Ensembl ID ENSG00000169564 Gene ID 5093 Accession 8647
Gene Symbol PCBP1 Alias HNRPX;HNRPE1;hnRNP-X;HEL-S-85;hnRNP-E1 Full Name poly(rC) binding protein 1
Position 2 : 70087477 - 70089203 Length 1727 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]

ENSG00000169564 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000169564 PCBP1 cancer 12890803
ENSG00000169564 PCBP1 tumor 17118157
ENSG00000169564 PCBP1 tumor 20361869
ENSG00000169564 PCBP1 prostate cancer 20519371
ENSG00000169564 PCBP1 primary cancers 20609352
ENSG00000169564 PCBP1 pancreatic cancer 20687567
ENSG00000169564 PCBP1 cancer 21654215
ENSG00000169564 PCBP1 gestational trophoblastic tumors 22801034
ENSG00000169564 PCBP1 cancers 23715860
ENSG00000169564 PCBP1 lung cancer 24819169
ENSG00000169564 PCBP1 cervical cancer 24848140
ENSG00000169564 PCBP1 gall bladder cancer 24889597
ENSG00000169564 PCBP1 tumor 25265318
ENSG00000169564 PCBP1 gastric cancer 25612617
ENSG00000169564 PCBP1 prostate cancer 25661993
ENSG00000169564 PCBP1 lung cancer 26261610
ENSG00000169564 PCBP1 AML 26293996
ENSG00000169564 PCBP1 cancer 26344801
ENSG00000169564 PCBP1 cancer 26368004
ENSG00000169564 PCBP1 tumor 26880484
ENSG00000169564 PCBP1 cancer 27067543
ENSG00000169564 PCBP1 cancer 27215579
ENSG00000169564 PCBP1 tumor 27629145
ENSG00000169564 PCBP1 tumor 27648147
ENSG00000169564 PCBP1 lung cancer 27683057
ENSG00000169564 PCBP1 Tumor 27746021
ENSG00000169564 PCBP1 Tumor 27912093
ENSG00000169564 PCBP1 tumor 28076324
ENSG00000169564 PCBP1 tumor 28250194
ENSG00000169564 PCBP1 thyroid cancer 28337299
ENSG00000169564 PCBP1 tumor 28560430
ENSG00000169564 PCBP1 cancers 28621149
ENSG00000169564 PCBP1 tumour 28825698
ENSG00000169564 PCBP1 Thyroid cancer 28963376
ENSG00000169564 PCBP1 gastric cancer 29138420
ENSG00000169564 PCBP1 breast cancer 29302577
ENSG00000169564 PCBP1 cancer 29396052
ENSG00000169564 PCBP1 cancer 29572294
ENSG00000169564 PCBP1 tumors 29622466
ENSG00000169564 PCBP1 Breast cancer 29867559
ENSG00000169564 PCBP1 Tumor 30078000
ENSG00000169564 PCBP1 tumor 30086790
ENSG00000169564 PCBP1 tumor 30132844
ENSG00000169564 PCBP1 gastric cancer 30246786
ENSG00000169564 PCBP1 cancer 30589983
ENSG00000169564 PCBP1 cancer 30626936
ENSG00000169564 PCBP1 tumor 30692635
ENSG00000169564 PCBP1 cancer 31138119
ENSG00000169564 PCBP1 cancer 31223278
ENSG00000169564 PCBP1 tumor 31223288
ENSG00000169564 PCBP1 tumor 31681852
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000169564 PCBP1 cecum adenocarcinoma missense_variant 3.2% (4/125) 1 entry
ENSG00000169564 PCBP1 colorectal adenocarcinoma missense_variant 2.636% (30/1138) 2 entries
ENSG00000169564 PCBP1 bladder carcinoma missense_variant 2.162% (12/555) 1 entry
ENSG00000169564 PCBP1 gastric adenocarcinoma missense_variant 0.7168% (4/558) 1 entry
ENSG00000169564 PCBP1 colon adenocarcinoma missense_variant 1.939% (14/722) 5 entries
ENSG00000169564 PCBP1 lung adenocarcinoma missense_variant 0.172% (2/1163) 1 entry
ENSG00000169564 PCBP1 clear cell renal carcinoma missense_variant 0.155% (2/1290) 1 entry
ENSG00000169564 PCBP1 rectal adenocarcinoma missense_variant 5.43% (12/221) 3 entries
ENSG00000169564 PCBP1 HER2 Positive Breast Carcinoma missense_variant 1.852% (2/108) 1 entry
ENSG00000169564 PCBP1 esophageal squamous cell carcinoma missense_variant 0.2963% (2/675) 2 entries
ENSG00000169564 PCBP1 esophageal adenocarcinoma sequence_alteration 0.4566% (2/438) 1 entry
ENSG00000169564 PCBP1 small cell lung carcinoma missense_variant 0.3145% (1/318) 1 entry
ENSG00000169564 PCBP1 colonic neoplasm missense_variant 6.667% (1/15) 1 entry
ENSG00000169564 PCBP1 alveolar rhabdomyosarcoma missense_variant 1.695% (1/59) 1 entry
ENSG00000169564 PCBP1 esophageal adenocarcinoma missense_variant 0.4566% (2/438) 1 entry
ENSG00000169564 PCBP1 large cell lung carcinoma missense_variant 5.556% (1/18) 1 entry
ENSG00000169564 PCBP1 acute lymphoblastic leukemia missense_variant 0.3115% (1/321) 1 entry
ENSG00000169564 PCBP1 melanoma stop_gained 0.9901% (1/101) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000169564 PCBP1 MESO 0.0012 low
ENSG00000169564 PCBP1 SARC 0.043 low
ENSG00000169564 PCBP1 STAD 0.027 low
ENSG00000169564 PCBP1 CHOL 0.038 low
ENSG00000169564 PCBP1 UVM 0.0079 high
ENSG00000169564 PCBP1 PAAD 0.017 high
ENSG00000169564 PCBP1 LGG 0.035 high
ENSG00000169564 PCBP1 HNSC 0.013 high
ENSG00000169564 PCBP1 READ 0.038 high
ENSG00000169564 PCBP1 KICH 0.03 low
ENSG00000169564 PCBP1 LUAD 0.013 high
ENSG00000169564 PCBP1 THYM 0.02 low
ENSG00000169564 PCBP1 BRCA 0.02 low
ENSG00000169564 PCBP1 COAD 0.0065 high
ENSG00000169564 PCBP1 ESCA 0.019 high
ENSG00000169564 PCBP1 DLBC 0.042 high
ENSG00000169564 PCBP1 LAML 0.0042 high
ENSG00000169564 PCBP1 SKCM 0.019 high
ENSG00000169564 PCBP1 CESC 0.037 high
ENSG00000169564 PCBP1 LIHC 0.04 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency