348 TMED10 KICH 0.011 high
ENSG00000170348 TMED10 UCS 0.018 low
ENSG00000170348 TMED10 ESCA 0.025 low
ENSG00000170348 TMED10 OV 0.0069 low
ENSG00000170348 TMED10 DLBC 0.024 low
ENSG00000170348 TMED10 PRAD 0.0069 low
ENSG00000170348 TMED10 BLCA 0.017 high
ENSG00000170348 TMED10 LAML 0.042 high
ENSG00000170348 TMED10 SKCM 0.00033 low
ENSG00000170348 TMED10 CESC 0.02 high
ENSG00000170348 TMED10 LIHC 0.047 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000170348 TMED10 CHOL Del 1.574640 0.282692 0.597552 0.555556
ENSG00000170348 TMED10 LGG Del 11.949004 0.114807 0.550816 0.235867
ENSG00000170348 TMED10 SARC Del 0.629070 0.117533 0.558836 0.307393
ENSG00000170348 TMED10 GBM Del 3.197384 0.078431 0.599694 0.301560
ENSG00000170348 TMED10 LIHC Del 3.345959 0.102998 0.519003 0.345946
ENSG00000170348 TMED10 BRCA Del 6.769684 0.101248 0.422353 0.328704
ENSG00000170348 TMED10 KIRC Del 0.735446 0.024811 0.426814 0.433712
ENSG00000170348 TMED10 OV Del 0.779299 0.176141 0.529277 0.457686