Ensembl ID ENSG00000168496 Gene ID 2237 Accession 3650
Gene Symbol FEN1 Alias MF1;RAD2;FEN-1 Full Name flap structure-specific endonuclease 1
Position 11 : 61792911 - 61797238 Length 4328 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]

ENSG00000168496 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000168496 0.50 5.77e-14 KIRC
ENSG00000168496 1.24 1.34e-35 HNSC
ENSG00000168496 1.47 9.42e-13 BLCA
ENSG00000168496 1.62 5.92e-93 BRCA
ENSG00000168496 0.97 1.11e-23 COAD
ENSG00000168496 0.95 7.78e-15 KICH
ENSG00000168496 2.25 2.07e-131 LUSC
ENSG00000168496 0.49 9.27e-11 PRAD
ENSG00000168496 1.61 6.36e-42 LIHC
ENSG00000168496 1.07 7.18e-17 STAD
ENSG00000168496 2.20 2.34e-62 UCEC
ENSG00000168496 3.07 1.31e-23 CESC
ENSG00000168496 1.57 2.35e-47 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000168496 tumour 12878006
ENSG00000168496 lung cancer 14562054
ENSG00000168496 tumor 16170025
ENSG00000168496 prostate cancer 16879693
ENSG00000168496 tumor 1688517
ENSG00000168496 cancer 17589521
ENSG00000168496 breast cancer 18237428
ENSG00000168496 cancer 18443037
ENSG00000168496 breast cancer 18669164
ENSG00000168496 cancer 18702299
ENSG00000168496 cancers 19010819
ENSG00000168496 cancer 19068479
ENSG00000168496 tumor 19137021
ENSG00000168496 colorectal cancer 19218431
ENSG00000168496 breast cancer 19522845
ENSG00000168496 cancer 19525235
ENSG00000168496 brain tumors 19596913
ENSG00000168496 lung cancer 19618370
ENSG00000168496 cancer 20929870
ENSG00000168496 cancer 20972458
ENSG00000168496 cancers 21062821
ENSG00000168496 cancer 21383776
ENSG00000168496 cancer 21612397
ENSG00000168496 ovarian tumor 2182406
ENSG00000168496 ovarian cancer 2197240
ENSG00000168496 esophageal cancer 22072618
ENSG00000168496 lung cancer 22155171
ENSG00000168496 cancers 22569363
ENSG00000168496 cancer 22788768
ENSG00000168496 gastric cancer 22894650
ENSG00000168496 lung cancer 23184144
ENSG00000168496 cancer 23382697
ENSG00000168496 cancers 23427045
ENSG00000168496 cancer 24202319
ENSG00000168496 cancer 24349332
ENSG00000168496 breast cancer 24440783
ENSG00000168496 breast cancer 24486718
ENSG00000168496 gastric cancer 24590400
ENSG00000168496 cancers 24608430
ENSG00000168496 cancer 24701133
ENSG00000168496 cancer 24836286
ENSG00000168496 ovarian cancer 24880630
ENSG00000168496 breast cancer 25111287
ENSG00000168496 cancer 25154853
ENSG00000168496 tumors 25425972
ENSG00000168496 breast cancer 25665066
ENSG00000168496 breast cancer 25885449
ENSG00000168496 cancer 25921062
ENSG00000168496 cancer 25922071
ENSG00000168496 tumour 26267318
ENSG00000168496 lung cancer 26431531
ENSG00000168496 breast cancers 26459098
ENSG00000168496 tumor 26545110
ENSG00000168496 gallbladder cancer 26668074
ENSG00000168496 colorectal cancer 26708601
ENSG00000168496 gastric cancer 26718738
ENSG00000168496 cancer 26807246
ENSG00000168496 lung cancer 26811808
ENSG00000168496 cancer 27020684
ENSG00000168496 breast cancer 27088617
ENSG00000168496 cancer 27270424
ENSG00000168496 primary cancer 27391345
ENSG00000168496 tumor 27467592
ENSG00000168496 colon cancer 27526030
ENSG00000168496 Cancer 27655641
ENSG00000168496 breast cancer 27699013
ENSG00000168496 breast cancer 27801669
ENSG00000168496 cancer 27832451
ENSG00000168496 Breast Cancer 27852524
ENSG00000168496 breast cancer 28034453
ENSG00000168496 cancer 28187440
ENSG00000168496 breast cancers 28254786
ENSG00000168496 esophageal cancer 28319330
ENSG00000168496 tumor 28371273
ENSG00000168496 cancer 28628639
ENSG00000168496 cancers 28653660
ENSG00000168496 cancer 28685785
ENSG00000168496 breast cancer 28724427
ENSG00000168496 non-small-cell lung cancer 28861953
ENSG00000168496 tumour 28903334
ENSG00000168496 breast cancer 28912877
ENSG00000168496 cancer 28918054
ENSG00000168496 tumor 29033691
ENSG00000168496 Non-Small-Cell Lung Cancer 29037854
ENSG00000168496 cancer 29109095
ENSG00000168496 tumor 29348864
ENSG00000168496 cervical cancer 29358095
ENSG00000168496 breast cancer 29541412
ENSG00000168496 cancer 29718417
ENSG00000168496 tumors 29735403
ENSG00000168496 cancer 29741650
ENSG00000168496 colorectal cancer 29869816
ENSG00000168496 Wilms tumor 29937070
ENSG00000168496 cancers 30011902
ENSG00000168496 cancer 30184152
ENSG00000168496 lung cancer 30260965
ENSG00000168496 cancer 30295841
ENSG00000168496 Cancer 30336066
ENSG00000168496 tumors 30526646
ENSG00000168496 cancers 30558228
ENSG00000168496 Colon Cancer 30694659
ENSG00000168496 breast cancer 30712236
ENSG00000168496 cancer 30937972
ENSG00000168496 breast cancer 31266372
ENSG00000168496 Cancer 31272350
ENSG00000168496 cancers 31402791
ENSG00000168496 Cancer 31467180
ENSG00000168496 breast cancer 31471584
ENSG00000168496 liver cancer 31534853
ENSG00000168496 tumours 31572192
ENSG00000168496 cervical cancer 31670906
ENSG00000168496 breast cancer 31777591
ENSG00000168496 cancer 31937519
ENSG00000168496 tumor 8144677
ENSG00000168496 cancers 9778254
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000168496 colorectal adenocarcinoma missense_variant 0.7909% (9/1138) 1 entry
ENSG00000168496 lung adenocarcinoma missense_variant 0.3279% (4/1220) 2 entries
ENSG00000168496 colon adenocarcinoma missense_variant 0.554% (4/722) 2 entries
ENSG00000168496 colorectal adenocarcinoma stop_gained 0.7909% (9/1138) 1 entry
ENSG00000168496 esophageal squamous cell carcinoma missense_variant 0.2963% (2/675) 2 entries
ENSG00000168496 ovarian serous adenocarcinoma missense_variant 0.2972% (2/673) 1 entry
ENSG00000168496 alveolar rhabdomyosarcoma missense_variant 1.695% (1/59) 1 entry
ENSG00000168496 hepatocellular carcinoma missense_variant 0.2225% (2/899) 1 entry
ENSG00000168496 oral squamous cell carcinoma missense_variant 0.4878% (1/205) 1 entry
ENSG00000168496 diffuse large B-cell lymphoma missense_variant 0.3289% (1/304) 1 entry
ENSG00000168496 squamous cell lung carcinoma missense_variant 0.2424% (2/825) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000168496 STAD 0.0011 low
ENSG00000168496 UVM 0.00092 high
ENSG00000168496 PAAD 0.0034 high
ENSG00000168496 THCA 0.0041 low
ENSG00000168496 LGG 0.00058 high
ENSG00000168496 HNSC 0.023 low
ENSG00000168496 READ 0.02 low
ENSG00000168496 LUAD 0.00078 high
ENSG00000168496 THYM 0.013 low
ENSG00000168496 COAD 0.0054 high
ENSG00000168496 OV 0.0011 low
ENSG00000168496 DLBC 0.028 low
ENSG00000168496 KIRC 0.0021 high
ENSG00000168496 PRAD 0.013 high
ENSG00000168496 BLCA 0.026 high
ENSG00000168496 LAML 0.0012 high
ENSG00000168496 GBM 0.03 high
ENSG00000168496 SKCM 0.033 high
ENSG00000168496 CESC 0.026 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000168496 TGCT Del 1.022825 0.063515 0.400881 0.753333