Ensembl ID ENSG00000168517 Gene ID 124790 Accession 28591
Gene Symbol HEXIM2 Alias L3 Full Name HEXIM P-TEFb complex subunit 2
Position 17 : 45160700 - 45170040 Length 9341 bases Strand Plus strand
Status Confidence Main interacting RNAsncRNARBP type Canonical_RBPs
Summary This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

ENSG00000168517 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000168517 HEXIM2 0.51 6.16e-11 BRCA
ENSG00000168517 HEXIM2 0.66 4.68e-13 LUSC
ENSG00000168517 HEXIM2 0.57 1.99e-12 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000168517 HEXIM2 SARC 0.029 low
ENSG00000168517 HEXIM2 STAD 0.0015 low
ENSG00000168517 HEXIM2 UVM 0.018 high
ENSG00000168517 HEXIM2 PAAD 0.0033 low
ENSG00000168517 HEXIM2 UCEC 0.00068 low
ENSG00000168517 HEXIM2 THCA 0.044 low
ENSG00000168517 HEXIM2 ACC 0.048 high
ENSG00000168517 HEXIM2 LUSC 0.045 low
ENSG00000168517 HEXIM2 HNSC 0.0086 low
ENSG00000168517 HEXIM2 READ 0.0038 low
ENSG00000168517 HEXIM2 KIRP 0.00023 low
ENSG00000168517 HEXIM2 KICH 0.0049 high
ENSG00000168517 HEXIM2 LUAD 0.031 low
ENSG00000168517 HEXIM2 PCPG 0.012 high
ENSG00000168517 HEXIM2 THYM 0.029 low
ENSG00000168517 HEXIM2 BRCA 0.013 low
ENSG00000168517 HEXIM2 COAD 0.0054 high
ENSG00000168517 HEXIM2 ESCA 0.046 low
ENSG00000168517 HEXIM2 OV 0.00082 low
ENSG00000168517 HEXIM2 BLCA 0.018 low
ENSG00000168517 HEXIM2 LAML 0.012 high
ENSG00000168517 HEXIM2 SKCM 0.00075 low
ENSG00000168517 HEXIM2 CESC 0.016 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000168517 HEXIM2 PCPG Del 0.836580 0.061484 0.598642 0.135802
ENSG00000168517 HEXIM2 BRCA Del 6.868592 0.101649 0.434965 0.335185
ENSG00000168517 HEXIM2 PRAD Del 4.353462 0.110025 0.449982 0.140244
ENSG00000168517 HEXIM2 UCEC Del 3.557653 0.077332 0.570325 0.198516