Ensembl ID
ENSG00000168827
Gene ID
85476
Accession
13780
Gene Symbol
GFM1
Alias
EFG;GFM;EFG1;EFGM;EGF1;hEFG1;COXPD1;mtEF-G1
Full Name
G elongation factor mitochondrial 1
Position
3 : 158644527 - 158695581
Length
51055 bases
Strand
Plus strand
Status
Confidence
Main interacting RNAs mRNA RBP type
Canonical_RBPs
Summary
Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. [provided by RefSeq, Jul 2008]
ENSG00000168827 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000168827
GFM1
-0.9
3.18e-37
KIRC
ENSG00000168827
GFM1
0.95
6.67e-35
LUSC
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000168827
GFM1
breast cancer
10597254
ENSG00000168827
GFM1
gastric cancer
12008203
ENSG00000168827
GFM1
skin tumors
18042248
ENSG00000168827
GFM1
ovarian cancer
21916103
ENSG00000168827
GFM1
tumor
23239936
ENSG00000168827
GFM1
tumours
25867268
ENSG00000168827
GFM1
AML
27486981
ENSG00000168827
GFM1
tumors
29582677
ENSG00000168827
GFM1
cancer
30416686
ENSG00000168827
GFM1
tumor
3316253
ENSG00000168827
GFM1
tumour
9639091
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000168827
GFM1
MESO
0.0033
high
show
ENSG00000168827
GFM1
SARC
0.05
high
show
ENSG00000168827
GFM1
UVM
0.0019
low
show
ENSG00000168827
GFM1
PAAD
0.0013
high
show
ENSG00000168827
GFM1
UCEC
0.0026
high
show
ENSG00000168827
GFM1
THCA
0.027
high
show
ENSG00000168827
GFM1
LUSC
0.0089
low
show
ENSG00000168827
GFM1
READ
0.025
low
show
ENSG00000168827
GFM1
LUAD
0.011
high
show
ENSG00000168827
GFM1
BRCA
0.035
high
show
ENSG00000168827
GFM1
COAD
0.017
low
show
ENSG00000168827
GFM1
PRAD
0.0014
low
show
ENSG00000168827
GFM1
LIHC
0.018
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000168827
GFM1
LUSC
Amp
67.634205
1.065479
1.034579
0.852295
ENSG00000168827
GFM1
LUAD
Amp
0.647562
0.115099
0.429236
0.263566
ENSG00000168827
GFM1
CESC
Amp
17.070570
0.498068
1.011963
0.725424
ENSG00000168827
GFM1
ESCA
Amp
10.689576
0.690028
0.877088
0.635870
ENSG00000168827
GFM1
HNSC
Amp
26.693950
0.472425
0.741379
0.685824
ENSG00000168827
GFM1
PCPG
Del
0.899050
0.062820
0.631584
0.580247
ENSG00000168827
GFM1
TGCT
Amp
0.882927
0.126047
0.428502
0.306667
ENSG00000168827
GFM1
BRCA
Amp
1.293426
0.157567
0.524101
0.278704
ENSG00000168827
GFM1
STAD
Amp
1.844286
0.165796
0.486467
0.310658
ENSG00000168827
GFM1
PRAD
Amp
1.055801
0.051096
0.408517
0.146341
ENSG00000168827
GFM1
UCEC
Amp
5.469388
0.189376
0.665479
0.244898
ENSG00000168827
GFM1
KIRC
Amp
0.857461
0.036840
0.385864
0.153409
ENSG00000168827
GFM1
OV
Amp
22.837664
0.733369
0.858830
0.718480
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