Ensembl ID ENSG00000170004 Gene ID 1107 Accession 1918
Gene Symbol CHD3 Alias ZFH;Mi-2a;SNIBCPS;Mi2-ALPHA Full Name chromodomain helicase DNA binding protein 3
Position 17 : 7884796 - 7912760 Length 27965 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

ENSG00000170004 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000170004 CHD3 -1.0 6.23e-35 KIRC
ENSG00000170004 CHD3 2.69 1.10e-18 CHOL
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000170004 CHD3 AML 16849538
ENSG00000170004 CHD3 cancers 21447119
ENSG00000170004 CHD3 tumor 25025207
ENSG00000170004 CHD3 breast cancer 27572852
ENSG00000170004 CHD3 tumor 27863398
ENSG00000170004 CHD3 breast cancer 28055972
ENSG00000170004 CHD3 cancers 28649742
ENSG00000170004 CHD3 cancer 31221981
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000170004 CHD3 SARC 0.043 high
ENSG00000170004 CHD3 UVM 0.02 high
ENSG00000170004 CHD3 PAAD 0.0011 low
ENSG00000170004 CHD3 THCA 0.01 high
ENSG00000170004 CHD3 ACC 0.0037 high
ENSG00000170004 CHD3 HNSC 0.0092 low
ENSG00000170004 CHD3 KIRP 0.015 low
ENSG00000170004 CHD3 LUAD 0.049 high
ENSG00000170004 CHD3 THYM 0.036 low
ENSG00000170004 CHD3 BRCA 0.024 low
ENSG00000170004 CHD3 ESCA 0.045 low
ENSG00000170004 CHD3 OV 0.0043 high
ENSG00000170004 CHD3 PRAD 0.046 low
ENSG00000170004 CHD3 BLCA 0.0029 low
ENSG00000170004 CHD3 LAML 0.0058 high
ENSG00000170004 CHD3 GBM 0.04 high
ENSG00000170004 CHD3 SKCM 0.013 high
ENSG00000170004 CHD3 LIHC 0.025 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000170004 CHD3 LUAD Del 0.674855 0.050775 0.362826 0.536822
ENSG00000170004 CHD3 SARC Del 12.496429 0.326480 0.598670 0.412451
ENSG00000170004 CHD3 GBM Del 1.156061 0.057979 0.490688 0.150780
ENSG00000170004 CHD3 LIHC Del 9.410201 0.161227 0.662077 0.608108
ENSG00000170004 CHD3 BRCA Del 0.901388 0.065360 0.487437 0.603704
ENSG00000170004 CHD3 PRAD Del 28.853140 0.244917 0.551946 0.327236