Ensembl ID ENSG00000169062 Gene ID 65110 Accession 20332
Gene Symbol UPF3A Alias UPF3;HUPF3A;RENT3A Full Name UPF3A regulator of nonsense mediated mRNA decay
Position 13 : 114281601 - 114305817 Length 24217 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]

ENSG00000169062 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000169062 UPF3A 0.70 3.20e-11 COAD
ENSG00000169062 UPF3A 0.37 9.35e-12 PRAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000169062 UPF3A cancer 25230976
ENSG00000169062 UPF3A tumor 29181411
ENSG00000169062 UPF3A tumor 30228267
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000169062 UPF3A SARC 0.00093 high
ENSG00000169062 UPF3A STAD 0.02 low
ENSG00000169062 UPF3A CHOL 0.039 high
ENSG00000169062 UPF3A UCEC 0.027 high
ENSG00000169062 UPF3A THCA 0.043 low
ENSG00000169062 UPF3A ACC 0.03 high
ENSG00000169062 UPF3A LGG 0.00074 low
ENSG00000169062 UPF3A HNSC 0.014 low
ENSG00000169062 UPF3A READ 0.038 low
ENSG00000169062 UPF3A KIRP 0.008 low
ENSG00000169062 UPF3A THYM 0.031 low
ENSG00000169062 UPF3A BRCA 0.012 low
ENSG00000169062 UPF3A UCS 0.023 low
ENSG00000169062 UPF3A KIRC 0.0021 high
ENSG00000169062 UPF3A PRAD 0.013 high
ENSG00000169062 UPF3A TGCT 0.0026 low
ENSG00000169062 UPF3A BLCA 0.0012 low
ENSG00000169062 UPF3A LAML 0.0093 high
ENSG00000169062 UPF3A GBM 0.017 low
ENSG00000169062 UPF3A SKCM 0.044 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency